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Database: UniProt
Entry: KCJ14_HUMAN
LinkDB: KCJ14_HUMAN
Original site: KCJ14_HUMAN 
ID   KCJ14_HUMAN             Reviewed;         436 AA.
AC   Q9UNX9;
DT   11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   16-OCT-2019, entry version 142.
DE   RecName: Full=ATP-sensitive inward rectifier potassium channel 14;
DE   AltName: Full=Inward rectifier K(+) channel Kir2.4;
DE            Short=IRK-4;
DE   AltName: Full=Potassium channel, inwardly rectifying subfamily J member 14;
GN   Name=KCNJ14; Synonyms=IRK4;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION, AND TISSUE SPECIFICITY.
RX   PubMed=10942728; DOI=10.1152/ajpcell.2000.279.3.c771;
RA   Hughes B.A., Kumar G., Yuan Y., Swaminathan A., Yan D., Sharma A.,
RA   Plumley L., Yang-Feng T.L., Swaroop A.;
RT   "Cloning and functional expression of human retinal Kir2.4, a pH-
RT   sensitive inwardly rectifying K+ channel.";
RL   Am. J. Physiol. 279:C771-C784(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=10723734; DOI=10.1007/s003350010047;
RA   Toepert C., Doring F., Derst C., Daut J., Grzeschik K.H., Karschin A.;
RT   "Cloning, structure and assignment to chromosome 19q13 of the human
RT   Kir2.4 inwardly rectifying potassium channel gene (KCNJ14).";
RL   Mamm. Genome 11:247-249(2000).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Uterus;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Inward rectifier potassium channels are characterized by
CC       a greater tendency to allow potassium to flow into the cell rather
CC       than out of it. Their voltage dependence is regulated by the
CC       concentration of extracellular potassium; as external potassium is
CC       raised, the voltage range of the channel opening shifts to more
CC       positive voltages. The inward rectification is mainly due to the
CC       blockage of outward current by internal magnesium. KCNJ14 gives
CC       rise to low-conductance channels with a low affinity to the
CC       channel blockers Barium and Cesium (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC   -!- TISSUE SPECIFICITY: Expressed preferentially in retina.
CC       {ECO:0000269|PubMed:10942728}.
CC   -!- SIMILARITY: Belongs to the inward rectifier-type potassium channel
CC       (TC 1.A.2.1) family. KCNJ14 subfamily. {ECO:0000305}.
DR   EMBL; AF081466; AAD51376.1; -; mRNA.
DR   EMBL; AF181988; AAF97619.1; -; Genomic_DNA.
DR   EMBL; BC035918; AAH35918.1; -; mRNA.
DR   CCDS; CCDS12721.1; -.
DR   RefSeq; NP_037480.1; NM_013348.3.
DR   SMR; Q9UNX9; -.
DR   STRING; 9606.ENSP00000375756; -.
DR   DrugBank; DB11148; Butamben.
DR   DrugBank; DB01392; Yohimbine.
DR   GuidetoPHARMACOLOGY; 433; -.
DR   BioMuta; KCNJ14; -.
DR   DMDM; 54036159; -.
DR   MassIVE; Q9UNX9; -.
DR   PaxDb; Q9UNX9; -.
DR   PeptideAtlas; Q9UNX9; -.
DR   PRIDE; Q9UNX9; -.
DR   ProteomicsDB; 85341; -.
DR   TopDownProteomics; Q9UNX9; -.
DR   Ensembl; ENST00000342291; ENSP00000341479; ENSG00000182324.
DR   Ensembl; ENST00000391884; ENSP00000375756; ENSG00000182324.
DR   GeneID; 3770; -.
DR   KEGG; hsa:3770; -.
DR   UCSC; uc002pje.3; human.
DR   CTD; 3770; -.
DR   GeneCards; KCNJ14; -.
DR   HGNC; HGNC:6260; KCNJ14.
DR   HPA; HPA071765; -.
DR   MIM; 603953; gene.
DR   neXtProt; NX_Q9UNX9; -.
DR   OpenTargets; ENSG00000182324; -.
DR   PharmGKB; PA30045; -.
DR   eggNOG; KOG3827; Eukaryota.
DR   eggNOG; ENOG410XQ62; LUCA.
DR   GeneTree; ENSGT00960000186595; -.
DR   HOGENOM; HOG000237325; -.
DR   InParanoid; Q9UNX9; -.
DR   KO; K05007; -.
DR   OMA; QHGSQYE; -.
DR   OrthoDB; 956263at2759; -.
DR   PhylomeDB; Q9UNX9; -.
