ID KBTB3_MOUSE Reviewed; 607 AA.
AC Q8BHI4; Q8BNJ8;
DT 19-SEP-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 24-JAN-2024, entry version 153.
DE RecName: Full=Kelch repeat and BTB domain-containing protein 3 {ECO:0000305};
DE AltName: Full=BTB and kelch domain-containing protein 3;
GN Name=Kbtbd3 {ECO:0000312|MGI:MGI:1916399}; Synonyms=Bklhd3;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Diencephalon, and Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
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DR EMBL; AK034334; BAC28678.1; -; mRNA.
DR EMBL; AK078744; BAC37374.1; -; mRNA.
DR EMBL; AK083497; BAC38935.1; -; mRNA.
DR EMBL; BC027392; AAH27392.1; -; mRNA.
DR CCDS; CCDS22795.1; -.
DR RefSeq; NP_001158046.1; NM_001164574.1.
DR RefSeq; NP_081238.2; NM_026962.3.
DR RefSeq; XP_011240669.1; XM_011242367.1.
DR RefSeq; XP_011240670.1; XM_011242368.1.
DR AlphaFoldDB; Q8BHI4; -.
DR SMR; Q8BHI4; -.
DR STRING; 10090.ENSMUSP00000148445; -.
DR PhosphoSitePlus; Q8BHI4; -.
DR PaxDb; 10090-ENSMUSP00000050183; -.
DR ProteomicsDB; 263576; -.
DR Antibodypedia; 54357; 112 antibodies from 16 providers.
DR DNASU; 69149; -.
DR Ensembl; ENSMUST00000049648.9; ENSMUSP00000050183.8; ENSMUSG00000025893.9.
DR Ensembl; ENSMUST00000212221.2; ENSMUSP00000148445.2; ENSMUSG00000025893.9.
DR GeneID; 69149; -.
DR KEGG; mmu:69149; -.
DR UCSC; uc009obj.2; mouse.
DR AGR; MGI:1916399; -.
DR CTD; 143879; -.
DR MGI; MGI:1916399; Kbtbd3.
DR VEuPathDB; HostDB:ENSMUSG00000025893; -.
DR eggNOG; KOG4441; Eukaryota.
DR GeneTree; ENSGT00940000158415; -.
DR HOGENOM; CLU_004253_14_6_1; -.
DR InParanoid; Q8BHI4; -.
DR OMA; KGKCCRK; -.
DR OrthoDB; 5472491at2759; -.
DR PhylomeDB; Q8BHI4; -.
DR TreeFam; TF329218; -.
DR BioGRID-ORCS; 69149; 1 hit in 76 CRISPR screens.
DR ChiTaRS; Kbtbd3; mouse.
DR PRO; PR:Q8BHI4; -.
DR Proteomes; UP000000589; Chromosome 9.
DR RNAct; Q8BHI4; Protein.
DR Bgee; ENSMUSG00000025893; Expressed in interventricular septum and 124 other cell types or tissues.
DR Genevisible; Q8BHI4; MM.
DR CDD; cd18480; BACK_KBTBD3; 1.
DR CDD; cd18271; BTB_POZ_KBTBD3_BKLHD3; 1.
DR Gene3D; 1.25.40.420; -; 1.
DR Gene3D; 2.120.10.80; Kelch-type beta propeller; 2.
DR InterPro; IPR011705; BACK.
DR InterPro; IPR017096; BTB-kelch_protein.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR030589; BTB/POZ_KBTBD3.
DR InterPro; IPR047062; KBTBD3_BACK.
DR InterPro; IPR015915; Kelch-typ_b-propeller.
DR InterPro; IPR006652; Kelch_1.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR PANTHER; PTHR24412; KELCH PROTEIN; 1.
DR PANTHER; PTHR24412:SF418; KELCH REPEAT AND BTB DOMAIN-CONTAINING PROTEIN 3; 1.
DR Pfam; PF07707; BACK; 1.
DR Pfam; PF00651; BTB; 1.
DR Pfam; PF01344; Kelch_1; 2.
DR PIRSF; PIRSF037037; Kelch-like_protein_gigaxonin; 1.
DR SMART; SM00875; BACK; 1.
DR SMART; SM00225; BTB; 1.
DR SMART; SM00612; Kelch; 3.
DR SUPFAM; SSF117281; Kelch motif; 1.
DR SUPFAM; SSF54695; POZ domain; 1.
DR PROSITE; PS50097; BTB; 1.
PE 2: Evidence at transcript level;
KW Kelch repeat; Reference proteome; Repeat.
FT CHAIN 1..607
FT /note="Kelch repeat and BTB domain-containing protein 3"
FT /id="PRO_0000119079"
FT DOMAIN 48..115
FT /note="BTB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT DOMAIN 150..250
FT /note="BACK"
FT /evidence="ECO:0000255"
FT REPEAT 291..337
FT /note="Kelch 1"
FT /evidence="ECO:0000255"
FT REPEAT 339..390
FT /note="Kelch 2"
FT /evidence="ECO:0000255"
FT REPEAT 400..450
FT /note="Kelch 3"
FT /evidence="ECO:0000255"
FT REPEAT 452..502
FT /note="Kelch 4"
FT /evidence="ECO:0000255"
FT REPEAT 548..595
FT /note="Kelch 5"
FT /evidence="ECO:0000255"
FT CONFLICT 440
FT /note="I -> M (in Ref. 1; BAC38935)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 607 AA; 69551 MW; 1AE2DAE6875244CD CRC64;
MDNSYNLNEQ SSWNGISSEK KKNYLASEDH GQKILSVLQS FREQNVFYDF KIIMKEEIIP
CHRCVLAACS DFFRAMFEVN MKERDDGSVT ITNLSSKAVK AFLDYAYTGK TRITDDNVEM
FFQLSSFLQV SFLSKACSDF LIKSISLVNC LHLLSLSDSY GSAQLFSHTL YFVQHHFHLL
YKSSDFLEMN FGVLQKCLES DELNVPEEEM VLKAVLTWIK YNLESRQKHL PHLITKVRLH
QLSEDTLQDY LLNEEYLLKS TNCFDIIVDA IKCVQGSSGL FPDARPSTTE KYIFIHKTEE
NGENQYTFCY NIKTDSWKIL PQSHLIDLPG SSLSSYGEKI FLTGGCKGKC CRRIRLHIAQ
SYHDATDQTW CYCPAKNEFF CVSAMKTPRT MHTSVMALNR LFVIGGKTRG SQDIKSLLDV
ESYNPLSREW TSVSPLPRGI YYPEASACQN IIYVLGSEVE IADAFNPSLD CFFKYNATTD
QWSELVAEFG QFFHATLIKA VPVNCTLYIC DLSTYKVYSF CPDTCVWKGE GSFECAGFNA
GAIGIEDKIY ILGGDYAPDE ITDEVQVYHS SRSEWEEVSP MPRALTEFYC QVIQFNKYRD
PWYSNHF
//
