ID L0JRJ3_NATP1 Unreviewed; 560 AA.
AC L0JRJ3;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE SubName: Full=AICAR transformylase/IMP cyclohydrolase PurH {ECO:0000313|EMBL:AGB33001.1};
DE SubName: Full=Phosphoribosylglycinamide formyltransferase {ECO:0000313|EMBL:ELY75105.1};
GN OrderedLocusNames=Natpe_3211 {ECO:0000313|EMBL:AGB33001.1};
GN ORFNames=C488_10136 {ECO:0000313|EMBL:ELY75105.1};
OS Natrinema pellirubrum (strain DSM 15624 / CIP 106293 / JCM 10476 / NCIMB
OS 786 / 157).
OC Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Natrialbales;
OC Natrialbaceae; Natrinema.
OX NCBI_TaxID=797303 {ECO:0000313|EMBL:AGB33001.1, ECO:0000313|Proteomes:UP000010843};
RN [1] {ECO:0000313|Proteomes:UP000010843}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 15624 / JCM 10476 / NCIMB 786
RC {ECO:0000313|Proteomes:UP000010843};
RA Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA Peters L., Teshima H., Detter J.C., Han C., Tapia R., Land M., Hauser L.,
RA Kyrpides N., Ivanova N., Pagani I., Sproer C., Anderson I., Woyke T.;
RT "Complete sequence of chromosome of Natrinema pellirubrum DSM 15624.";
RL Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AGB33001.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=DSM 15624 {ECO:0000313|EMBL:AGB33001.1};
RG US DOE Joint Genome Institute;
RA Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA Peters L., Teshima H., Detter J.C., Han C., Tapia R., Land M., Hauser L.,
RA Kyrpides N., Ivanova N., Pagani I., Sproer C., Anderson I., Woyke T.;
RT "Complete sequence of chromosome of Natrinema pellirubrum DSM 15624.";
RL Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Proteomes:UP000011593}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 15624 {ECO:0000313|Proteomes:UP000011593};
RA Becker E.A., Seitzer P., Tritt A., Larsen D., Yao A., Wu D., Darling A.,
RA Eisen J.A., Facciotti M.T.;
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:ELY75105.1, ECO:0000313|Proteomes:UP000011593}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 15624 {ECO:0000313|EMBL:ELY75105.1,
RC ECO:0000313|Proteomes:UP000011593};
RX PubMed=25393412; DOI=10.1371/journal.pgen.1004784;
RA Becker E.A., Seitzer P.M., Tritt A., Larsen D., Krusor M., Yao A.I., Wu D.,
RA Madern D., Eisen J.A., Darling A.E., Facciotti M.T.;
RT "Phylogenetically driven sequencing of extremely halophilic archaea reveals
RT strategies for static and dynamic osmo-response.";
RL PLoS Genet. 10:E1004784-E1004784(2014).
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DR EMBL; CP003372; AGB33001.1; -; Genomic_DNA.
DR EMBL; AOIE01000065; ELY75105.1; -; Genomic_DNA.
DR RefSeq; WP_006181404.1; NZ_AOIE01000065.1.
DR AlphaFoldDB; L0JRJ3; -.
DR STRING; 797303.Natpe_3211; -.
DR GeneID; 14333791; -.
DR KEGG; npe:Natpe_3211; -.
DR PATRIC; fig|797303.5.peg.2038; -.
DR eggNOG; arCOG02824; Archaea.
DR HOGENOM; CLU_016316_5_0_2; -.
DR OrthoDB; 52603at2157; -.
DR Proteomes; UP000010843; Chromosome.
DR Proteomes; UP000011593; Unassembled WGS sequence.
DR GO; GO:0003937; F:IMP cyclohydrolase activity; IEA:InterPro.
DR GO; GO:0004643; F:phosphoribosylaminoimidazolecarboxamide formyltransferase activity; IEA:InterPro.
DR GO; GO:0004644; F:phosphoribosylglycinamide formyltransferase activity; IEA:InterPro.
DR GO; GO:0006189; P:'de novo' IMP biosynthetic process; IEA:InterPro.
DR CDD; cd08645; FMT_core_GART; 1.
DR Gene3D; 3.40.140.20; -; 2.
DR Gene3D; 3.40.50.170; Formyl transferase, N-terminal domain; 1.
DR InterPro; IPR024051; AICAR_Tfase_dup_dom_sf.
DR InterPro; IPR016193; Cytidine_deaminase-like.
DR InterPro; IPR002376; Formyl_transf_N.
DR InterPro; IPR036477; Formyl_transf_N_sf.
DR InterPro; IPR004607; GART.
DR InterPro; IPR002695; PurH-like.
DR PANTHER; PTHR11692:SF0; BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN ATIC; 1.
DR PANTHER; PTHR11692; BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN PURH; 1.
DR Pfam; PF01808; AICARFT_IMPCHas; 1.
DR Pfam; PF00551; Formyl_trans_N; 1.
DR PIRSF; PIRSF000414; AICARFT_IMPCHas; 1.
DR SMART; SM00798; AICARFT_IMPCHas; 1.
DR SUPFAM; SSF53927; Cytidine deaminase-like; 1.
DR SUPFAM; SSF53328; Formyltransferase; 1.
PE 4: Predicted;
KW Purine biosynthesis {ECO:0000256|ARBA:ARBA00022755};
KW Transferase {ECO:0000313|EMBL:ELY75105.1}.
FT DOMAIN 10..190
FT /note="Formyl transferase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00551"
SQ SEQUENCE 560 AA; 60133 MW; B16F276626FB6492 CRC64;
MTRIAGMAGN RGRNLLNIAD RAPGGAAFAV ILATDPDAPV LEGAAEREIP TEVVPLEDDM
SRSEHEEAVL EALSDYEFDL VCLDGYMRIL SETFLEEAPT TLNVHPALLP SFPGMDAWGD
ALEAGVSVTG CTVHVVTDAT DEDGNVVEDD VDAGPIVTQE PIPVYEGDDE ADLKERVLYE
GEFRAYPRAV KWFAEGAVDV DLEAGEVTVD ADVASVDDAD HDGLPSRRLV SDDRADTLRY
GENPHQDAAV YTDYTTDEAS VVHADQLNEG AKGLSYNNYN DADGALNLIK EFDEPAAAVI
KHTNPAGCAT ADSLSDAYEK ALSTDPMSAF GGIVALNREC DAETAEQIID SFKEVVVAPG
YTDDALEVLF EKDNLRVLDV GREARSASDA SGEQPRALGE RTERFTEKPL VGGRLVQERD
LQSISVDDLE VVTEREPTDD ELETMVFAWQ TLKHVKSNGI LFADGTETVG IGMGQVSRVD
AVRLAAMKAD EHAEGKDAEG AVMASDAFFP FPDGIEEAAE AGIEAVVQPG GSVNDEDVIE
AADEHGMAMA FTGQRSFRHD
//
