ID   L0HF41_METFS            Unreviewed;       872 AA.
AC   L0HF41;
DT   06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT   06-MAR-2013, sequence version 1.
DT   27-MAR-2024, entry version 38.
DE   SubName: Full=Collagenase-like protease {ECO:0000313|EMBL:AGB02635.1};
DE   Flags: Precursor;
GN   OrderedLocusNames=Metfor_1605 {ECO:0000313|EMBL:AGB02635.1};
OS   Methanoregula formicica (strain DSM 22288 / NBRC 105244 / SMSP).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC   Methanomicrobiales; Methanoregulaceae; Methanoregula.
OX   NCBI_TaxID=593750 {ECO:0000313|EMBL:AGB02635.1, ECO:0000313|Proteomes:UP000010824};
RN   [1] {ECO:0000313|Proteomes:UP000010824}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 22288 / NBRC 105244 / SMSP
RC   {ECO:0000313|Proteomes:UP000010824};
RA   Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA   Peters L., Ovchinnikova G., Teshima H., Detter J.C., Han C., Tapia R.,
RA   Land M., Hauser L., Kyrpides N., Ivanova N., Pagani I., Imachi H.,
RA   Tamaki H., Sekiguchi Y., Kamagata Y., Cadillo-Quiroz H., Zinder S.,
RA   Liu W.-T., Woyke T.;
RT   "Complete sequence of Methanoregula formicicum SMSP.";
RL   Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:AGB02635.1, ECO:0000313|Proteomes:UP000010824}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 22288 / NBRC 105244 / SMSP
RC   {ECO:0000313|Proteomes:UP000010824};
RX   PubMed=25189582;
RA   Yamamoto K., Tamaki H., Cadillo-Quiroz H., Imachi H., Kyrpides N.,
RA   Woyke T., Goodwin L., Zinder S.H., Kamagata Y., Liu W.T.;
RT   "Complete Genome Sequence of Methanoregula formicica SMSPT, a Mesophilic
RT   Hydrogenotrophic Methanogen Isolated from a Methanogenic Upflow Anaerobic
RT   Sludge Blanket Reactor.";
RL   Genome Announc. 2:e00870-14(2014).
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DR   EMBL; CP003167; AGB02635.1; -; Genomic_DNA.
DR   RefSeq; WP_015285598.1; NC_019943.1.
DR   AlphaFoldDB; L0HF41; -.
DR   STRING; 593750.Metfor_1605; -.
DR   GeneID; 14307994; -.
DR   KEGG; mfo:Metfor_1605; -.
DR   eggNOG; arCOG03203; Archaea.
DR   HOGENOM; CLU_011540_4_0_2; -.
DR   InParanoid; L0HF41; -.
DR   OrthoDB; 51464at2157; -.
DR   Proteomes; UP000010824; Chromosome.
DR   GO; GO:0008233; F:peptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0044249; P:cellular biosynthetic process; IEA:UniProt.
DR   GO; GO:1901576; P:organic substance biosynthetic process; IEA:UniProt.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   InterPro; IPR020988; Pept_U32_collagenase.
DR   InterPro; IPR001539; Peptidase_U32.
DR   PANTHER; PTHR30217:SF10; 23S RRNA 5-HYDROXYCYTIDINE C2501 SYNTHASE; 1.
DR   PANTHER; PTHR30217; PEPTIDASE U32 FAMILY; 1.
DR   Pfam; PF12392; DUF3656; 1.
DR   Pfam; PF01136; Peptidase_U32; 2.
DR   PROSITE; PS01276; PEPTIDASE_U32; 1.
PE   4: Predicted;
KW   Hydrolase {ECO:0000313|EMBL:AGB02635.1};
KW   Protease {ECO:0000313|EMBL:AGB02635.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000010824}.
FT   DOMAIN          402..523
FT                   /note="Peptidase U32 collagenase"
FT                   /evidence="ECO:0000259|Pfam:PF12392"
SQ   SEQUENCE   872 AA;  94870 MW;  6D08E523C641D519 CRC64;
     MNPRARTLPE LLAPAGSPEA LRAAIAAGAD AVYLSGKRFG ARKYAANFSD KEIEEAVRYA
     HSYGICVYVT VNTLIHDREL DGVLEYLSWL WSIGVDAVLV QDAGLAALAR EFLPGLTLHA
     STQMTIHNSD GVRWAAEQGL SRVVLARELS LYEVEQIAEE TRDTGTGLEV FAHGALCYGY
     SGQCLLSSVI GGRSGNRGMC AQPCRKPYAL VQGETDAYGR PENLKEVAQK EKYLLSPKDL
     CTYNHLPELV KSPVASLKIE GRMKSPEYVA MVVSTYRRAL DAIAAGTWEP SREDYRDLLM
     AFNREFTDGY LFGDRYGKLM GRDAPDNRGL AVGRVERYDR KSKTAFVRPS CLVTPVPGDG
     LLITLPGEAG RDLGFALNAA AKPSPRGYLL PVPAPVPEGA LVYITSSPGF DARARRIIAK
     PPADLLRPLP ADMEITISSS GSVAIDGPVT RPDGTTIPVS YQPDRALEPA TTRPLTAGQL
     EEQFRKTGGT PFVVGECTIH YDGGLFAPMA LLNDMRREFF RRAGELLDAS YRPSPEDIGK
     ARKALQARVS GRSPHTRRGG RNGADRLRLA VITDIPDQVR GARDGGADTI LFEPAVPSER
     HTCAGRVPDG FLRMQIREAM DACRNTRARF VLKLPRILHD GELEKILAEI TEAEREGLAF
     CMSENPGISH TVARTIPGMA LLGGAGLNIF NHAAATRSAP RYRLLTLSSE LSRNEIAELI
     ASSVGSGDVP DFALIVQGSS EALVTEDCIP RLVRQCRGDK GRIFALRDDT GRVFPLHEAA
     DCRTRIANAA ELCLIDMLKE IRDAGIAEII VDARFRPPAY TAAMTRLYRE AVDALGEPGA
     PRDVKLRDLK ERAKALSLGG ITAGHFIRGL KE
//