DR   TreeFam; TF313676; -.
DR   Reactome; R-HSA-1296053; Classical Kir channels.
DR   Reactome; R-HSA-5576886; Phase 4 - resting membrane potential.
DR   GeneWiki; KCNJ14; -.
DR   GenomeRNAi; 3770; -.
DR   Pharos; Q9UNX9; -.
DR   PRO; PR:Q9UNX9; -.
DR   Proteomes; UP000005640; Chromosome 19.
DR   Bgee; ENSG00000182324; Expressed in 81 organ(s), highest expression level in dorsolateral prefrontal cortex.
DR   Genevisible; Q9UNX9; HS.
DR   GO; GO:0030425; C:dendrite; IEA:Ensembl.
DR   GO; GO:0043025; C:neuronal cell body; IEA:Ensembl.
DR   GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR   GO; GO:0008076; C:voltage-gated potassium channel complex; TAS:ProtInc.
DR   GO; GO:0005242; F:inward rectifier potassium channel activity; IBA:GO_Central.
DR   GO; GO:0061337; P:cardiac conduction; TAS:Reactome.
DR   GO; GO:1990573; P:potassium ion import across plasma membrane; IBA:GO_Central.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.1400; -; 1.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR041647; IRK_C.
DR   InterPro; IPR016449; K_chnl_inward-rec_Kir.
DR   InterPro; IPR013518; K_chnl_inward-rec_Kir_cyto.
DR   InterPro; IPR040445; Kir_TM.
DR   PANTHER; PTHR11767; PTHR11767; 1.
DR   Pfam; PF01007; IRK; 1.
DR   Pfam; PF17655; IRK_C; 1.
DR   PIRSF; PIRSF005465; GIRK_kir; 1.
DR   PRINTS; PR01320; KIRCHANNEL.
DR   SUPFAM; SSF81296; SSF81296; 1.
PE   1: Evidence at protein level;
KW   Complete proteome; Ion channel; Ion transport; Membrane; Polymorphism;
KW   Potassium; Potassium transport; Reference proteome; S-nitrosylation;
KW   Transmembrane; Transmembrane helix; Transport; Voltage-gated channel.
FT   CHAIN         1    436       ATP-sensitive inward rectifier potassium
FT                                channel 14.
FT                                /FTId=PRO_0000154968.
FT   TOPO_DOM      1     86       Cytoplasmic. {ECO:0000250}.
FT   TRANSMEM     87    111       Helical; Name=M1. {ECO:0000250}.
FT   TOPO_DOM    112    133       Extracellular. {ECO:0000250}.
FT   INTRAMEM    134    145       Helical; Pore-forming; Name=H5.
FT                                {ECO:0000250}.
FT   INTRAMEM    146    152       Pore-forming. {ECO:0000250}.
FT   TOPO_DOM    153    161       Extracellular. {ECO:0000250}.
FT   TRANSMEM    162    183       Helical; Name=M2. {ECO:0000250}.
FT   TOPO_DOM    184    436       Cytoplasmic. {ECO:0000250}.
FT   MOTIF       147    152       Selectivity filter. {ECO:0000250}.
FT   MOD_RES      81     81       S-nitrosocysteine.
FT                                {ECO:0000250|UniProtKB:P63252}.
FT   VARIANT     289    289       R -> C (in dbSNP:rs3745725).
FT                                /FTId=VAR_034019.
SQ   SEQUENCE   436 AA;  47846 MW;  9442E664007D1B7C CRC64;
     MGLARALRRL SGALDSGDSR AGDEEEAGPG LCRNGWAPAP VQSPVGRRRG RFVKKDGHCN
     VRFVNLGGQG ARYLSDLFTT CVDVRWRWMC LLFSCSFLAS WLLFGLAFWL IASLHGDLAA
     PPPPAPCFSH VASFLAAFLF ALETQTSIGY GVRSVTEECP AAVAAVVLQC IAGCVLDAFV
     VGAVMAKMAK PKKRNETLVF SENAVVALRD HRLCLMWRVG NLRRSHLVEA HVRAQLLQPR
     VTPEGEYIPL DHQDVDVGFD GGTDRIFLVS PITIVHEIDS ASPLYELGRA ELARADFELV
     VILEGMVEAT AMTTQCRSSY LPGELLWGHR FEPVLFQRGS QYEVDYRHFH RTYEVPGTPV
     CSAKELDERA EQASHSLKSS FPGSLTAFCY ENELALSCCQ EEDEDDETEE GNGVETEDGA
     ASPRVLTPTL ALTLPP
//
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