ID L0JL10_NATP1 Unreviewed; 488 AA.
AC L0JL10;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 27-MAR-2024, entry version 60.
DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN OrderedLocusNames=Natpe_2125 {ECO:0000313|EMBL:AGB31954.1};
GN ORFNames=C488_06270 {ECO:0000313|EMBL:ELY77880.1};
OS Natrinema pellirubrum (strain DSM 15624 / CIP 106293 / JCM 10476 / NCIMB
OS 786 / 157).
OC Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Natrialbales;
OC Natrialbaceae; Natrinema.
OX NCBI_TaxID=797303 {ECO:0000313|EMBL:AGB31954.1, ECO:0000313|Proteomes:UP000010843};
RN [1] {ECO:0000313|Proteomes:UP000010843}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 15624 / JCM 10476 / NCIMB 786
RC {ECO:0000313|Proteomes:UP000010843};
RA Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA Peters L., Teshima H., Detter J.C., Han C., Tapia R., Land M., Hauser L.,
RA Kyrpides N., Ivanova N., Pagani I., Sproer C., Anderson I., Woyke T.;
RT "Complete sequence of chromosome of Natrinema pellirubrum DSM 15624.";
RL Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AGB31954.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=DSM 15624 {ECO:0000313|EMBL:AGB31954.1};
RG US DOE Joint Genome Institute;
RA Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA Peters L., Teshima H., Detter J.C., Han C., Tapia R., Land M., Hauser L.,
RA Kyrpides N., Ivanova N., Pagani I., Sproer C., Anderson I., Woyke T.;
RT "Complete sequence of chromosome of Natrinema pellirubrum DSM 15624.";
RL Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Proteomes:UP000011593}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 15624 {ECO:0000313|Proteomes:UP000011593};
RA Becker E.A., Seitzer P., Tritt A., Larsen D., Yao A., Wu D., Darling A.,
RA Eisen J.A., Facciotti M.T.;
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:ELY77880.1, ECO:0000313|Proteomes:UP000011593}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 15624 {ECO:0000313|EMBL:ELY77880.1,
RC ECO:0000313|Proteomes:UP000011593};
RX PubMed=25393412; DOI=10.1371/journal.pgen.1004784;
RA Becker E.A., Seitzer P.M., Tritt A., Larsen D., Krusor M., Yao A.I., Wu D.,
RA Madern D., Eisen J.A., Darling A.E., Facciotti M.T.;
RT "Phylogenetically driven sequencing of extremely halophilic archaea reveals
RT strategies for static and dynamic osmo-response.";
RL PLoS Genet. 10:E1004784-E1004784(2014).
CC -!- SIMILARITY: Belongs to the helicase family. RAD25/XPB subfamily.
CC {ECO:0000256|ARBA:ARBA00006637}.
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DR EMBL; CP003372; AGB31954.1; -; Genomic_DNA.
DR EMBL; AOIE01000035; ELY77880.1; -; Genomic_DNA.
DR RefSeq; WP_006180594.1; NZ_AOIE01000035.1.
DR AlphaFoldDB; L0JL10; -.
DR STRING; 797303.Natpe_2125; -.
DR GeneID; 14335288; -.
DR KEGG; npe:Natpe_2125; -.
DR PATRIC; fig|797303.5.peg.1275; -.
DR eggNOG; arCOG00874; Archaea.
DR HOGENOM; CLU_008213_6_0_2; -.
DR OrthoDB; 11644at2157; -.
DR Proteomes; UP000010843; Chromosome.
DR Proteomes; UP000011593; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:InterPro.
DR CDD; cd17926; DEXHc_RE; 1.
DR CDD; cd18789; SF2_C_XPB; 1.
DR Gene3D; 3.40.1170.30; -; 1.
DR Gene3D; 6.10.140.1180; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR032438; ERCC3_RAD25_C.
DR InterPro; IPR006935; Helicase/UvrB_N.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR040699; XPB_DRD.
DR PANTHER; PTHR11274:SF0; GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPB; 1.
DR PANTHER; PTHR11274; RAD25/XP-B DNA REPAIR HELICASE; 1.
DR Pfam; PF16203; ERCC3_RAD25_C; 1.
DR Pfam; PF04851; ResIII; 1.
DR Pfam; PF18458; XPB_DRD; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000313|EMBL:AGB31954.1};
KW Helicase {ECO:0000313|EMBL:AGB31954.1};
KW Hydrolase {ECO:0000313|EMBL:AGB31954.1};
KW Nucleotide-binding {ECO:0000313|EMBL:AGB31954.1}.
FT DOMAIN 124..268
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 358..488
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
SQ SEQUENCE 488 AA; 54218 MW; F7E2CCAF95C88496 CRC64;
MCIYPRLGRV TRSPNDEPTS IECRYEDGTV RIDGLETAPL SPSSLRESVP ELEADSRTGC
WRVPAYRYAE LRAALWRADA AVEDRVLDLE SVASLTSAYE LRPYQERALE AWLGTDRWAD
APGPESPARA PAGVLELPTG SGKTVIALKA IERLSVPTLI VVPTIDLLEQ WERELKREFD
TPIGRFGGGE QRLEPITVST YDSAYLKADS VGDRFGFAVF DEAHHLGGEG YREIARLLAA
PARVGLTATF ERPDGAHEVV EALVGPLVHQ VGVDDLAGDH LAAYDLKRLK VSLTPEEREE
YERNQETFTG YLARSNIEMR SGSDYQELVK RSGSDPEARE ALLARQRARE IMFGSEAKLE
ALSGILDDHR DDRVIVFTAH NDLAYDVSER FLIPTITHRT GTAERREILE RFRDGSYTRI
ATSNVLDEGV DVPDANVAVV LSGSGSEREF VQRLGRILRP KADGGRAVLY EVITADTGEQ
RIAARRRE
//
