ID   KCD19_BOVIN             Reviewed;         927 AA.
AC   A7YWH3;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   23-OCT-2007, sequence version 1.
DT   27-MAR-2024, entry version 75.
DE   RecName: Full=BTB/POZ domain-containing protein KCTD19;
GN   Name=KCTD19;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Basal ganglia;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcription regulator which is essential for male fertility
CC       and for the completion of meiotic prophase in spermatocytes. Regulates
CC       progression of the pachytene stage of meiotic prophase and promotes the
CC       transcriptional activation activity ZNF541. Required for the
CC       organization of chromosomes during metaphase I.
CC       {ECO:0000250|UniProtKB:Q562E2}.
CC   -!- SUBUNIT: Identified in a complex with ZNF541, HDAC1 and HSPA2.
CC       Identified in a complex with ZNF541 and HDAC1. Identified in a complex
CC       with HDAC1, HDAC2, DNTTIP1 and ZNF541. {ECO:0000250|UniProtKB:Q562E2}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q562E2}.
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DR   EMBL; BC134572; AAI34573.1; -; mRNA.
DR   RefSeq; NP_001098862.1; NM_001105392.1.
DR   AlphaFoldDB; A7YWH3; -.
DR   SMR; A7YWH3; -.
DR   STRING; 9913.ENSBTAP00000043298; -.
DR   PaxDb; 9913-ENSBTAP00000043298; -.
DR   GeneID; 523858; -.
DR   KEGG; bta:523858; -.
DR   CTD; 146212; -.
DR   eggNOG; KOG0342; Eukaryota.
DR   eggNOG; KOG2723; Eukaryota.
DR   HOGENOM; CLU_014244_0_0_1; -.
DR   InParanoid; A7YWH3; -.
DR   OrthoDB; 5310835at2759; -.
DR   TreeFam; TF315332; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0007140; P:male meiotic nuclear division; ISS:UniProtKB.
DR   GO; GO:0051260; P:protein homooligomerization; IEA:InterPro.
DR   GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
DR   CDD; cd18373; BTB1_POZ_KCTD19; 1.
DR   CDD; cd18374; BTB2_POZ_KCTD19; 1.
DR   InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR   InterPro; IPR003131; T1-type_BTB.
DR   PANTHER; PTHR14499:SF10; BTB_POZ DOMAIN-CONTAINING PROTEIN KCTD6; 1.
DR   PANTHER; PTHR14499; POTASSIUM CHANNEL TETRAMERIZATION DOMAIN-CONTAINING; 1.
DR   Pfam; PF02214; BTB_2; 1.
DR   SUPFAM; SSF54695; POZ domain; 3.
PE   2: Evidence at transcript level;
KW   Activator; Differentiation; Meiosis; Nucleus; Phosphoprotein;
KW   Reference proteome; Repeat; Spermatogenesis; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..927
FT                   /note="BTB/POZ domain-containing protein KCTD19"
FT                   /id="PRO_0000313586"
FT   DOMAIN          18..72
FT                   /note="BTB 1"
FT   DOMAIN          399..486
FT                   /note="BTB 2"
FT   REGION          603..631
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          662..718
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        613..627
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        662..691
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         270
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q562E2"
SQ   SEQUENCE   927 AA;  105078 MW;  208023C499FFEA0A CRC64;
     MEEPGMPHES AEDLFHFNVG GWHFSVPRSK LAQFPDSLLW KEASALTSSE NQRLFIDRDG
     STFRHVHYYL YTSKLSFSSC AELNLLYEQA LGLQLMPLLQ TLDNLKEGKH HLRVRPADIP
     VAERASLNYW RTWKCISKPS EFPIKSPAFT GLHDKAPLGL MDTPLLDTEE EVHYCFLPLD
     LVAKHPSLVT EDNLLWLAET MALIECECSE FRFIVNFLRS QKILLPDNFS NIDVLEAEVE
     ILEIPELSEA VRLYRMNMGG CSRTSCPPPS PGKGGRSAGL ESVKPLYMMA LGLLVKYPDS
     ALGQLRIEST LDGSRLYITG NGVLFQHVKN WLGTCRLPLT ETVSEVYELC AFLDKRDITY
     EPMKVALKTH LEPRTLAPMD VLNEEWTAEI TVYSSQQIIK VYVGSHWYAT TLQTLLKYPE
     LLSNPQRVYW ITYGQTLLIY GDGQMFRHIL NFLRLGKLFL PTEFKEWPLL CQEVEEYHIP
     SLSEALVQCE AYKSWIQEKE SENEEAFPIR RLHVVTEGPG SLVEFSRDTK ETMACVPMEF
     QDCNDRTMWN KAKGTLARSS QIEEAEQYSQ TIQMSLCRGA KRAGNPSTYS HCPGLCANPR
     HWGGHPESPP KKKCTTVNLT QKPETKDPPV TPMQKLISLV REWDMVNCKQ WEFQSLPAPR
     NSSLEEATLQ HSSGSEAVSQ PSTSASWKGH STASEKDPGP QAGAGAGTKD KGPEPNFNPY
     FPMKRAVALK DWGKQRSKER ENPAFELTLP EASEGDNTGV ILKVTHPPVV GSDGSCMFFE
     DSIIYTTHMD HLRRTPPPAS PQPREVTFLS FSLSWEEMFY AQKCHCFLTD IILDSIRQND
     PKAITAKVVS LVNQLWTLHI SPKQFVVDLL AITGFKDDRH TQERLYSWVE LTLPFARKYG
     RCVDLLIQRG LSKSVSYSVL SKYLQDG
//