ID L0HD91_METFS Unreviewed; 266 AA.
AC L0HD91;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=formylmethanofuran dehydrogenase {ECO:0000256|ARBA:ARBA00012692};
DE EC=1.2.7.12 {ECO:0000256|ARBA:ARBA00012692};
GN OrderedLocusNames=Metfor_0686 {ECO:0000313|EMBL:AGB01746.1};
OS Methanoregula formicica (strain DSM 22288 / NBRC 105244 / SMSP).
OC Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC Methanomicrobiales; Methanoregulaceae; Methanoregula.
OX NCBI_TaxID=593750 {ECO:0000313|EMBL:AGB01746.1, ECO:0000313|Proteomes:UP000010824};
RN [1] {ECO:0000313|Proteomes:UP000010824}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 22288 / NBRC 105244 / SMSP
RC {ECO:0000313|Proteomes:UP000010824};
RA Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA Peters L., Ovchinnikova G., Teshima H., Detter J.C., Han C., Tapia R.,
RA Land M., Hauser L., Kyrpides N., Ivanova N., Pagani I., Imachi H.,
RA Tamaki H., Sekiguchi Y., Kamagata Y., Cadillo-Quiroz H., Zinder S.,
RA Liu W.-T., Woyke T.;
RT "Complete sequence of Methanoregula formicicum SMSP.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AGB01746.1, ECO:0000313|Proteomes:UP000010824}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 22288 / NBRC 105244 / SMSP
RC {ECO:0000313|Proteomes:UP000010824};
RX PubMed=25189582;
RA Yamamoto K., Tamaki H., Cadillo-Quiroz H., Imachi H., Kyrpides N.,
RA Woyke T., Goodwin L., Zinder S.H., Kamagata Y., Liu W.T.;
RT "Complete Genome Sequence of Methanoregula formicica SMSPT, a Mesophilic
RT Hydrogenotrophic Methanogen Isolated from a Methanogenic Upflow Anaerobic
RT Sludge Blanket Reactor.";
RL Genome Announc. 2:e00870-14(2014).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + N-formylmethanofuran + 2 oxidized [2Fe-2S]-[ferredoxin]
CC = CO2 + H(+) + methanofuran + 2 reduced [2Fe-2S]-[ferredoxin];
CC Xref=Rhea:RHEA:19841, Rhea:RHEA-COMP:10000, Rhea:RHEA-COMP:10001,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526,
CC ChEBI:CHEBI:33737, ChEBI:CHEBI:33738, ChEBI:CHEBI:57727,
CC ChEBI:CHEBI:58151; EC=1.2.7.12;
CC Evidence={ECO:0000256|ARBA:ARBA00000989};
CC -!- PATHWAY: One-carbon metabolism; methanogenesis from CO(2); 5,10-
CC methenyl-5,6,7,8-tetrahydromethanopterin from CO(2): step 1/3.
CC {ECO:0000256|ARBA:ARBA00004830}.
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DR EMBL; CP003167; AGB01746.1; -; Genomic_DNA.
DR RefSeq; WP_015284710.1; NC_019943.1.
DR AlphaFoldDB; L0HD91; -.
DR STRING; 593750.Metfor_0686; -.
DR GeneID; 14309999; -.
DR KEGG; mfo:Metfor_0686; -.
DR eggNOG; arCOG00097; Archaea.
DR HOGENOM; CLU_072248_0_0_2; -.
DR InParanoid; L0HD91; -.
DR OrthoDB; 106216at2157; -.
DR UniPathway; UPA00640; UER00692.
DR Proteomes; UP000010824; Chromosome.
DR GO; GO:0018493; F:formylmethanofuran dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0046914; F:transition metal ion binding; IEA:InterPro.
DR GO; GO:0019386; P:methanogenesis, from carbon dioxide; IEA:UniProtKB-UniPathway.
DR Gene3D; 2.160.20.60; Glutamate synthase, alpha subunit, C-terminal domain; 1.
DR InterPro; IPR017550; Formylmethanofuran_DH_suC.
DR InterPro; IPR036485; Glu_synth_asu_C_sf.
DR NCBIfam; TIGR03122; one_C_dehyd_C; 1.
DR PANTHER; PTHR39673; TUNGSTEN FORMYLMETHANOFURAN DEHYDROGENASE, SUBUNIT C (FWDC); 1.
DR PANTHER; PTHR39673:SF7; TUNGSTEN-CONTAINING FORMYLMETHANOFURAN DEHYDROGENASE 2 SUBUNIT C; 1.
DR SUPFAM; SSF69336; Alpha subunit of glutamate synthase, C-terminal domain; 1.
PE 4: Predicted;
KW Methanogenesis {ECO:0000256|ARBA:ARBA00022994};
KW Reference proteome {ECO:0000313|Proteomes:UP000010824};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
SQ SEQUENCE 266 AA; 27729 MW; 2342E1BD296DC18C CRC64;
METVTITMKN APALYLEADT ISPDAFAGKS AAQIAELPVF EGNVPSTLGK YFEVSGNAGA
TAADTKIVVK GDAKKVKYIG FKMTAGEVVI EGPADQYVGA WMKGGNLTAK GDVGAFAATA
MKGGEMVIEG NAGNYLGAAY RGDWRGMSGG KILVKGNAGS DTGMYMLGGE ITINGNCDVH
IMTHAEGGKV TIKGNAASKL GGQMVEGTII VFGNIDVMMP GFKPNGEVEL EVDGTKAKFA
HFIGDMGERH KKKKGVVVYG NLYKKI
//
