ID KLH23_MOUSE Reviewed; 558 AA.
AC Q6GQU2; A2AR06; Q8C840;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2004, sequence version 1.
DT 24-JAN-2024, entry version 138.
DE RecName: Full=Kelch-like protein 23;
GN Name=Klhl23;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Head;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
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DR EMBL; AK048518; BAC33355.1; -; mRNA.
DR EMBL; AL845261; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC072626; AAH72626.1; -; mRNA.
DR CCDS; CCDS16100.1; -.
DR RefSeq; NP_808452.2; NM_177784.4.
DR RefSeq; XP_006499740.1; XM_006499677.1.
DR RefSeq; XP_006499741.1; XM_006499678.3.
DR AlphaFoldDB; Q6GQU2; -.
DR SMR; Q6GQU2; -.
DR BioGRID; 234936; 11.
DR STRING; 10090.ENSMUSP00000050219; -.
DR PhosphoSitePlus; Q6GQU2; -.
DR PaxDb; 10090-ENSMUSP00000050219; -.
DR ProteomicsDB; 263555; -.
DR Antibodypedia; 33817; 84 antibodies from 17 providers.
DR DNASU; 277396; -.
DR Ensembl; ENSMUST00000053087.4; ENSMUSP00000050219.4; ENSMUSG00000042155.4.
DR GeneID; 277396; -.
DR KEGG; mmu:277396; -.
DR UCSC; uc008jys.2; mouse.
DR AGR; MGI:2683536; -.
DR CTD; 151230; -.
DR MGI; MGI:2683536; Klhl23.
DR VEuPathDB; HostDB:ENSMUSG00000042155; -.
DR eggNOG; KOG4441; Eukaryota.
DR GeneTree; ENSGT00940000159106; -.
DR HOGENOM; CLU_004253_14_6_1; -.
DR InParanoid; Q6GQU2; -.
DR OMA; HIWDPIS; -.
DR OrthoDB; 5472491at2759; -.
DR PhylomeDB; Q6GQU2; -.
DR TreeFam; TF329218; -.
DR BioGRID-ORCS; 277396; 2 hits in 77 CRISPR screens.
DR ChiTaRS; Klhl23; mouse.
DR PRO; PR:Q6GQU2; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q6GQU2; Protein.
DR Bgee; ENSMUSG00000042155; Expressed in ureter smooth muscle and 220 other cell types or tissues.
DR Genevisible; Q6GQU2; MM.
DR CDD; cd18462; BACK_KLHL23; 1.
DR CDD; cd18252; BTB_POZ_KLHL23; 1.
DR Gene3D; 1.25.40.420; -; 1.
DR Gene3D; 2.120.10.80; Kelch-type beta propeller; 2.
DR InterPro; IPR011705; BACK.
DR InterPro; IPR017096; BTB-kelch_protein.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR030566; BTB_POZ_KLHL23.
DR InterPro; IPR015915; Kelch-typ_b-propeller.
DR InterPro; IPR006652; Kelch_1.
DR InterPro; IPR047068; KLHL23_BACK.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR PANTHER; PTHR24412; KELCH PROTEIN; 1.
DR PANTHER; PTHR24412:SF304; KELCH-LIKE PROTEIN 23; 1.
DR Pfam; PF07707; BACK; 1.
DR Pfam; PF00651; BTB; 1.
DR Pfam; PF01344; Kelch_1; 6.
DR PIRSF; PIRSF037037; Kelch-like_protein_gigaxonin; 1.
DR SMART; SM00875; BACK; 1.
DR SMART; SM00225; BTB; 1.
DR SMART; SM00612; Kelch; 6.
DR SUPFAM; SSF117281; Kelch motif; 1.
DR SUPFAM; SSF54695; POZ domain; 1.
DR PROSITE; PS50097; BTB; 1.
PE 2: Evidence at transcript level;
KW Kelch repeat; Reference proteome; Repeat.
FT CHAIN 1..558
FT /note="Kelch-like protein 23"
FT /id="PRO_0000242158"
FT DOMAIN 36..104
FT /note="BTB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT DOMAIN 139..240
FT /note="BACK"
FT REPEAT 274..320
FT /note="Kelch 1"
FT REPEAT 321..369
FT /note="Kelch 2"
FT REPEAT 370..416
FT /note="Kelch 3"
FT REPEAT 418..466
FT /note="Kelch 4"
FT REPEAT 467..508
FT /note="Kelch 5"
FT REPEAT 510..557
FT /note="Kelch 6"
FT CONFLICT 359
FT /note="R -> G (in Ref. 1; BAC33355)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 558 AA; 63840 MW; E338A317110DAAEA CRC64;
MALKGQEDYI FHFKDSSHPV DFLDAFRTFY MDGLFTDITL QCPSGIIFHC HRAVLAACSN
YFKAMFTADM KEKFKSKIKL SGIHHDILEG LVNYAYTSQI EITKRNVQSL LEAADLLQFL
SVKKACEQFL VRHLDIDNCI GMHSFAEFHV CSELEKESRR ILCSRFKEVW QQEEFLEISL
EKFLFILSRK NLSVWKEEAI LEPVIKWTAH DVENRIECIY NLLSYINIDI DPVYLKTALG
LQRSCLLTEN KIRSLIYNAL NPMHKEISQR STATMYIIGG YYWHPLSEVH IWDPLTNVWI
QGAEIPDYTR ESYGVTCLGP NIYVTGGYRT DNIDALDTVW IYNSEGDEWT EGLPMLNARY
YHCAVTLGGC VYALGGYRKG APAEEAEFYD PLKEKWLPIA NMIKGVGNAT ACVLHEVIYV
IGGHCGYRGS CTYDKVQSYN SDINEWSLIT ASPHPEYGLC SVPFENKLYL VGGQTTITEC
YDPEQNEWRE TAPMMERRME CGAVIMNGCI YVTGGYSYSK GTYLQSIEKY DPDLNKWEIV
GNLPSAMRSH GCVCVYNV
//
