ID KCTD5_RAT Reviewed; 234 AA.
AC B5DEL1;
DT 15-DEC-2009, integrated into UniProtKB/Swiss-Prot.
DT 14-OCT-2008, sequence version 1.
DT 27-MAR-2024, entry version 85.
DE RecName: Full=BTB/POZ domain-containing protein KCTD5;
GN Name=Kctd5;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway;
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Its interaction with CUL3 suggests that it may act as a
CC substrate adapter in some E3 ligase complex (By similarity). Does not
CC affect the function of Kv channel Kv2.1/KCNB1, Kv1.2/KCNA2, Kv4.2/KCND2
CC and Kv3.4/KCNC4 (By similarity). {ECO:0000250|UniProtKB:Q9NXV2}.
CC -!- SUBUNIT: Homopentamer (By similarity). Interacts (via C-terminus) with
CC GRASP55/GORASP2 (By similarity). Interacts with CUL3 and with
CC ubiquitinated proteins (By similarity). Interacts with CRY1 (By
CC similarity). {ECO:0000250|UniProtKB:Q8VC57,
CC ECO:0000250|UniProtKB:Q9NXV2}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000250|UniProtKB:Q9NXV2}. Cytoplasm
CC {ECO:0000250|UniProtKB:Q9NXV2}. Nucleus {ECO:0000250|UniProtKB:Q9NXV2}.
CC Note=Predominantly cytoplasmic, translocated to the nucleus upon
CC interaction with Rep proteins. {ECO:0000250|UniProtKB:Q9NXV2}.
CC -!- DOMAIN: The BTB (POZ) domain is atypical and mediates the formation of
CC a homopentamer instead of a homotetramer (By similarity).
CC Homopentamerization is due to the presence of 4 residues in the BTB
CC (POZ) domain: Leu-56, Gly-100, Val-112 and Ala-118 (By similarity).
CC {ECO:0000250|UniProtKB:Q9NXV2}.
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DR EMBL; CH473948; EDM03804.1; -; Genomic_DNA.
DR EMBL; BC168712; AAI68712.1; -; mRNA.
DR RefSeq; NP_001099238.1; NM_001105768.1.
DR AlphaFoldDB; B5DEL1; -.
DR SMR; B5DEL1; -.
DR STRING; 10116.ENSRNOP00000073503; -.
DR PhosphoSitePlus; B5DEL1; -.
DR jPOST; B5DEL1; -.
DR PaxDb; 10116-ENSRNOP00000007850; -.
DR PeptideAtlas; B5DEL1; -.
DR Ensembl; ENSRNOT00000084991.2; ENSRNOP00000073503.1; ENSRNOG00000057186.2.
DR Ensembl; ENSRNOT00055045217; ENSRNOP00055037079; ENSRNOG00055026189.
DR Ensembl; ENSRNOT00060016390; ENSRNOP00060012807; ENSRNOG00060009714.
DR Ensembl; ENSRNOT00065016450; ENSRNOP00065012495; ENSRNOG00065010202.
DR GeneID; 287109; -.
DR KEGG; rno:287109; -.
DR UCSC; RGD:1304990; rat.
DR AGR; RGD:1304990; -.
DR CTD; 54442; -.
DR RGD; 1304990; Kctd5.
DR eggNOG; KOG2715; Eukaryota.
DR GeneTree; ENSGT00940000160374; -.
DR HOGENOM; CLU_070830_1_0_1; -.
DR InParanoid; B5DEL1; -.
DR OrthoDB; 54069at2759; -.
DR PhylomeDB; B5DEL1; -.
DR TreeFam; TF313754; -.
DR PRO; PR:B5DEL1; -.
DR Proteomes; UP000002494; Chromosome 10.
DR Proteomes; UP000234681; Chromosome 10.
DR Bgee; ENSRNOG00000057186; Expressed in jejunum and 18 other cell types or tissues.
DR Genevisible; B5DEL1; RN.
DR GO; GO:0031463; C:Cul3-RING ubiquitin ligase complex; IBA:GO_Central.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; ISS:UniProtKB.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0097602; F:cullin family protein binding; IBA:GO_Central.
DR GO; GO:0042802; F:identical protein binding; ISO:RGD.
DR GO; GO:0044877; F:protein-containing complex binding; ISO:RGD.
DR GO; GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR GO; GO:0051260; P:protein homooligomerization; IEA:InterPro.
DR CDD; cd18390; BTB_POZ_KCTD5; 1.
DR Gene3D; 3.30.70.2000; -; 1.
DR Gene3D; 6.10.140.750; -; 1.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR InterPro; IPR003131; T1-type_BTB.
DR PANTHER; PTHR14958:SF12; BTB_POZ DOMAIN-CONTAINING PROTEIN KCTD5; 1.
DR PANTHER; PTHR14958; POTASSIUM CHANNEL TETRAMERISATION DOMAIN CONTAINING PROTEIN; 1.
DR Pfam; PF02214; BTB_2; 1.
DR SMART; SM00225; BTB; 1.
DR SUPFAM; SSF54695; POZ domain; 1.
PE 2: Evidence at transcript level;
KW Acetylation; Cytoplasm; Nucleus; Reference proteome.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:Q9NXV2"
FT CHAIN 2..234
FT /note="BTB/POZ domain-containing protein KCTD5"
FT /id="PRO_0000390463"
FT DOMAIN 44..146
FT /note="BTB"
FT REGION 213..234
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0000250|UniProtKB:Q9NXV2"
SQ SEQUENCE 234 AA; 26164 MW; 05CCF56632DE4F3E CRC64;
MAENHCELLP PAPSGLGAGL GGGLCRRCSA GIGALAQRPS GVSKWVRLNV GGTYFLTTRQ
TLCRDPKSFL YRLCQADPDL DSDKDETGAY LIDRDPTYFG PVLNYLRHGK LVINRDLAEE
GVLEEAEFYN ITSLIKLVKD KIRERDSKTS QMPVKHVYRV LQCQEEELTQ MVSTMSDGWK
FEQLVSIGSS YNYGNEDQAE FLCVVSKELH NTPYGTTSEP SEKAKILQER GSRM
//
