ID   L0AVY0_THEEQ            Unreviewed;       780 AA.
AC   L0AVY0;
DT   06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT   06-MAR-2013, sequence version 1.
DT   27-MAR-2024, entry version 35.
DE   RecName: Full=SPX domain-containing protein {ECO:0008006|Google:ProtNLM};
GN   ORFNames=BEWA_018990 {ECO:0000313|EMBL:AFZ79054.1};
OS   Theileria equi strain WA.
OC   Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Piroplasmida;
OC   Theileriidae; Theileria.
OX   NCBI_TaxID=1537102 {ECO:0000313|EMBL:AFZ79054.1, ECO:0000313|Proteomes:UP000031512};
RN   [1] {ECO:0000313|EMBL:AFZ79054.1, ECO:0000313|Proteomes:UP000031512}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=WA {ECO:0000313|EMBL:AFZ79054.1,
RC   ECO:0000313|Proteomes:UP000031512};
RX   PubMed=23137308; DOI=10.1186/1471-2164-13-603;
RA   Kappmeyer L.S., Thiagarajan M., Herndon D.R., Ramsay J.D., Caler E.,
RA   Djikeng A., Gillespie J.J., Lau A.O., Roalson E.H., Silva J.C., Silva M.G.,
RA   Suarez C.E., Ueti M.W., Nene V.M., Mealey R.H., Knowles D.P., Brayton K.A.;
RT   "Comparative genomic analysis and phylogenetic position of Theileria
RT   equi.";
RL   BMC Genomics 13:603-603(2012).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the SYG1 (TC 2.A.94) family.
CC       {ECO:0000256|ARBA:ARBA00009665}.
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DR   EMBL; CP001669; AFZ79054.1; -; Genomic_DNA.
DR   RefSeq; XP_004828720.1; XM_004828663.1.
DR   AlphaFoldDB; L0AVY0; -.
DR   STRING; 1537102.L0AVY0; -.
DR   EnsemblProtists; AFZ79054; AFZ79054; BEWA_018990.
DR   GeneID; 15805921; -.
DR   KEGG; beq:BEWA_018990; -.
DR   VEuPathDB; PiroplasmaDB:BEWA_018990; -.
DR   eggNOG; KOG1162; Eukaryota.
DR   OrthoDB; 7162at2759; -.
DR   Proteomes; UP000031512; Chromosome 1.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR004342; EXS_C.
DR   InterPro; IPR004331; SPX_dom.
DR   PANTHER; PTHR10783:SF103; XENOTROPIC AND POLYTROPIC RETROVIRUS RECEPTOR 1; 1.
DR   PANTHER; PTHR10783; XENOTROPIC AND POLYTROPIC RETROVIRUS RECEPTOR 1-RELATED; 1.
DR   Pfam; PF03124; EXS; 1.
DR   Pfam; PF03105; SPX; 1.
DR   PROSITE; PS51380; EXS; 1.
DR   PROSITE; PS51382; SPX; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000031512};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        396..426
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        459..481
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        493..509
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        615..634
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        646..669
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        689..707
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        719..742
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          1..342
FT                   /note="SPX"
FT                   /evidence="ECO:0000259|PROSITE:PS51382"
FT   DOMAIN          576..775
FT                   /note="EXS"
FT                   /evidence="ECO:0000259|PROSITE:PS51380"
SQ   SEQUENCE   780 AA;  89717 MW;  CE51C4636DC568D9 CRC64;
     MKFGSKLESF LVKEWADKYV RYKYLNRLIK GAKKFEVENK NKDEGTILES SLFPGDSVGD
     PKDVKFDTPQ YYSDHVSVEI SPENEGEENK TLPNDASSFQ YHYVDDEDNS DKILNVIKLM
     ASQFEEYGHL SFCEVSVKDR LDSHSKLSSV TKRKNTLGDI IDKLESESVI GISSDVSFSD
     KGVKFPRVKA KIPQRAHKSF RLSRHPKKKK SVYKSSVKLG STKLKIFGNI PLPFRRQKET
     TSEYLSLFNK SLRDDIRTVI LHYTSEMEYI QTLIKYLRRD IRRRQGKIDN SYVKLVQKAA
     TALWDSCDKL QSYLNVNILA VYKLLKKKDK LLGTNDLTNV YPSYKGVLLS VDNCKETNDK
     ILALFDMVSP PSNVDFIKLK EGVETSLSVN KGNYYYLSYV LGLSTMLLLA CVFLCSFFFV
     CSLIWWGCGW CQNYLEIYGV NYQFMFGLSN NYSISDKDFY FFGALQSLLC LALFCFLLLD
     CKLLIVGSHS RHFSYPITLI TFSILVMLLP NKNFKLKLRK KLLLSCGRLF TSSFGIGAPV
     TLVDSILADI LTSLTRPLSD FLYIFSYFSY GISHDSHRMH DGKSMLSQYV IPQPYQGGSY
     LWWISERRKL HVGNMLKYIS AMSCIVISSI NWTYVADLSS STSNAIVVTF YTFATLFNFL
     WDYFIDWGLS LPPNILKGRN GRIMYTRKAY YIACVINLSC RCTWALTTSP LQLISNKELS
     SNLLVLIVSV IEIFRRIVWV AFRLESEHLL NSYKYRTALW IPKLYNCKSV LVNELTMLNQ
//