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Database: UniProt
Entry: L0DUV7_THIND
LinkDB: L0DUV7_THIND
Original site: L0DUV7_THIND 
ID   L0DUV7_THIND            Unreviewed;       577 AA.
AC   L0DUV7;
DT   06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT   06-MAR-2013, sequence version 1.
DT   12-SEP-2018, entry version 40.
DE   RecName: Full=Malto-oligosyltrehalose trehalohydrolase {ECO:0000256|PIRNR:PIRNR006337};
DE            Short=MTHase {ECO:0000256|PIRNR:PIRNR006337};
DE            EC=3.2.1.141 {ECO:0000256|PIRNR:PIRNR006337};
DE   AltName: Full=4-alpha-D-((1->4)-alpha-D-glucano)trehalose trehalohydrolase {ECO:0000256|PIRNR:PIRNR006337};
DE   AltName: Full=Maltooligosyl trehalose trehalohydrolase {ECO:0000256|PIRNR:PIRNR006337};
GN   Name=treZ [H] {ECO:0000313|EMBL:AGA32792.1};
GN   OrderedLocusNames=TVNIR_1113 {ECO:0000313|EMBL:AGA32792.1};
OS   Thioalkalivibrio nitratireducens (strain DSM 14787 / UNIQEM 213 /
OS   ALEN2).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Chromatiales;
OC   Ectothiorhodospiraceae; Thioalkalivibrio.
OX   NCBI_TaxID=1255043 {ECO:0000313|EMBL:AGA32792.1, ECO:0000313|Proteomes:UP000010809};
RN   [1] {ECO:0000313|Proteomes:UP000010809}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 14787 / UNIQEM 213 / ALEN2
RC   {ECO:0000313|Proteomes:UP000010809};
RA   Tikhonova T.V., Pavlov A.R., Beletsky A.V., Mardanov A.V.,
RA   Sorokin D.Y., Ravin N.V., Popov V.O.;
RT   "Complete sequence of Thioalkalivibrio nitratireducens.";
RL   Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: Hydrolysis of (1->4)-alpha-D-glucosidic
CC       linkage in 4-alpha-D-((1->4)-alpha-D-glucanosyl)(n) trehalose to
CC       yield trehalose and (1->4)-alpha-D-glucan.
CC       {ECO:0000256|PIRNR:PIRNR006337}.
CC   -!- PATHWAY: Glycan biosynthesis; trehalose biosynthesis.
CC       {ECO:0000256|PIRNR:PIRNR006337}.
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 13 family.
CC       {ECO:0000256|PIRNR:PIRNR006337, ECO:0000256|SAAS:SAAS00964676}.
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DR   EMBL; CP003989; AGA32792.1; -; Genomic_DNA.
DR   RefSeq; WP_015257930.1; NC_019902.2.
DR   ProteinModelPortal; L0DUV7; -.
DR   EnsemblBacteria; AGA32792; AGA32792; TVNIR_1113.
DR   KEGG; tni:TVNIR_1113; -.
DR   PATRIC; fig|1255043.3.peg.1124; -.
DR   KO; K01236; -.
DR   OrthoDB; POG091H0CAL; -.
DR   BioCyc; TNIT1255043:G1HDO-1082-MONOMER; -.
DR   UniPathway; UPA00299; -.
DR   Proteomes; UP000010809; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0033942; F:4-alpha-D-(1->4)-alpha-D-glucanotrehalose trehalohydrolase activity; IEA:UniProtKB-EC.
DR   GO; GO:0005992; P:trehalose biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 2.60.40.10; -; 1.
DR   InterPro; IPR022567; DUF3459.
DR   InterPro; IPR006047; Glyco_hydro_13_cat_dom.
DR   InterPro; IPR017853; Glycoside_hydrolase_SF.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR012768; Trehalose_TreZ.
DR   Pfam; PF00128; Alpha-amylase; 2.
DR   Pfam; PF11941; DUF3459; 1.
DR   PIRSF; PIRSF006337; Trehalose_TreZ; 1.
DR   SMART; SM00642; Aamy; 1.
DR   SUPFAM; SSF51445; SSF51445; 1.
DR   SUPFAM; SSF81296; SSF81296; 1.
DR   TIGRFAMs; TIGR02402; trehalose_TreZ; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000010809};
KW   Glycosidase {ECO:0000256|PIRNR:PIRNR006337,
KW   ECO:0000313|EMBL:AGA32792.1};
KW   Hydrolase {ECO:0000256|PIRNR:PIRNR006337,
KW   ECO:0000313|EMBL:AGA32792.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000010809}.
FT   DOMAIN       79    444       Aamy. {ECO:0000259|SMART:SM00642}.
FT   COILED      259    279       {ECO:0000256|SAM:Coils}.
FT   ACT_SITE    245    245       Nucleophile. {ECO:0000256|PIRSR:
FT                                PIRSR006337-1}.
FT   ACT_SITE    282    282       Proton donor. {ECO:0000256|PIRSR:
FT                                PIRSR006337-1}.
FT   SITE        376    376       Transition state stabilizer.
FT                                {ECO:0000256|PIRSR:PIRSR006337-3}.
SQ   SEQUENCE   577 AA;  63787 MW;  22BAD7780CC83A23 CRC64;
     MTVLRVWAPD AEQVVLECGG TDTPMACGDG GWWTLEASPL AHGVDYGFRL DGDGPFPDPR
     SRWQPEGVHG PSRWVDHTRF EWSDAGWQAP PLSAAVIAEI HVGTLTPAGT FDAVIDRLDH
     LVALGITHVE LMPVQEFPGT RGWGYDGVDL FAPHHAYGGP DGLKRLVDAC HRRGLAVLLD
     VVYNHLGPDG NYLARFGPYF TDAYHTPWGD AVNLDRAHSD EVRRFFLDNA RMWLRDYHFD
     GLRIDAIHAI VDTSATHFLE ALSAEVRRLE AELGRHLVLI AESDLNDPRT VRPVAIGGHG
     LDAQWNEDFH HALHAALTGE SGGYYADFGR LADLARVLTR GFAYDGAYSR YRRRNHGRAA
     TGVPGRRFVG CLQNHDQVGN RAAGERSSHL LSPELLKVGA ALVLTSPFVP MLFQGEEWGA
     TTPFLYFTDH SDPELGAAVR DGRRKEFAAF GWDPEGIPDP QARETFERSR LDWDERSRAP
     HAELLEWHRR LIALRRGHPA FADDRLEPIR VHFDDGRRWL VMLRPGIVVA CNLAGDAQRL
     DCPEAAGCGV LLGSNPGVAR EGSTLVLPGE SVAVLCD
//
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