ID L0HDL5_METFS Unreviewed; 374 AA.
AC L0HDL5;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 24-JAN-2024, entry version 35.
DE SubName: Full=TIR domain-containing protein {ECO:0000313|EMBL:AGB01418.1};
GN OrderedLocusNames=Metfor_0341 {ECO:0000313|EMBL:AGB01418.1};
OS Methanoregula formicica (strain DSM 22288 / NBRC 105244 / SMSP).
OC Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC Methanomicrobiales; Methanoregulaceae; Methanoregula.
OX NCBI_TaxID=593750 {ECO:0000313|EMBL:AGB01418.1, ECO:0000313|Proteomes:UP000010824};
RN [1] {ECO:0000313|Proteomes:UP000010824}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 22288 / NBRC 105244 / SMSP
RC {ECO:0000313|Proteomes:UP000010824};
RA Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA Peters L., Ovchinnikova G., Teshima H., Detter J.C., Han C., Tapia R.,
RA Land M., Hauser L., Kyrpides N., Ivanova N., Pagani I., Imachi H.,
RA Tamaki H., Sekiguchi Y., Kamagata Y., Cadillo-Quiroz H., Zinder S.,
RA Liu W.-T., Woyke T.;
RT "Complete sequence of Methanoregula formicicum SMSP.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AGB01418.1, ECO:0000313|Proteomes:UP000010824}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 22288 / NBRC 105244 / SMSP
RC {ECO:0000313|Proteomes:UP000010824};
RX PubMed=25189582;
RA Yamamoto K., Tamaki H., Cadillo-Quiroz H., Imachi H., Kyrpides N.,
RA Woyke T., Goodwin L., Zinder S.H., Kamagata Y., Liu W.T.;
RT "Complete Genome Sequence of Methanoregula formicica SMSPT, a Mesophilic
RT Hydrogenotrophic Methanogen Isolated from a Methanogenic Upflow Anaerobic
RT Sludge Blanket Reactor.";
RL Genome Announc. 2:e00870-14(2014).
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DR EMBL; CP003167; AGB01418.1; -; Genomic_DNA.
DR RefSeq; WP_015284382.1; NC_019943.1.
DR AlphaFoldDB; L0HDL5; -.
DR STRING; 593750.Metfor_0341; -.
DR GeneID; 25397768; -.
DR KEGG; mfo:Metfor_0341; -.
DR eggNOG; arCOG03732; Archaea.
DR eggNOG; arCOG07676; Archaea.
DR eggNOG; arCOG09612; Archaea.
DR HOGENOM; CLU_738907_0_0_2; -.
DR InParanoid; L0HDL5; -.
DR OrthoDB; 118149at2157; -.
DR Proteomes; UP000010824; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR Pfam; PF13676; TIR_2; 1.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS50104; TIR; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000010824};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 213..236
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 11..139
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
FT REGION 170..203
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 374 AA; 40407 MW; 01F072701D3A59BB CRC64;
MTDDPLQKSS GHHDVFISYA QEDKIIADAV CARLESRNIR CWIAPRDINP GKNFPEAIIE
GIEEGKVLVV IFSSSANKSP HVTRELTHAV NKGRIIIPFR IEDVTPSKSM EYLIGVPHWL
DAVTPPMEQH IDRLVGTVEH IIGKRTVTAV PPIPAEAAAS PPVPKLVPQE IPDESSPGQM
PETTPVIPTP KEEAKEAAGS RPSSGVPVWN TKVLAAAGIG LVVVILLSVM MLTGIFNPPT
GLNASGAAGT SSAIDYRSSD ALVNTVVLTV EPTQTLAKDT ELYIDANKDN SNAMVTVTFN
GGPGMGLIKD NRVILTRSDG TETGGKLNFN QRLSEVKLQG TRGTDRIRVI VTLYSGSEKT
IVDKLLYYRT YRSM
//
