ID L0IHD2_HALRX Unreviewed; 378 AA.
AC L0IHD2;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE RecName: Full=Probable porphobilinogen deaminase {ECO:0000256|ARBA:ARBA00021723};
DE EC=2.5.1.61 {ECO:0000256|ARBA:ARBA00012655};
GN OrderedLocusNames=Halru_3085 {ECO:0000313|EMBL:AGB17651.1};
OS Halovivax ruber (strain DSM 18193 / JCM 13892 / XH-70).
OC Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Natrialbales;
OC Natrialbaceae; Halovivax.
OX NCBI_TaxID=797302 {ECO:0000313|EMBL:AGB17651.1, ECO:0000313|Proteomes:UP000010846};
RN [1] {ECO:0000313|Proteomes:UP000010846}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 18193 / JCM 13892 / XH-70
RC {ECO:0000313|Proteomes:UP000010846};
RA Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA Peters L., Mikhailova N., Davenport K., Detter J.C., Han C., Tapia R.,
RA Land M., Hauser L., Kyrpides N., Ivanova N., Pagani I., Sproer C.,
RA Anderson I., Woyke T.;
RT "Complete sequence of Halovivax ruber XH-70.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=dipyrromethane; Xref=ChEBI:CHEBI:60342;
CC Evidence={ECO:0000256|ARBA:ARBA00001916};
CC -!- SIMILARITY: Belongs to the HMBS family.
CC {ECO:0000256|ARBA:ARBA00005638}.
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DR EMBL; CP003050; AGB17651.1; -; Genomic_DNA.
DR AlphaFoldDB; L0IHD2; -.
DR STRING; 797302.Halru_3085; -.
DR KEGG; hru:Halru_3085; -.
DR eggNOG; arCOG04299; Archaea.
DR HOGENOM; CLU_019704_1_0_2; -.
DR OrthoDB; 8042at2157; -.
DR Proteomes; UP000010846; Chromosome.
DR GO; GO:0004418; F:hydroxymethylbilane synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0006779; P:porphyrin-containing compound biosynthetic process; IEA:UniProtKB-KW.
DR Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 4.
DR Gene3D; 3.30.160.40; Porphobilinogen deaminase, C-terminal domain; 1.
DR InterPro; IPR000860; HemC.
DR InterPro; IPR022419; Porphobilin_deaminase_cofac_BS.
DR InterPro; IPR022417; Porphobilin_deaminase_N.
DR InterPro; IPR022418; Porphobilinogen_deaminase_C.
DR InterPro; IPR036803; Porphobilinogen_deaminase_C_sf.
DR NCBIfam; TIGR00212; hemC; 1.
DR PANTHER; PTHR11557; PORPHOBILINOGEN DEAMINASE; 1.
DR PANTHER; PTHR11557:SF0; PORPHOBILINOGEN DEAMINASE; 1.
DR Pfam; PF01379; Porphobil_deam; 2.
DR Pfam; PF03900; Porphobil_deamC; 1.
DR PRINTS; PR00151; PORPHBDMNASE.
DR SUPFAM; SSF53850; Periplasmic binding protein-like II; 2.
DR SUPFAM; SSF54782; Porphobilinogen deaminase (hydroxymethylbilane synthase), C-terminal domain; 1.
DR PROSITE; PS00533; PORPHOBILINOGEN_DEAM; 1.
PE 3: Inferred from homology;
KW Porphyrin biosynthesis {ECO:0000256|ARBA:ARBA00023244};
KW Reference proteome {ECO:0000313|Proteomes:UP000010846};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 7..162
FT /note="Porphobilinogen deaminase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF01379"
FT DOMAIN 214..263
FT /note="Porphobilinogen deaminase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF01379"
FT DOMAIN 280..335
FT /note="Porphobilinogen deaminase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03900"
FT REGION 162..187
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 356..378
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 378 AA; 41262 MW; 2005BE4041BC9B4D CRC64;
MKSRGTLRLA TRGSLLARRQ AGMVGERLEE RRYDVDLVTV ETTGDQLADE LIHRLGKTGA
FVRELDERVL DGDCDAAIHS LKDVPTEQPD ELVTAAVPER GPAEDVLLTP EGTTLDDLPR
GATVGTSSLR RRALLLDQRP DLTVEPLRGN VDTRIEKLLA PTLQAEHEAR TEADKERKGH
AGDEDFEPEY DRTVEEWFDD RSELEKGALG REVETEYDAI VLARAGLERS GLAHAVDFEP
LSLTTFVPSP GQGALCVTAT DGETAREIQS AIDHPRSRVE VTVERTILAT LGGGCIAPLG
IHAVVQGEYV HTAVAVYDRD GETSVKATRD LPIETHATAA REFADELADR GAAELIEESR
KELEDDGEPA PEDQPEGK
//
