ID KSTR2_MYCS2 Reviewed; 205 AA.
AC A0R4Z6; I7G9M3;
DT 08-FEB-2011, integrated into UniProtKB/Swiss-Prot.
DT 09-JAN-2007, sequence version 1.
DT 27-MAR-2024, entry version 100.
DE RecName: Full=HTH-type transcriptional repressor KstR2;
GN Name=kstR2; OrderedLocusNames=MSMEG_6009, MSMEI_5849;
OS Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium
OS smegmatis).
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycolicibacterium.
OX NCBI_TaxID=246196;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700084 / mc(2)155;
RA Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C.,
RA Fraser C.M.;
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700084 / mc(2)155;
RX PubMed=17295914; DOI=10.1186/gb-2007-8-2-r20;
RA Deshayes C., Perrodou E., Gallien S., Euphrasie D., Schaeffer C.,
RA Van-Dorsselaer A., Poch O., Lecompte O., Reyrat J.-M.;
RT "Interrupted coding sequences in Mycobacterium smegmatis: authentic
RT mutations or sequencing errors?";
RL Genome Biol. 8:R20.1-R20.9(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700084 / mc(2)155;
RX PubMed=18955433; DOI=10.1101/gr.081901.108;
RA Gallien S., Perrodou E., Carapito C., Deshayes C., Reyrat J.-M.,
RA Van Dorsselaer A., Poch O., Schaeffer C., Lecompte O.;
RT "Ortho-proteogenomics: multiple proteomes investigation through orthology
RT and a new MS-based protocol.";
RL Genome Res. 19:128-135(2009).
RN [4]
RP FUNCTION AS A TRANSCRIPTIONAL REPRESSOR.
RX PubMed=20167624; DOI=10.1099/mic.0.034538-0;
RA Kendall S.L., Burgess P., Balhana R., Withers M., Ten Bokum A., Lott J.S.,
RA Gao C., Uhia-Castro I., Stoker N.G.;
RT "Cholesterol utilization in mycobacteria is controlled by two TetR-type
RT transcriptional regulators: kstR and kstR2.";
RL Microbiology 156:1362-1371(2010).
CC -!- FUNCTION: Controls the expression of a small regulon that may play a
CC role in the utilization of cholesterol. {ECO:0000269|PubMed:20167624}.
CC -!- SUBUNIT: Homodimer. {ECO:0000250}.
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DR EMBL; CP000480; ABK75778.1; -; Genomic_DNA.
DR EMBL; CP001663; AFP42282.1; -; Genomic_DNA.
DR RefSeq; WP_003897410.1; NZ_SIJM01000017.1.
DR RefSeq; YP_890234.1; NC_008596.1.
DR AlphaFoldDB; A0R4Z6; -.
DR SMR; A0R4Z6; -.
DR STRING; 246196.MSMEG_6009; -.
DR PaxDb; 246196-MSMEI_5849; -.
DR GeneID; 66737294; -.
DR KEGG; msg:MSMEI_5849; -.
DR KEGG; msm:MSMEG_6009; -.
DR PATRIC; fig|246196.19.peg.5846; -.
DR eggNOG; COG1309; Bacteria.
DR OrthoDB; 9814200at2; -.
DR Proteomes; UP000000757; Chromosome.
DR Proteomes; UP000006158; Chromosome.
DR GO; GO:0003677; F:DNA binding; IMP:UniProtKB.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IMP:UniProtKB.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR Gene3D; 1.10.357.10; Tetracycline Repressor, domain 2; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001647; HTH_TetR.
DR InterPro; IPR041490; KstR2_TetR_C.
DR InterPro; IPR036271; Tet_transcr_reg_TetR-rel_C_sf.
DR PANTHER; PTHR30055; HTH-TYPE TRANSCRIPTIONAL REGULATOR RUTR; 1.
DR PANTHER; PTHR30055:SF253; HTH-TYPE TRANSCRIPTIONAL REPRESSOR KSTR2; 1.
DR Pfam; PF17932; TetR_C_24; 1.
DR Pfam; PF00440; TetR_N; 1.
DR PRINTS; PR00455; HTHTETR.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR SUPFAM; SSF48498; Tetracyclin repressor-like, C-terminal domain; 1.
DR PROSITE; PS50977; HTH_TETR_2; 1.
PE 1: Evidence at protein level;
KW DNA-binding; Reference proteome; Repressor; Transcription;
KW Transcription regulation.
FT CHAIN 1..205
FT /note="HTH-type transcriptional repressor KstR2"
FT /id="PRO_0000405032"
FT DOMAIN 10..70
FT /note="HTH tetR-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00335"
FT DNA_BIND 33..52
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00335"
SQ SEQUENCE 205 AA; 23306 MW; 8300989F65E1868E CRC64;
MAPDTPSQPA SRRDELLQLA ATMFADRGLK ATTVRDIADS AGILSGSLYH HFKSKEQMVE
EVLRDFLDWL FGRYQQILDT ATSPLEKLTG LFMASFEAIE HRHAQVVIYQ DEAKRLSDLP
QFDFVETRNK EQRKMWVDIL QEGVADGSFR PDLDVDLVYR FIRDTTWVSV RWYKPGGPLS
AEQVGQQYLA IVLGGITQSQ GDKHA
//
