ID L0AIH3_NATGS Unreviewed; 503 AA.
AC L0AIH3;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE RecName: Full=Multidrug-efflux transporter {ECO:0000256|ARBA:ARBA00031636};
GN OrderedLocusNames=Natgr_2522 {ECO:0000313|EMBL:AFZ73683.1};
GN ORFNames=CYV19_14030 {ECO:0000313|EMBL:PLK19551.1};
OS Natronobacterium gregoryi (strain ATCC 43098 / DSM 3393 / CCM 3738 / CIP
OS 104747 / IAM 13177 / JCM 8860 / NBRC 102187 / NCIMB 2189 / SP2).
OC Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Natrialbales;
OC Natrialbaceae; Natronobacterium.
OX NCBI_TaxID=797304 {ECO:0000313|EMBL:AFZ73683.1, ECO:0000313|Proteomes:UP000010468};
RN [1] {ECO:0000313|EMBL:AFZ73683.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=SP2 {ECO:0000313|EMBL:AFZ73683.1};
RG US DOE Joint Genome Institute;
RA Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA Peters L., Mikhailova N., Teshima H., Detter J.C., Han C., Tapia R.,
RA Land M., Hauser L., Kyrpides N., Ivanova N., Pagani I., Sproer C.,
RA Anderson I., Woyke T.;
RT "Complete sequence of Natronobacterium gregoryi SP2.";
RL Submitted (MAR-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000010468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 43098 / CCM 3738 / NCIMB 2189 / SP2
RC {ECO:0000313|Proteomes:UP000010468};
RA Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA Peters L., Mikhailova N., Teshima H., Detter J.C., Han C., Tapia R.,
RA Land M., Hauser L., Kyrpides N., Ivanova N., Pagani I., Sproer C.,
RA Anderson I., Woyke T.;
RT "Complete sequence of Natronobacterium gregoryi SP2.";
RL Submitted (MAR-2012) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:PLK19551.1, ECO:0000313|Proteomes:UP000234484}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SP2 {ECO:0000313|EMBL:PLK19551.1,
RC ECO:0000313|Proteomes:UP000234484};
RC TISSUE=Freeze-dried powder thallus {ECO:0000313|EMBL:PLK19551.1};
RA Jiang L., He B., Kang J., Yu M., Li N., Fang Y., Tang Z., Wu P., Yao P.,
RA Huang J.;
RT "The characterization of oligonucleotides binding to NgAgo.";
RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; CP003377; AFZ73683.1; -; Genomic_DNA.
DR EMBL; PKKI01000046; PLK19551.1; -; Genomic_DNA.
DR RefSeq; WP_015233640.1; NZ_PKKI01000046.1.
DR AlphaFoldDB; L0AIH3; -.
DR STRING; 797304.Natgr_2522; -.
DR GeneID; 14208389; -.
DR KEGG; nge:Natgr_2522; -.
DR eggNOG; arCOG01731; Archaea.
DR HOGENOM; CLU_012893_5_3_2; -.
DR Proteomes; UP000010468; Chromosome.
DR Proteomes; UP000234484; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0006811; P:monoatomic ion transport; IEA:UniProtKB-KW.
DR CDD; cd13137; MATE_NorM_like; 1.
DR InterPro; IPR002528; MATE_fam.
DR InterPro; IPR048279; MdtK-like.
DR NCBIfam; TIGR00797; matE; 1.
DR PANTHER; PTHR43298:SF2; FMN_FAD EXPORTER YEEO-RELATED; 1.
DR PANTHER; PTHR43298; MULTIDRUG RESISTANCE PROTEIN NORM-RELATED; 1.
DR Pfam; PF01554; MatE; 2.
DR PIRSF; PIRSF006603; DinF; 1.
PE 4: Predicted;
KW Antiport {ECO:0000256|ARBA:ARBA00022449};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000010468};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 52..71
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 77..96
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 116..133
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 153..171
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 192..212
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 218..237
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 342..369
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 375..397
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 418..438
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 458..480
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 503 AA; 52225 MW; C5FA5CB250611C32 CRC64;
MGRRFPNPIR LAILWIGLAL AKLGLIEAER ARRTTDLAWP RVVTGLARMS KNAVDVAMVG
IGVGSAAIAG VGFATPFWGL AFALGGGVAG GTIALVSQRY GAEAFDQLGQ AIRSSALLVV
GITLPITVTF WYVPTELISL LSSNPEAIEP GATYLQIVGL GVPFAGLNLI GSRTFVGMDD
AWTPMVVRAG GAVVNIVLNA ALIFGLGMGV SGAAIGTVLA NVAVTATFAV GLVAGWLPGA
GKFPVSVDPL GSYLHESTIR DLTAIGLPVL GTKLVWTAAE FPLLAIVDLF GQDTVSAYVI
ARRIWGLMNT PGWGFGLAAS SLVGQELGTG DERRAERFGT EIVLFATAVY AVGAVIVFAF
AEPIVLLFTD DPAELAVGTT VALVQVACFA ILLKGVATGA SGALKASGDT KWPFYSQLLG
MFGLAIPFAY LGAAGLTLPS ATVPVLEVTV PGVSIAPIGL LGLYLAFLAE TLVPAVINYY
RFWTGRWKEI SRGYRPDAAP SDD
//
