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Database: UniProt
Entry: L0K9U6_HALHC
LinkDB: L0K9U6_HALHC
Original site: L0K9U6_HALHC 
ID   L0K9U6_HALHC            Unreviewed;       282 AA.
AC   L0K9U6;
DT   06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT   06-MAR-2013, sequence version 1.
DT   08-MAY-2019, entry version 34.
DE   RecName: Full=Prephenate dehydratase {ECO:0000256|RuleBase:RU361254};
DE            Short=PDT {ECO:0000256|RuleBase:RU361254};
DE            EC=4.2.1.51 {ECO:0000256|RuleBase:RU361254};
GN   Name=pheA {ECO:0000256|RuleBase:RU361254};
GN   OrderedLocusNames=Halha_1863 {ECO:0000313|EMBL:AGB41776.1};
OS   Halobacteroides halobius (strain ATCC 35273 / DSM 5150 / MD-1).
OC   Bacteria; Firmicutes; Clostridia; Halanaerobiales; Halobacteroidaceae;
OC   Halobacteroides.
OX   NCBI_TaxID=748449 {ECO:0000313|EMBL:AGB41776.1, ECO:0000313|Proteomes:UP000010880};
RN   [1] {ECO:0000313|Proteomes:UP000010880}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35273 / DSM 5150 / MD-1
RC   {ECO:0000313|Proteomes:UP000010880};
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E.,
RA   Tice H., Bruce D., Goodwin L., Pitluck S., Peters L., Mikhailova N.,
RA   Gu W., Kyrpides N., Mavromatis K., Ivanova N., Brettin T.,
RA   Detter J.C., Han C., Larimer F., Land M., Hauser L., Markowitz V.,
RA   Cheng J.-F., Hugenholtz P., Woyke T., Wu D., Tindall B., Pomrenke H.,
RA   Brambilla E., Klenk H.-P., Eisen J.A.;
RT   "The complete genome of Halobacteroides halobius DSM 5150.";
RL   Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H(+) + prephenate = 3-phenylpyruvate + CO2 + H2O;
CC         Xref=Rhea:RHEA:21648, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16526, ChEBI:CHEBI:18005, ChEBI:CHEBI:29934;
CC         EC=4.2.1.51; Evidence={ECO:0000256|RuleBase:RU361254};
CC   -!- PATHWAY: Amino-acid biosynthesis; L-phenylalanine biosynthesis;
CC       phenylpyruvate from prephenate: step 1/1.
CC       {ECO:0000256|RuleBase:RU361254}.
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DR   EMBL; CP003359; AGB41776.1; -; Genomic_DNA.
DR   RefSeq; WP_015327492.1; NC_019978.1.
DR   STRING; 748449.Halha_1863; -.
DR   EnsemblBacteria; AGB41776; AGB41776; Halha_1863.
DR   KEGG; hhl:Halha_1863; -.
DR   PATRIC; fig|748449.3.peg.1794; -.
DR   KO; K04518; -.
DR   OMA; HTRFVIL; -.
DR   OrthoDB; 1280729at2; -.
DR   BioCyc; HHAL748449:G1HE0-1834-MONOMER; -.
DR   UniPathway; UPA00121; UER00345.
DR   Proteomes; UP000010880; Chromosome.
DR   GO; GO:0004106; F:chorismate mutase activity; IEA:InterPro.
DR   GO; GO:0004664; F:prephenate dehydratase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0009094; P:L-phenylalanine biosynthetic process; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR002912; ACT_dom.
DR   InterPro; IPR008242; Chor_mutase/pphenate_deHydtase.
DR   InterPro; IPR001086; Preph_deHydtase.
DR   InterPro; IPR018528; Preph_deHydtase_CS.
DR   Pfam; PF01842; ACT; 1.
DR   Pfam; PF00800; PDT; 1.
DR   PIRSF; PIRSF001500; Chor_mut_pdt_Ppr; 1.
DR   PROSITE; PS51671; ACT; 1.
DR   PROSITE; PS00857; PREPHENATE_DEHYDR_1; 1.
DR   PROSITE; PS00858; PREPHENATE_DEHYDR_2; 1.
DR   PROSITE; PS51171; PREPHENATE_DEHYDR_3; 1.
PE   4: Predicted;
KW   Amino-acid biosynthesis {ECO:0000256|RuleBase:RU361254};
KW   Aromatic amino acid biosynthesis {ECO:0000256|RuleBase:RU361254};
KW   Complete proteome {ECO:0000313|Proteomes:UP000010880};
KW   Lyase {ECO:0000256|RuleBase:RU361254};
KW   Phenylalanine biosynthesis {ECO:0000256|RuleBase:RU361254};
KW   Reference proteome {ECO:0000313|Proteomes:UP000010880}.
FT   DOMAIN        2    179       Prephenate dehydratase.
FT                                {ECO:0000259|PROSITE:PS51171}.
FT   DOMAIN      192    269       ACT. {ECO:0000259|PROSITE:PS51671}.
FT   SITE        172    172       Essential for prephenate dehydratase
FT                                activity. {ECO:0000256|PIRSR:PIRSR001500-
FT                                2}.
SQ   SEQUENCE   282 AA;  31592 MW;  BAA906A1821154EA CRC64;
     MRLGFLGPQG SFTELAAQKY QGQVTEYLAY QDIKSLIKGV KAGAVDGAVT PIENSLEGSV
     TLTLDLLVEF DLKIRNEIII PIEHNLLVKN DINLEQIKHV ISHPQALAQC RSFLEDNLVD
     YQVHTANSTS EAVKELKNLE DDWAAIGNAR AARYYQLNLL KEGIQDNQEN WTRFVMLAKA
     DRSQTGNDKT SLICAAQMDR PGALYKILHE FAKRNINLTR IESRPAKKLL GDYIFFIDLE
     GHRADPRVKA ALSAVKKMTS LYKLLGSYPK STVIEDYLGI GK
//
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