UniProt: L0JQX6

Database: UniProt
Entry: L0JQX6_NATP1

LinkDB:  L0JQX6_NATP1 
Original site:  L0JQX6_NATP1

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Ontology (4)   
   GO (4)   
Gene (2)   
   KEGG GENES (1)   
   NCBI-Gene (1)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (2)   
   EMBL (2)   
Protein domain (10)   
   InterPro (6)   
   Pfam (2)   
   SMART (2)   
Literature (1)   
   PubMed (1)   
All databases (20)   

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ID   L0JQX6_NATP1            Unreviewed;       412 AA.
AC   L0JQX6;
DT   06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT   06-MAR-2013, sequence version 1.
DT   27-MAR-2024, entry version 63.
DE   RecName: Full=ORC1-type DNA replication protein {ECO:0000256|HAMAP-Rule:MF_01407};
GN   OrderedLocusNames=Natpe_3899 {ECO:0000313|EMBL:AGB33654.1};
GN   ORFNames=C488_21132 {ECO:0000313|EMBL:ELY68272.1};
OS   Natrinema pellirubrum (strain DSM 15624 / CIP 106293 / JCM 10476 / NCIMB
OS   786 / 157).
OG   Plasmid pNATPE01 {ECO:0000313|EMBL:AGB33654.1,
OG   ECO:0000313|Proteomes:UP000010843}.
OC   Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Natrialbales;
OC   Natrialbaceae; Natrinema.
OX   NCBI_TaxID=797303 {ECO:0000313|EMBL:AGB33654.1, ECO:0000313|Proteomes:UP000010843};
RN   [1] {ECO:0000313|EMBL:AGB33654.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=DSM 15624 {ECO:0000313|EMBL:AGB33654.1};
RC   PLASMID=pNATPE01 {ECO:0000313|EMBL:AGB33654.1};
RG   US DOE Joint Genome Institute;
RA   Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA   Peters L., Teshima H., Detter J.C., Han C., Tapia R., Land M., Hauser L.,
RA   Kyrpides N., Ivanova N., Pagani I., Sproer C., Anderson I., Woyke T.;
RT   "Complete sequence of plasmid 1 of Natrinema pellirubrum DSM 15624.";
RL   Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000010843}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 15624 / JCM 10476 / NCIMB 786
RC   {ECO:0000313|Proteomes:UP000010843};
RC   PLASMID=pNATPE01 {ECO:0000313|Proteomes:UP000010843};
RA   Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA   Peters L., Teshima H., Detter J.C., Han C., Tapia R., Land M., Hauser L.,
RA   Kyrpides N., Ivanova N., Pagani I., Sproer C., Anderson I., Woyke T.;
RT   "Complete sequence of plasmid 1 of Natrinema pellirubrum DSM 15624.";
RL   Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Proteomes:UP000011593}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 15624 {ECO:0000313|Proteomes:UP000011593};
RA   Becker E.A., Seitzer P., Tritt A., Larsen D., Yao A., Wu D., Darling A.,
RA   Eisen J.A., Facciotti M.T.;
RL   Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
RN   [4] {ECO:0000313|EMBL:ELY68272.1, ECO:0000313|Proteomes:UP000011593}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 15624 {ECO:0000313|EMBL:ELY68272.1,
RC   ECO:0000313|Proteomes:UP000011593};
RX   PubMed=25393412; DOI=10.1371/journal.pgen.1004784;
RA   Becker E.A., Seitzer P.M., Tritt A., Larsen D., Krusor M., Yao A.I., Wu D.,
RA   Madern D., Eisen J.A., Darling A.E., Facciotti M.T.;
RT   "Phylogenetically driven sequencing of extremely halophilic archaea reveals
RT   strategies for static and dynamic osmo-response.";
RL   PLoS Genet. 10:E1004784-E1004784(2014).
CC   -!- FUNCTION: Involved in regulation of DNA replication.
CC       {ECO:0000256|HAMAP-Rule:MF_01407}.
CC   -!- SIMILARITY: Belongs to the CDC6/cdc18 family. {ECO:0000256|HAMAP-
CC       Rule:MF_01407}.
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DR   EMBL; CP003373; AGB33654.1; -; Genomic_DNA.
DR   EMBL; AOIE01000133; ELY68272.1; -; Genomic_DNA.
DR   RefSeq; WP_006183554.1; NZ_AOIE01000133.1.
DR   AlphaFoldDB; L0JQX6; -.
DR   GeneID; 14336365; -.
DR   KEGG; npe:Natpe_3899; -.
DR   PATRIC; fig|797303.5.peg.4176; -.
DR   eggNOG; arCOG00467; Archaea.
DR   HOGENOM; CLU_025112_3_1_2; -.
DR   OrthoDB; 195574at2157; -.
DR   Proteomes; UP000010843; Plasmid pNATPE01.
DR   Proteomes; UP000011593; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd00009; AAA; 1.
DR   CDD; cd08768; Cdc6_C; 1.
DR   Gene3D; 1.10.8.60; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   HAMAP; MF_01407; ORC1_type_DNA_replic_protein; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR015163; Cdc6_C.
DR   InterPro; IPR014277; Orc1/Cdc6_arc.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   NCBIfam; TIGR02928; orc1/cdc6 family replication initiation protein; 1.
DR   PANTHER; PTHR10763; CELL DIVISION CONTROL PROTEIN 6-RELATED; 1.
DR   PANTHER; PTHR10763:SF22; ORC1-TYPE DNA REPLICATION PROTEIN 3; 1.
DR   Pfam; PF13401; AAA_22; 1.
DR   Pfam; PF09079; Cdc6_C; 1.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM01074; Cdc6_C; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW   Rule:MF_01407}; Cell cycle {ECO:0000313|EMBL:ELY68272.1};
KW   Cell division {ECO:0000313|EMBL:ELY68272.1};
KW   DNA replication {ECO:0000256|ARBA:ARBA00022705, ECO:0000256|HAMAP-
KW   Rule:MF_01407};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW   Rule:MF_01407}; Plasmid {ECO:0000313|EMBL:AGB33654.1}.
FT   DOMAIN          49..206
FT                   /note="AAA+ ATPase"
FT                   /evidence="ECO:0000259|SMART:SM00382"
FT   DOMAIN          302..385
FT                   /note="Cdc6 C-terminal"
FT                   /evidence="ECO:0000259|SMART:SM01074"
FT   BINDING         61..65
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_01407"
FT   BINDING         207
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_01407"
FT   BINDING         219
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_01407"
SQ   SEQUENCE   412 AA;  46614 MW;  38FC152524D679D8 CRC64;
     MGPRFQPDDT LYKRRNTLKV EYVPDDIVGR DNEIEEYEAA LQPIINGEYP DNIFIYGKTG
     VGKTAVTNFL LNELRDSAEH FAVDTAFVTV NCDGLSTSYQ AAINLVNNLR DPENHIAETG
     HPQSKVYRLL WDELNKLSGT VIIVLDEIDH ISDDTFLYQI TRADNNGYID NIQLGLIGIS
     NDSTFREQLD AKVQSSLCET EISFPPYGTE ELQKVLEQRA EIAFHQNALE EDVIPLCAAL
     GRQDGGDARR AITLLRKAGD LARTENASTV TTDLVERAQE KLEAQQSMDI MRDLTEHEQL
     TLYALTTLAA EDETPARSRI VYQRYKELCE FQARDPRTAR RMRSFLSDFE ILNLTLSHKE
     HRGQDGGTYR EHEINRDIAT VVDALQTTIS EFGAHRSIVD YLPDSGEEFA TM
//

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