ID KTHY_CAEEL Reviewed; 218 AA.
AC Q22018;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 27-MAR-2024, entry version 143.
DE RecName: Full=Thymidylate kinase {ECO:0000250|UniProtKB:P23919};
DE EC=2.7.4.9;
DE AltName: Full=dTMP kinase;
GN Name=dtmk-1 {ECO:0000312|WormBase:R53.2};
GN ORFNames=R53.2 {ECO:0000312|WormBase:R53.2};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: Catalyzes the conversion of dTMP to dTDP. {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + dTMP = ADP + dTDP; Xref=Rhea:RHEA:13517,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:58369, ChEBI:CHEBI:63528,
CC ChEBI:CHEBI:456216; EC=2.7.4.9;
CC -!- PATHWAY: Pyrimidine metabolism; dTTP biosynthesis.
CC -!- SIMILARITY: Belongs to the thymidylate kinase family. {ECO:0000305}.
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DR EMBL; Z66515; CAA91347.1; -; Genomic_DNA.
DR PIR; T24244; T24244.
DR RefSeq; NP_496151.1; NM_063750.3.
DR AlphaFoldDB; Q22018; -.
DR SMR; Q22018; -.
DR BioGRID; 39873; 10.
DR STRING; 6239.R53.2.2; -.
DR EPD; Q22018; -.
DR PaxDb; 6239-R53-2; -.
DR PeptideAtlas; Q22018; -.
DR EnsemblMetazoa; R53.2.1; R53.2.1; WBGene00011272.
DR GeneID; 174553; -.
DR KEGG; cel:CELE_R53.2; -.
DR UCSC; R53.2; c. elegans.
DR AGR; WB:WBGene00011272; -.
DR WormBase; R53.2; CE03571; WBGene00011272; dtmk-1.
DR eggNOG; KOG3327; Eukaryota.
DR GeneTree; ENSGT00940000154030; -.
DR HOGENOM; CLU_049131_3_1_1; -.
DR InParanoid; Q22018; -.
DR OMA; YWHQFDA; -.
DR OrthoDB; 5473102at2759; -.
DR PhylomeDB; Q22018; -.
DR UniPathway; UPA00575; -.
DR PRO; PR:Q22018; -.
DR Proteomes; UP000001940; Chromosome II.
DR Bgee; WBGene00011272; Expressed in embryo and 4 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004550; F:nucleoside diphosphate kinase activity; IBA:GO_Central.
DR GO; GO:0004798; F:thymidylate kinase activity; IBA:GO_Central.
DR GO; GO:0006233; P:dTDP biosynthetic process; IBA:GO_Central.
DR GO; GO:0006235; P:dTTP biosynthetic process; IBA:GO_Central.
DR GO; GO:0006227; P:dUDP biosynthetic process; IBA:GO_Central.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd01672; TMPK; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00165; Thymidylate_kinase; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR039430; Thymidylate_kin-like_dom.
DR InterPro; IPR018095; Thymidylate_kin_CS.
DR InterPro; IPR018094; Thymidylate_kinase.
DR NCBIfam; TIGR00041; DTMP_kinase; 1.
DR PANTHER; PTHR10344; THYMIDYLATE KINASE; 1.
DR PANTHER; PTHR10344:SF1; THYMIDYLATE KINASE; 1.
DR Pfam; PF02223; Thymidylate_kin; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS01331; THYMIDYLATE_KINASE; 1.
PE 3: Inferred from homology;
KW ATP-binding; Kinase; Nucleotide biosynthesis; Nucleotide-binding;
KW Reference proteome; Transferase.
FT CHAIN 1..218
FT /note="Thymidylate kinase"
FT /id="PRO_0000155212"
FT BINDING 15..22
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
SQ SEQUENCE 218 AA; 24342 MW; 28CBE4E8C8A38192 CRC64;
MATDQKRGLL IVFEGLDRSG KSTQAKRLVE SINKKSTESG DASSSPSAVL QAFPDRSSSI
GKLIDQYLRK EIDMDEHALH LLFSADRFSK NQMIRDNIAK GIDVICDRYC YSGVAYSLAK
GLPEQWVRSS DVGLPKPDAV LFFDVSPEVA AQRGGFGEER LETATIQQKV AAVMPTLRDD
AYWKTVNADG DLDSVEKNVF RIYENLDREK PFESLEKI
//
