ID L0H8X7_METFS Unreviewed; 630 AA.
AC L0H8X7;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE RecName: Full=acetate--CoA ligase {ECO:0000256|ARBA:ARBA00013275};
DE EC=6.2.1.1 {ECO:0000256|ARBA:ARBA00013275};
GN OrderedLocusNames=Metfor_0086 {ECO:0000313|EMBL:AGB01172.1};
OS Methanoregula formicica (strain DSM 22288 / NBRC 105244 / SMSP).
OC Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC Methanomicrobiales; Methanoregulaceae; Methanoregula.
OX NCBI_TaxID=593750 {ECO:0000313|EMBL:AGB01172.1, ECO:0000313|Proteomes:UP000010824};
RN [1] {ECO:0000313|Proteomes:UP000010824}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 22288 / NBRC 105244 / SMSP
RC {ECO:0000313|Proteomes:UP000010824};
RA Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA Peters L., Ovchinnikova G., Teshima H., Detter J.C., Han C., Tapia R.,
RA Land M., Hauser L., Kyrpides N., Ivanova N., Pagani I., Imachi H.,
RA Tamaki H., Sekiguchi Y., Kamagata Y., Cadillo-Quiroz H., Zinder S.,
RA Liu W.-T., Woyke T.;
RT "Complete sequence of Methanoregula formicicum SMSP.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AGB01172.1, ECO:0000313|Proteomes:UP000010824}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 22288 / NBRC 105244 / SMSP
RC {ECO:0000313|Proteomes:UP000010824};
RX PubMed=25189582;
RA Yamamoto K., Tamaki H., Cadillo-Quiroz H., Imachi H., Kyrpides N.,
RA Woyke T., Goodwin L., Zinder S.H., Kamagata Y., Liu W.T.;
RT "Complete Genome Sequence of Methanoregula formicica SMSPT, a Mesophilic
RT Hydrogenotrophic Methanogen Isolated from a Methanogenic Upflow Anaerobic
RT Sludge Blanket Reactor.";
RL Genome Announc. 2:e00870-14(2014).
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DR EMBL; CP003167; AGB01172.1; -; Genomic_DNA.
DR RefSeq; WP_015284136.1; NC_019943.1.
DR AlphaFoldDB; L0H8X7; -.
DR STRING; 593750.Metfor_0086; -.
DR GeneID; 14308759; -.
DR KEGG; mfo:Metfor_0086; -.
DR eggNOG; arCOG01529; Archaea.
DR HOGENOM; CLU_000022_3_6_2; -.
DR InParanoid; L0H8X7; -.
DR OrthoDB; 371752at2157; -.
DR Proteomes; UP000010824; Chromosome.
DR GO; GO:0003987; F:acetate-CoA ligase activity; IEA:InterPro.
DR GO; GO:0016208; F:AMP binding; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0019427; P:acetyl-CoA biosynthetic process from acetate; IEA:InterPro.
DR CDD; cd05966; ACS; 1.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR InterPro; IPR011904; Ac_CoA_lig.
DR InterPro; IPR032387; ACAS_N.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR NCBIfam; TIGR02188; Ac_CoA_lig_AcsA; 1.
DR PANTHER; PTHR24095; ACETYL-COENZYME A SYNTHETASE; 1.
DR PANTHER; PTHR24095:SF14; ACETYL-COENZYME A SYNTHETASE 1; 1.
DR Pfam; PF16177; ACAS_N; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF13193; AMP-binding_C; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000313|EMBL:AGB01172.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000010824}.
FT DOMAIN 31..84
FT /note="Acetyl-coenzyme A synthetase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16177"
FT DOMAIN 87..469
FT /note="AMP-dependent synthetase/ligase"
FT /evidence="ECO:0000259|Pfam:PF00501"
FT DOMAIN 529..607
FT /note="AMP-binding enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13193"
SQ SEQUENCE 630 AA; 70789 MW; E565E90C4B816A95 CRC64;
MTEDFDVRLV EDVKSYTPDP QYRKNAWMGD YQKVYNEFLA DPDAFWEKMA KELDWIKPWN
KVKEWNYPYA KWFTGARLNV SANCLDRHVN NSRRNKVALI WKGEEGRERI FTYQKLLSQV
ARFANALKKI GVKKGDTVCI YMPLVPEQVI AMLACARIGA VHSVVFGGFG AAALNMRIKD
ADAKVVITAD ITIRRGKAIQ LKAIVDEAII NAPTVENVIV LRRREPPVDL HEKELDFYEM
MNGMPDVCPP EVMDAEDPFF ILYTSGSTGK PKGIVHTCGG YMVGTYYTSK YIFDIKDNDT
YWCTADPGWI TGHSYIVYGP LAVGATVFIT ELTPDYPDAG SFWNLIEEQK ITIFYTAPTA
IRMFMKMGES WPDKYDLSSL RIIGSVGEPL NPEAFEWYYR VIGKSKTPIL DTWWQTETGM
HMITTMIGET MHPGFAGKPI PGIEADVVDK DGTSVKPGTG GLLVIKSPWP SMLRTVYKDD
ERYRKYWETI PGVYTVGDLA VKGKDGYIMI LGRSDDIIIV AGHNIGTAEV ESALVSHHAV
AEAAVIGKPD VVKGNSIKAF VILRVGNLPS DRLKQDLLHH VRTTLGPIAM PHEIDFVDKL
PKTRSGKIMR RVLKAKEMGM DPGDISTLEE
//
