ID L0JKJ1_NATP1 Unreviewed; 828 AA.
AC L0JKJ1;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=Putative lipid/cholesterol transport {ECO:0000313|EMBL:ELY81246.1};
DE SubName: Full=RND superfamily exporter {ECO:0000313|EMBL:AGB31102.1};
GN OrderedLocusNames=Natpe_1196 {ECO:0000313|EMBL:AGB31102.1};
GN ORFNames=C488_01959 {ECO:0000313|EMBL:ELY81246.1};
OS Natrinema pellirubrum (strain DSM 15624 / CIP 106293 / JCM 10476 / NCIMB
OS 786 / 157).
OC Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Natrialbales;
OC Natrialbaceae; Natrinema.
OX NCBI_TaxID=797303 {ECO:0000313|EMBL:AGB31102.1, ECO:0000313|Proteomes:UP000010843};
RN [1] {ECO:0000313|EMBL:AGB31102.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=DSM 15624 {ECO:0000313|EMBL:AGB31102.1};
RG US DOE Joint Genome Institute;
RA Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA Peters L., Teshima H., Detter J.C., Han C., Tapia R., Land M., Hauser L.,
RA Kyrpides N., Ivanova N., Pagani I., Sproer C., Anderson I., Woyke T.;
RT "Complete sequence of chromosome of Natrinema pellirubrum DSM 15624.";
RL Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000010843}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 15624 / JCM 10476 / NCIMB 786
RC {ECO:0000313|Proteomes:UP000010843};
RA Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA Peters L., Teshima H., Detter J.C., Han C., Tapia R., Land M., Hauser L.,
RA Kyrpides N., Ivanova N., Pagani I., Sproer C., Anderson I., Woyke T.;
RT "Complete sequence of chromosome of Natrinema pellirubrum DSM 15624.";
RL Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Proteomes:UP000011593}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 15624 {ECO:0000313|Proteomes:UP000011593};
RA Becker E.A., Seitzer P., Tritt A., Larsen D., Yao A., Wu D., Darling A.,
RA Eisen J.A., Facciotti M.T.;
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:ELY81246.1, ECO:0000313|Proteomes:UP000011593}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 15624 {ECO:0000313|EMBL:ELY81246.1,
RC ECO:0000313|Proteomes:UP000011593};
RX PubMed=25393412; DOI=10.1371/journal.pgen.1004784;
RA Becker E.A., Seitzer P.M., Tritt A., Larsen D., Krusor M., Yao A.I., Wu D.,
RA Madern D., Eisen J.A., Darling A.E., Facciotti M.T.;
RT "Phylogenetically driven sequencing of extremely halophilic archaea reveals
RT strategies for static and dynamic osmo-response.";
RL PLoS Genet. 10:E1004784-E1004784(2014).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; CP003372; AGB31102.1; -; Genomic_DNA.
DR EMBL; AOIE01000006; ELY81246.1; -; Genomic_DNA.
DR RefSeq; WP_006179703.1; NZ_AOIE01000006.1.
DR AlphaFoldDB; L0JKJ1; -.
DR STRING; 797303.Natpe_1196; -.
DR GeneID; 14334359; -.
DR KEGG; npe:Natpe_1196; -.
DR PATRIC; fig|797303.5.peg.408; -.
DR eggNOG; arCOG02174; Archaea.
DR HOGENOM; CLU_003088_0_0_2; -.
DR OrthoDB; 42357at2157; -.
DR Proteomes; UP000010843; Chromosome.
DR Proteomes; UP000011593; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR004869; MMPL_dom.
DR InterPro; IPR000731; SSD.
DR PANTHER; PTHR33406; MEMBRANE PROTEIN MJ1562-RELATED; 1.
DR PANTHER; PTHR33406:SF2; MEMBRANE PROTEIN SCO6666-RELATED; 1.
DR Pfam; PF03176; MMPL; 2.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR PROSITE; PS50156; SSD; 2.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 24..43
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 238..255
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 262..284
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 290..312
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 333..352
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 364..384
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 428..447
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 654..673
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 680..701
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 707..725
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 755..775
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 781..808
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 264..383
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
FT DOMAIN 676..806
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
SQ SEQUENCE 828 AA; 88704 MW; 1A2733A0A98F7232 CRC64;
MTAGERIETA TETLNDVIIA RSRTVVIGFL VLTVVFAGGF GLVTTDTDST DSFTEDLPEQ
DALDSVNEEF EGPFQTSDET TQLVHTGDNV LTKEGLIRSL LVLERVEQRE DLRMESANGP
APLIAQAIDP TATTPAEQRQ VIESATTTEI RQAIREQSDD PTFKRTLSTD FNPTAASASA
SITVISHDIP NEFTDDDLTD IQLSIKSIAS DQTGDIRAFG SGITDAETAN VIGDSMTLVM
PVVVLLLLAF LAISYRDPID LALGLLALLM TVIWTFGFLG YSGIPFNQQM VSVPVLLLAV
GVDFGIHIVN RYREETVQGY EPLEAMRTAN NQLMVAFVIV TVTTVFGFGA NVISDLGPIR
NMGIASSVGI IFTFFIFGIF LPAAKLEVDQ LRERFGIPEF GSDPIASEDS SLGRLLAMPA
KASRHAPLVF VIVLIVIGGA AAGYGAGVDT SFDTEDFLPP EEQPAYVSYV PAPLAPNEYT
VTETINLLED KFATDQDESV KIYVEGSFED DHALEALADP NDDPPSNLAV GSGGEAEARS
IITVIQAHAA EDPEFAALVD RNDRNDNDIP DRNLDLIYDE LFASSAGSQA EQYLTEDRRK
AQVEYAIDGD ASQQAVAADA AEFATDFRYE ATATGNIVVF AAVTDLIFSS SVQGLILAIG
LTAVFLVITY AALERKPLLG IVNVFPILIA IALLIATMRL LGMSLNALTG TILSISVGLG
IAYSVHTTHR FVDELSETND AFTAITRTLS GTGGALMGSM LTTSLGTGAL ALAITPVLGD
FGLLMALSVA YSFVTSIVAL PPAMLLWARY NDSTSLWKRL VATSDVYE
//
