ID L0EY94_LIBCB Unreviewed; 1179 AA.
AC L0EY94;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
DE AltName: Full=DNA 3'-5' helicase II {ECO:0000256|ARBA:ARBA00034923};
GN OrderedLocusNames=B488_13640 {ECO:0000313|EMBL:AGA65356.1};
OS Liberibacter crescens (strain BT-1).
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales;
OC Rhizobiaceae; Liberibacter.
OX NCBI_TaxID=1215343 {ECO:0000313|EMBL:AGA65356.1, ECO:0000313|Proteomes:UP000010799};
RN [1] {ECO:0000313|EMBL:AGA65356.1, ECO:0000313|Proteomes:UP000010799}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BT-1 {ECO:0000313|EMBL:AGA65356.1,
RC ECO:0000313|Proteomes:UP000010799};
RX PubMed=23408754; DOI=10.4056/sigs.3326772;
RA Leonard M.T., Fagen J.R., Davis-Richardson A.G., Davis M.J., Triplett E.W.;
RT "Complete genome sequence of Liberibacter crescens BT-1.";
RL Stand. Genomic Sci. 7:271-283(2012).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
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DR EMBL; CP003789; AGA65356.1; -; Genomic_DNA.
DR RefSeq; WP_015273781.1; NC_019907.1.
DR AlphaFoldDB; L0EY94; -.
DR STRING; 1215343.B488_13640; -.
DR KEGG; lcc:B488_13640; -.
DR PATRIC; fig|1215343.11.peg.1408; -.
DR eggNOG; COG1074; Bacteria.
DR HOGENOM; CLU_001114_0_0_5; -.
DR Proteomes; UP000010799; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-UniRule.
DR Gene3D; 3.90.320.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR InterPro; IPR014151; DNA_helicase_AddA.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011604; PDDEXK-like_dom_sf.
DR InterPro; IPR011335; Restrct_endonuc-II-like.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR NCBIfam; TIGR02784; addA_alphas; 1.
DR PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52980; Restriction endonuclease-like; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000010799}.
FT DOMAIN 17..496
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 521..805
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT BINDING 38..45
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 1179 AA; 135503 MW; D683942BB210594B CRC64;
MKNDILSKTI SKTEDWINWT EKQQSLASDP RRSVWVSANA GSGKTHVLAQ RVIRLLLAKY
KPSSLLCLTY TKEAASEMSN RVFEKLAEWT CLSDDELSKQ IIKIEGKEPD KKKLIEARNL
FIKALETPGG LKVQTIHAFC EAILQQFPLE ANIAGHFSVI DDLSKQKIIQ EAQQLMLSSI
AKDTNSLLNK SFKRIIDLVD EKEITELISQ IVTHRHALKS FFSFAAVNGG EEAVLRDRFG
LEKQQDYTKL LSNLWPLPNF EYKEFVKLLR EDNGIKALER AEILEKSALE IDPLQRFELI
KRIFLTQELQ PHKRIITKYI KEKAPHLEKT IKNLQEYIFT FCNHFNIAKM MEHTLLVLNF
ANNFIVKHEE LKAKYSVLDF EDLIIRTAHL LKKSDVGAWI RYKLDQAIDH ILIDEVQDTS
PIQWEVIRAL TEDFFSGENA HLRTLFAVGD RKQSIYSFQG ARADRFSLES QITRSHVINS
GQLFSTVQLP LSFRSTADIL SAVDKVFSFK ENAKGLATES KDIIHHSNRI GEPGTVDVWE
TIFSEKNPKQ EDDWVSYFKH IPQNAPSVIL AQRIADTILN MIENVTIINN GKKRLIVPGD
ILILVRKRNS FINCLTRILK NSNKIPVSGP DKLNLTDHIA VQDLIALGRV ILSQEDDLSL
ASLLKSPLFS LSEDEIFELS AMRKTSESVF SHLNRLATAG HPVFIGVWDK LNSLIILSQS
CSAYDFFSLT LGQKGGRKNF LARFGNEIND ILDEFMNFAL KKEQDGFITL QEFISIIEKE
APIIKRQHNQ NFNEVRIMTV HASKGLEAPV VFLVDAGTKA FSKQHVKKLR LLTSDNNQNE
TSIPVWIPSS DFDNTVNSED LNCLKNLEQE EYHRLLYVGM TRAADRLIIC GYGSTKNNEG
TWSDIVTKAF TGDERAKETT FYGLNETWKG LQWRTYCTEQ VPFEDEIFKP KFEDTKKIPE
ELLIPPENQY ILPYFINPSN IENIGPSPLI PRLFNEKPLN NYSLRRGRMI HKLLQIIFDI
PEEDSKKYIL SYCNYNTRLW PKKESEKLIS SFIDIIKYPS IPSSIEYTSC AEVSIAGKIS
FKNRDFFVAG RVDRMFISEE KIFLLEYKTN HIFPKLQSEI PISHISQLSI YREVLKPLYP
NKQFECLLIY TQEPKVFTLS NSQLENSLIQ IENKFYYSS
//
