ID L0INU8_9MYCO Unreviewed; 416 AA.
AC L0INU8;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE SubName: Full=3-oxoacyl-(Acyl-carrier-protein) synthase {ECO:0000313|EMBL:AGB21175.1};
GN ORFNames=Mycsm_00734 {ECO:0000313|EMBL:AGB21175.1};
OS Mycobacterium sp. JS623.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium.
OX NCBI_TaxID=212767 {ECO:0000313|EMBL:AGB21175.1, ECO:0000313|Proteomes:UP000010844};
RN [1] {ECO:0000313|Proteomes:UP000010844}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JS623 {ECO:0000313|Proteomes:UP000010844};
RG US DOE Joint Genome Institute;
RA Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA Peters L., Teshima H., Detter J.C., Han C., Tapia R., Land M., Hauser L.,
RA Kyrpides N., Ivanova N., Pagani I., Mattes T., Holmes A., Rutledge P.,
RA Paulsen I., Coleman N., Woyke T.;
RT "Complete sequence of chromosome of Mycobacterium smegmatis JS623.";
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Lipid metabolism; mycolic acid biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004796}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP
CC synthases family. {ECO:0000256|ARBA:ARBA00008467,
CC ECO:0000256|RuleBase:RU003694}.
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DR EMBL; CP003078; AGB21175.1; -; Genomic_DNA.
DR RefSeq; WP_015304765.1; NC_019966.1.
DR AlphaFoldDB; L0INU8; -.
DR STRING; 212767.Mycsm_00734; -.
DR KEGG; msa:Mycsm_00734; -.
DR PATRIC; fig|710686.3.peg.736; -.
DR HOGENOM; CLU_000022_69_2_11; -.
DR OrthoDB; 9808669at2; -.
DR UniPathway; UPA00915; -.
DR Proteomes; UP000010844; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016747; F:acyltransferase activity, transferring groups other than amino-acyl groups; IEA:UniProt.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:UniProt.
DR CDD; cd00834; KAS_I_II; 1.
DR Gene3D; 3.40.47.10; -; 2.
DR InterPro; IPR000794; Beta-ketoacyl_synthase.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR11712:SF336; 3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11712; POLYKETIDE SYNTHASE-RELATED; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SUPFAM; SSF53901; Thiolase-like; 2.
DR PROSITE; PS52004; KS3_2; 1.
PE 3: Inferred from homology;
KW Lipid biosynthesis {ECO:0000256|ARBA:ARBA00022516};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00022516};
KW Transferase {ECO:0000256|RuleBase:RU003694}.
FT DOMAIN 10..415
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
SQ SEQUENCE 416 AA; 43555 MW; 4954736BC21739EA CRC64;
MASLRTGDGF PDVVVTAVAS TTSLAPDAEK TWQALLEGQS GVRELDKPFI TDFDSPVRIG
APLQENFDAH LSRVELRRLA YMQKMSLVLG RRLWENAGTP DVDTRRLMIS MGLALGSTEE
IPVQYDSWKE KGLRAVSPLA VQMYMPNSPA AALGLDRQAK AGIMSPIMAD ASGAAAVAEA
WRQIVLGEAD IAICGGVETH VEAVPVASFW QAGLLSTNND DPQGACRPFD KDRDGMVLGE
GGALLLIETE DHAKARGAPI LARVMGAAMT SDGYDVVEPD PSGEEAATAI VRAVELAGLT
PTDIDHVNAH ATGTKLGDLA EAKAIAAVFG NHRPAVFAPK AALGHSLGAA GAVEAVLTVQ
ALRDGVVPPT LNLKDLDPEI ELDVVSGSPR TGDYRYAVTN SFGIGGTNVA VVFGAS
//
