ID L0KDN7_HALHC Unreviewed; 652 AA.
AC L0KDN7;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE RecName: Full=transketolase {ECO:0000256|ARBA:ARBA00013152};
DE EC=2.2.1.1 {ECO:0000256|ARBA:ARBA00013152};
GN OrderedLocusNames=Halha_2324 {ECO:0000313|EMBL:AGB42198.1};
OS Halobacteroides halobius (strain ATCC 35273 / DSM 5150 / MD-1).
OC Bacteria; Bacillota; Clostridia; Halanaerobiales; Halobacteroidaceae;
OC Halobacteroides.
OX NCBI_TaxID=748449 {ECO:0000313|EMBL:AGB42198.1, ECO:0000313|Proteomes:UP000010880};
RN [1] {ECO:0000313|Proteomes:UP000010880}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35273 / DSM 5150 / MD-1
RC {ECO:0000313|Proteomes:UP000010880};
RA Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA Bruce D., Goodwin L., Pitluck S., Peters L., Mikhailova N., Gu W.,
RA Kyrpides N., Mavromatis K., Ivanova N., Brettin T., Detter J.C., Han C.,
RA Larimer F., Land M., Hauser L., Markowitz V., Cheng J.-F., Hugenholtz P.,
RA Woyke T., Wu D., Tindall B., Pomrenke H., Brambilla E., Klenk H.-P.,
RA Eisen J.A.;
RT "The complete genome of Halobacteroides halobius DSM 5150.";
RL Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=D-glyceraldehyde 3-phosphate + D-sedoheptulose 7-phosphate =
CC aldehydo-D-ribose 5-phosphate + D-xylulose 5-phosphate;
CC Xref=Rhea:RHEA:10508, ChEBI:CHEBI:57483, ChEBI:CHEBI:57737,
CC ChEBI:CHEBI:58273, ChEBI:CHEBI:59776; EC=2.2.1.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001027};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- COFACTOR:
CC Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC Evidence={ECO:0000256|ARBA:ARBA00001964};
CC -!- SIMILARITY: Belongs to the transketolase family.
CC {ECO:0000256|ARBA:ARBA00007131}.
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DR EMBL; CP003359; AGB42198.1; -; Genomic_DNA.
DR RefSeq; WP_015327912.1; NC_019978.1.
DR AlphaFoldDB; L0KDN7; -.
DR STRING; 748449.Halha_2324; -.
DR KEGG; hhl:Halha_2324; -.
DR PATRIC; fig|748449.3.peg.2243; -.
DR eggNOG; COG0021; Bacteria.
DR HOGENOM; CLU_009227_0_0_9; -.
DR OrthoDB; 8732661at2; -.
DR Proteomes; UP000010880; Chromosome.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004802; F:transketolase activity; IEA:UniProtKB-EC.
DR CDD; cd07033; TPP_PYR_DXS_TK_like; 1.
DR CDD; cd02012; TPP_TK; 1.
DR Gene3D; 3.40.50.920; -; 1.
DR Gene3D; 3.40.50.970; -; 2.
DR InterPro; IPR029061; THDP-binding.
DR InterPro; IPR009014; Transketo_C/PFOR_II.
DR InterPro; IPR005475; Transketolase-like_Pyr-bd.
DR InterPro; IPR005478; Transketolase_bac-like.
DR InterPro; IPR049557; Transketolase_CS.
DR InterPro; IPR033247; Transketolase_fam.
DR InterPro; IPR005474; Transketolase_N.
DR NCBIfam; TIGR00232; tktlase_bact; 1.
DR PANTHER; PTHR43522; TRANSKETOLASE; 1.
DR PANTHER; PTHR43522:SF2; TRANSKETOLASE 1-RELATED; 1.
DR Pfam; PF02779; Transket_pyr; 1.
DR Pfam; PF00456; Transketolase_N; 1.
DR SMART; SM00861; Transket_pyr; 1.
DR SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 2.
DR SUPFAM; SSF52922; TK C-terminal domain-like; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
DR PROSITE; PS00801; TRANSKETOLASE_1; 1.
PE 3: Inferred from homology;
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000010880};
KW Thiamine pyrophosphate {ECO:0000256|ARBA:ARBA00023052};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 350..521
FT /note="Transketolase-like pyrimidine-binding"
FT /evidence="ECO:0000259|SMART:SM00861"
SQ SEQUENCE 652 AA; 72130 MW; 8E29F0CA05F4905A CRC64;
MLNKVADIVR GLSADTVEQA GSGHPGMAIG CADIGAALYG EIMNYDPTQP NWPNRDRFIL
SAGHGSVWLY SFLHLSGYDV SLEDLKRFRQ LHSKTPGHPE YGHTSGVETT TGPLGQGFAN
AVGMAISEKM LAERYNTKEY EIIDHYTYTL LGDGCMMEGV TSEAASLAGH LGLDKLIAIY
DSNDISIGGN VDITFTESVP DRFKAYDWHV IDEVDGHDIA SIKEAIAEAK EVTDKPTLII
ANTHIAYGAP TKQDSNSAHG APLGKEELTG LKENFGLPTD KEFYVSNEVR EFFATRQEKL
QKIRQDWEDR FTKWAKANPE LKTQWDQAHN LELPNDLERV VADIELDTPL ATRKASGSIL
RKIADQVPYL VGGSADLAPS NKTYLDKYEE IQKESFSGRN FRFGVREHAM GAIANGISLH
GGVRPFTATF LVFSDYMRPA IRMAALMKQP SIYVFTHDSI YIGEDGPTHQ PVEHVESLRL
IPNLEVIRPA DEEETKAAWL EAMKRQDGPT ALILTRQNLP HLKKDKKINM DKGGYVVQEG
NDPQVVLMAS GSEVSLAVEV AEKLDVETRV VSIPDRNKFI AQGQDYIKEV LGEDTFRVAL
EAGVGQGWYQ LLGDKHHLVS VEDFGASGSG EKVGKYFGFV AEEITEQIIN RL
//
