ID L0KLC5_MESAW Unreviewed; 652 AA.
AC L0KLC5;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE SubName: Full=Acetoacetyl-CoA synthase {ECO:0000313|EMBL:AGB44878.1};
GN OrderedLocusNames=Mesau_02451 {ECO:0000313|EMBL:AGB44878.1};
OS Mesorhizobium australicum (strain HAMBI 3006 / LMG 24608 / WSM2073).
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales;
OC Phyllobacteriaceae; Mesorhizobium.
OX NCBI_TaxID=754035 {ECO:0000313|EMBL:AGB44878.1, ECO:0000313|Proteomes:UP000010998};
RN [1] {ECO:0000313|Proteomes:UP000010998}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LMG 24608 / HAMBI 3006 / WSM2073
RC {ECO:0000313|Proteomes:UP000010998};
RA Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA Peters L., Gu W., Detter J.C., Han C., Tapia R., Land M., Hauser L.,
RA Kyrpides N., Ivanova N., Pagani I., Reeve W.G., Howieson J.G., Tiwari R.P.,
RA O'Hara G.W., Atkins C.A., Ronson C.W., Nandasena K.G., Woyke T.;
RT "Complete sequence of Mesorhizobium australicum WSM2073.";
RL Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP003358; AGB44878.1; -; Genomic_DNA.
DR RefSeq; WP_015316317.1; NC_019973.1.
DR AlphaFoldDB; L0KLC5; -.
DR STRING; 754035.Mesau_02451; -.
DR KEGG; mam:Mesau_02451; -.
DR eggNOG; COG0365; Bacteria.
DR HOGENOM; CLU_000022_3_3_5; -.
DR OrthoDB; 9803968at2; -.
DR Proteomes; UP000010998; Chromosome.
DR GO; GO:0030729; F:acetoacetate-CoA ligase activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0006629; P:lipid metabolic process; IEA:InterPro.
DR CDD; cd05943; AACS; 1.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR InterPro; IPR005914; Acac_CoA_synth.
DR InterPro; IPR032387; ACAS_N.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR NCBIfam; TIGR01217; ac_ac_CoA_syn; 1.
DR PANTHER; PTHR42921; ACETOACETYL-COA SYNTHETASE; 1.
DR PANTHER; PTHR42921:SF1; ACETOACETYL-COA SYNTHETASE; 1.
DR Pfam; PF16177; ACAS_N; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF13193; AMP-binding_C; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
PE 4: Predicted;
KW Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000010998}.
FT DOMAIN 38..93
FT /note="Acetyl-coenzyme A synthetase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16177"
FT DOMAIN 101..470
FT /note="AMP-dependent synthetase/ligase"
FT /evidence="ECO:0000259|Pfam:PF00501"
FT DOMAIN 542..614
FT /note="AMP-binding enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13193"
SQ SEQUENCE 652 AA; 71349 MW; CEBE5F7573A3E994 CRC64;
MAGEVPLWTP TQDQIDASPL TAFMKAAAAS TGSPFSSYAD LHRWSVENRE AFWGLVWDFC
GLEGDKGERL LLDGEKMPGA SFFPDASLNF AENLLRKTGA GEAIVFRGED KVERRLSWNE
LHGLVSRLQQ LFLSLKVKKG DRIAAMMPNM PEAVAAMLAA ASIGAVWSSC SPDFGEQGVL
DRFGQIEPVI FIAPDGYWYN GKAIEVADKI KAVAARLGGV RKVLLVDYLG TSADVADTID
KAVAMEEALS PFAVRPVTFE RLPFSHPLYI LFSSGTTGVP KCIVHSAGGT LIQHVKEHRL
HAGLGDGDRF FYFTTCGWMM WNWLVSGLAS GATLLLYDGS PFYPDGNVLF DFADAEKMTF
FGTSAKFIDS VRKAGLKPIR SHDLSTIRAI SSTGSPLSPE DFRFVYDGIK KDVHLASVSG
GTDIVSCFVL GVPTQPVWTG EIQGPGLGLA VDVWDDDGKP VRQEKGELVC TRAFPSMPIG
FWNDPDGRKY QAAYFERFDN VWCHGDFAEW TDHGGMVIHG RSDATLNPGG VRIGTAEIYN
QVEQMPEILE ALCIGQDFDN DVRVVLFVRL AAGVKLDDDL YKRIRAKIRG GASPRHVPAR
IVAVSDIPRT KSGKITELAV RDVVHGRAIK NKEALANPEA LELFRDLPQL AQ
//
