ID   L0IUX7_9MYCO            Unreviewed;       836 AA.
AC   L0IUX7;
DT   06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT   06-MAR-2013, sequence version 1.
DT   24-JAN-2024, entry version 52.
DE   SubName: Full=Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II {ECO:0000313|EMBL:AGB22684.1};
GN   ORFNames=Mycsm_02341 {ECO:0000313|EMBL:AGB22684.1};
OS   Mycobacterium sp. JS623.
OC   Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC   Mycobacterium.
OX   NCBI_TaxID=212767 {ECO:0000313|EMBL:AGB22684.1, ECO:0000313|Proteomes:UP000010844};
RN   [1] {ECO:0000313|Proteomes:UP000010844}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JS623 {ECO:0000313|Proteomes:UP000010844};
RG   US DOE Joint Genome Institute;
RA   Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA   Peters L., Teshima H., Detter J.C., Han C., Tapia R., Land M., Hauser L.,
RA   Kyrpides N., Ivanova N., Pagani I., Mattes T., Holmes A., Rutledge P.,
RA   Paulsen I., Coleman N., Woyke T.;
RT   "Complete sequence of chromosome of Mycobacterium smegmatis JS623.";
RL   Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; CP003078; AGB22684.1; -; Genomic_DNA.
DR   RefSeq; WP_015306264.1; NC_019966.1.
DR   AlphaFoldDB; L0IUX7; -.
DR   STRING; 212767.Mycsm_02341; -.
DR   KEGG; msa:Mycsm_02341; -.
DR   PATRIC; fig|710686.3.peg.2360; -.
DR   HOGENOM; CLU_337954_0_0_11; -.
DR   OrthoDB; 8445630at2; -.
DR   Proteomes; UP000010844; Chromosome.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR   GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR   Gene3D; 1.10.1200.10; ACP-like; 1.
DR   Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR   InterPro; IPR036736; ACP-like_sf.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR   InterPro; IPR042099; ANL_N_sf.
DR   InterPro; IPR020806; PKS_PP-bd.
DR   InterPro; IPR009081; PP-bd_ACP.
DR   PANTHER; PTHR43767; LONG-CHAIN-FATTY-ACID--COA LIGASE; 1.
DR   PANTHER; PTHR43767:SF1; NONRIBOSOMAL PEPTIDE SYNTHASE PES1 (EUROFUNG)-RELATED; 1.
DR   Pfam; PF00501; AMP-binding; 1.
DR   Pfam; PF00550; PP-binding; 1.
DR   SMART; SM00823; PKS_PP; 1.
DR   SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR   SUPFAM; SSF47336; ACP-like; 1.
PE   4: Predicted;
KW   Ligase {ECO:0000313|EMBL:AGB22684.1}; Membrane {ECO:0000256|SAM:Phobius};
KW   Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        540..558
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        579..597
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        623..642
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        654..674
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        680..696
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        726..742
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        770..791
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          444..499
FT                   /note="Polyketide synthase phosphopantetheine-binding"
FT                   /evidence="ECO:0000259|SMART:SM00823"
SQ   SEQUENCE   836 AA;  91693 MW;  D04430EF62193765 CRC64;
     MNRLLEHLRA HGEKVAILTE TEQLTYHQLT DRVADTAREL RGRRRLVLLE THNEVTTLVH
     YLGAMAAGHV VLPASAGHDH AAIMQTYEPD VVIDADGIHR RGQHHRLHDE LALLLSTSGS
     TGSPKLVRLS YRNLCSNAEA IADYLDIRET DRAATTLRMS YCYGLSVIHS HLLRGAGLIV
     TDRSVVDEEF WGLFRRHRGT AFAGVPYTFE LLERMDAQTL DLPHLRYLTQ AGGRMPPERV
     RQFAELGQQQ GWDLFVMYGA TEATARMAYL SPQLASSHPA AIGRPIPGGA FSIEPSGELV
     YRGPNVMMGY AHGPDDLALG KTVEALHTGD IARRGPEGLY EVIGRSSRFV KMYGLRIDLQ
     RVEATLSDHG VTAFCTDVDD RLAVGAAVDD PGEVRRIAAG AAGIPATAVL VVTLADLPLL
     PSGKPDYQVI RKLARASNTN EPSVIGLRKL YGDVLGLDAD SIDPDTSFVD LGGNSLTYVT
     MSVRLERALG RLPADWQRLP LRELERMPEP RRRRWGATLE TTVALRAAAI LLIVGSHAGL
     FELWGGAHLL LGVAGYNFGR FCLTPVPRTD RVRHLRNTIA WIAGPSVAWA AIALLITDDY
     APTNLLLAHK FLGPHDSMTA GRLWFVEVLV WILVALALLC WLPALDRWER QWPFTVAIAF
     LAVGLALRYD ILGLHLGRDA WFTMLAFWFF AVGWAAAKAS TTLQRAAVTV VLIIGLHGYF
     DRAERELLVL AGFALLIWLP ALRCPPAATV VAGVIAEASL YIYLTHFQVY PLFGGHPLLG
     VVGAVIVGVL LTRLVSVLRR RLALGDKAFL RQGRRDETVG ADQAGGHDTT PAGRRG
//