ID KXD1_CANGA Reviewed; 203 AA.
AC Q6FS55;
DT 28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2004, sequence version 1.
DT 27-MAR-2024, entry version 82.
DE RecName: Full=Biogenesis of lysosome-related organelles complex 1 subunit KXD1;
DE Short=BLOC-1 subunit KXD1;
DE AltName: Full=KxDL homolog;
GN Name=KXD1; OrderedLocusNames=CAGL0H03355g;
OS Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 /
OS NRRL Y-65 / CBS 138) (Yeast) (Nakaseomyces glabratus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Nakaseomyces.
OX NCBI_TaxID=284593;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138;
RX PubMed=15229592; DOI=10.1038/nature02579;
RA Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA Weissenbach J., Wincker P., Souciet J.-L.;
RT "Genome evolution in yeasts.";
RL Nature 430:35-44(2004).
CC -!- FUNCTION: Component of the biogenesis of lysosome-related organelles
CC complex-1 (BLOC-1) involved in endosomal cargo sorting. {ECO:0000250}.
CC -!- SUBUNIT: Component of the biogenesis of lysosome-related organelles
CC complex-1 (BLOC-1). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Endosome {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the KXD1 family. {ECO:0000305}.
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DR EMBL; CR380954; CAG59872.1; -; Genomic_DNA.
DR RefSeq; XP_446939.1; XM_446939.1.
DR AlphaFoldDB; Q6FS55; -.
DR SMR; Q6FS55; -.
DR STRING; 284593.Q6FS55; -.
DR EnsemblFungi; CAGL0H03355g-T; CAGL0H03355g-T-p1; CAGL0H03355g.
DR GeneID; 2888863; -.
DR KEGG; cgr:CAGL0H03355g; -.
DR CGD; CAL0132014; CAGL0H03355g.
DR VEuPathDB; FungiDB:B1J91_H03355g; -.
DR VEuPathDB; FungiDB:CAGL0H03355g; -.
DR eggNOG; ENOG502S1H5; Eukaryota.
DR HOGENOM; CLU_099155_0_0_1; -.
DR InParanoid; Q6FS55; -.
DR OMA; TPMFDTS; -.
DR Proteomes; UP000002428; Chromosome H.
DR GO; GO:0031083; C:BLOC-1 complex; IEA:EnsemblFungi.
DR GO; GO:0005768; C:endosome; IEA:UniProtKB-SubCell.
DR GO; GO:0009318; C:exodeoxyribonuclease VII complex; IEA:InterPro.
DR GO; GO:0008855; F:exodeoxyribonuclease VII activity; IEA:InterPro.
DR GO; GO:0006308; P:DNA catabolic process; IEA:InterPro.
DR GO; GO:0007032; P:endosome organization; IEA:EnsemblFungi.
DR GO; GO:0032880; P:regulation of protein localization; IEA:EnsemblFungi.
DR InterPro; IPR037004; Exonuc_VII_ssu_sf.
DR InterPro; IPR019371; KxDL_dom.
DR PANTHER; PTHR37787; BIOGENESIS OF LYSOSOME-RELATED ORGANELLES COMPLEX 1 SUBUNIT KXD1; 1.
DR PANTHER; PTHR37787:SF1; BIOGENESIS OF LYSOSOME-RELATED ORGANELLES COMPLEX 1 SUBUNIT KXD1; 1.
DR Pfam; PF10241; KxDL; 1.
DR SUPFAM; SSF116842; XseB-like; 1.
PE 3: Inferred from homology;
KW Coiled coil; Endosome; Reference proteome; Transport.
FT CHAIN 1..203
FT /note="Biogenesis of lysosome-related organelles complex 1
FT subunit KXD1"
FT /id="PRO_0000410667"
FT REGION 1..62
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 126..178
FT /evidence="ECO:0000255"
FT COMPBIAS 15..29
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 203 AA; 22824 MW; 17EA12EE4659FFC4 CRC64;
MSDEIEDRPR TRSRTPSVDT QSYTINEEAH HIITDSDSSS SENEDGEGNE TNSSDDSSES
GSVERFLDEI VPTTSTSFIP NDTPDPATLF DITEYIFDSI VQSTNACDFS EAFALQAKTS
AVINSKSMEL KNLIEQTKVR LPELQAKFKN GTQTLRTIRK NLDNAKSRIQ VMNDVLQTDY
PIEFNQARDK ILERTLDSDE EVI
//
