ID L0AH67_NATGS Unreviewed; 765 AA.
AC L0AH67;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE SubName: Full=DUF4129 domain-containing protein {ECO:0000313|EMBL:PLK21647.1};
DE SubName: Full=Transglutaminase {ECO:0000313|EMBL:AFZ73238.1, ECO:0000313|EMBL:ELY71303.1};
GN OrderedLocusNames=Natgr_2055 {ECO:0000313|EMBL:AFZ73238.1};
GN ORFNames=C490_05212 {ECO:0000313|EMBL:ELY71303.1}, CYV19_03555
GN {ECO:0000313|EMBL:PLK21647.1};
OS Natronobacterium gregoryi (strain ATCC 43098 / DSM 3393 / CCM 3738 / CIP
OS 104747 / IAM 13177 / JCM 8860 / NBRC 102187 / NCIMB 2189 / SP2).
OC Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Natrialbales;
OC Natrialbaceae; Natronobacterium.
OX NCBI_TaxID=797304 {ECO:0000313|EMBL:AFZ73238.1, ECO:0000313|Proteomes:UP000010468};
RN [1] {ECO:0000313|Proteomes:UP000010468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 43098 / CCM 3738 / NCIMB 2189 / SP2
RC {ECO:0000313|Proteomes:UP000010468};
RA Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA Peters L., Mikhailova N., Teshima H., Detter J.C., Han C., Tapia R.,
RA Land M., Hauser L., Kyrpides N., Ivanova N., Pagani I., Sproer C.,
RA Anderson I., Woyke T.;
RT "Complete sequence of Natronobacterium gregoryi SP2.";
RL Submitted (MAR-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AFZ73238.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=SP2 {ECO:0000313|EMBL:AFZ73238.1};
RG US DOE Joint Genome Institute;
RA Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA Peters L., Mikhailova N., Teshima H., Detter J.C., Han C., Tapia R.,
RA Land M., Hauser L., Kyrpides N., Ivanova N., Pagani I., Sproer C.,
RA Anderson I., Woyke T.;
RT "Complete sequence of Natronobacterium gregoryi SP2.";
RL Submitted (MAR-2012) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:ELY71303.1, ECO:0000313|Proteomes:UP000011613}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SP2 {ECO:0000313|EMBL:ELY71303.1,
RC ECO:0000313|Proteomes:UP000011613};
RX PubMed=25393412; DOI=10.1371/journal.pgen.1004784;
RA Becker E.A., Seitzer P.M., Tritt A., Larsen D., Krusor M., Yao A.I., Wu D.,
RA Madern D., Eisen J.A., Darling A.E., Facciotti M.T.;
RT "Phylogenetically driven sequencing of extremely halophilic archaea reveals
RT strategies for static and dynamic osmo-response.";
RL PLoS Genet. 10:E1004784-E1004784(2014).
RN [4] {ECO:0000313|EMBL:PLK21647.1, ECO:0000313|Proteomes:UP000234484}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SP2 {ECO:0000313|EMBL:PLK21647.1,
RC ECO:0000313|Proteomes:UP000234484};
RC TISSUE=Freeze-dried powder thallus {ECO:0000313|EMBL:PLK21647.1};
RA Jiang L., He B., Kang J., Yu M., Li N., Fang Y., Tang Z., Wu P., Yao P.,
RA Huang J.;
RT "The characterization of oligonucleotides binding to NgAgo.";
RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; CP003377; AFZ73238.1; -; Genomic_DNA.
DR EMBL; AOIC01000044; ELY71303.1; -; Genomic_DNA.
DR EMBL; PKKI01000007; PLK21647.1; -; Genomic_DNA.
DR RefSeq; WP_005577491.1; NZ_PKKI01000007.1.
DR AlphaFoldDB; L0AH67; -.
DR STRING; 797304.Natgr_2055; -.
DR GeneID; 14207922; -.
DR KEGG; nge:Natgr_2055; -.
DR PATRIC; fig|797304.7.peg.1046; -.
DR eggNOG; arCOG02169; Archaea.
DR HOGENOM; CLU_022005_0_0_2; -.
DR Proteomes; UP000010468; Chromosome.
DR Proteomes; UP000011613; Unassembled WGS sequence.
DR Proteomes; UP000234484; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0008233; F:peptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 3.10.620.30; -; 1.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR025403; TgpA-like_C.
DR InterPro; IPR021878; TgpA_N.
DR InterPro; IPR002931; Transglutaminase-like.
DR PANTHER; PTHR42736; PROTEIN-GLUTAMINE GAMMA-GLUTAMYLTRANSFERASE; 1.
DR PANTHER; PTHR42736:SF1; PROTEIN-GLUTAMINE GAMMA-GLUTAMYLTRANSFERASE; 1.
DR Pfam; PF13559; DUF4129; 1.
DR Pfam; PF11992; TgpA_N; 1.
DR Pfam; PF01841; Transglut_core; 1.
DR SMART; SM00460; TGc; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000313|EMBL:AFZ73238.1};
KW Membrane {ECO:0000256|SAM:Phobius}; Protease {ECO:0000313|EMBL:AFZ73238.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000010468};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 28..48
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 54..76
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 83..100
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 139..158
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 163..180
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 186..204
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 216..234
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 462..531
FT /note="Transglutaminase-like"
FT /evidence="ECO:0000259|SMART:SM00460"
FT REGION 525..544
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 549..628
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 555..590
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 765 AA; 82047 MW; E23A78C56572B266 CRC64;
MSPDASRTTA DGARSIALET DEPIGPGAFR LLALGCVLVL TASYVSVLQD VTRVVGGTQT
LLALVGGMLL AATILARAIR PRTATLLAVV AAGLGFGYYL ERTDVGIEIL FTASDAIEML
AVDVVTLLTG LELLRMVEAG IWTLGFVPGP VFLSWYLALR GRYGLSVLPG GFALLFLVLT
GDAGTAATLV GILAALGAVA FGDFERRGGS VTQADLLAVL FAVIVALSLS VTFVPGGAST
GGVTTGAGGD GTLEGAMDSA SERSGIAGQV DLSPEVRFTV ESTHPSYWRT GVYDRYTGDE
WVRTGQSYAL EQGVLAEPSG TTDRMRQTVT IETDLGVLPA AAEPVYVDGD VTDYTEVSSH
GHIQPATTLI EGDAYTVESA VVDPSPAELQ TAGTEYPDEI EDHYLQTPET LSEEFEERTE
SVTDGAETPY ETANAIETYL RSSKAYSLEV ERPAGDVAEA FLFEMDEGYC VYFATTMAQM
LRTEGVPARY VTGYTSGEQD GNEFIVRGTD AHAWVEVYFP DQGWVTFEPT PPQPREEEHT
ERLADARQGD AELDPADVEN DGGAEDDSGP GDDGSNESDS DGDELEPSDS TSNETDGTPD
EADPQSVDAT PPDLGEPNET VTQRDEVTPP VPLTRELLVV ASVFLVGAIA AVHRVDATVR
ARRLLGRYWQ RRTDDPDRDA ERAFRRLESL LGATYRPRRP GESARGYVRA LADEHELDPR
TERVVDRYEQ AVYGGGVGRE EADRAIELVD ELARNRLPLA GRSRN
//
