ID   L0KPE5_MESAW            Unreviewed;       817 AA.
AC   L0KPE5;
DT   06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT   06-MAR-2013, sequence version 1.
DT   27-MAR-2024, entry version 53.
DE   SubName: Full=Glycine cleavage system T protein (Aminomethyltransferase) {ECO:0000313|EMBL:AGB45973.1};
GN   OrderedLocusNames=Mesau_03612 {ECO:0000313|EMBL:AGB45973.1};
OS   Mesorhizobium australicum (strain HAMBI 3006 / LMG 24608 / WSM2073).
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales;
OC   Phyllobacteriaceae; Mesorhizobium.
OX   NCBI_TaxID=754035 {ECO:0000313|EMBL:AGB45973.1, ECO:0000313|Proteomes:UP000010998};
RN   [1] {ECO:0000313|Proteomes:UP000010998}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LMG 24608 / HAMBI 3006 / WSM2073
RC   {ECO:0000313|Proteomes:UP000010998};
RA   Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA   Peters L., Gu W., Detter J.C., Han C., Tapia R., Land M., Hauser L.,
RA   Kyrpides N., Ivanova N., Pagani I., Reeve W.G., Howieson J.G., Tiwari R.P.,
RA   O'Hara G.W., Atkins C.A., Ronson C.W., Nandasena K.G., Woyke T.;
RT   "Complete sequence of Mesorhizobium australicum WSM2073.";
RL   Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the GcvT family.
CC       {ECO:0000256|ARBA:ARBA00008609}.
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DR   EMBL; CP003358; AGB45973.1; -; Genomic_DNA.
DR   RefSeq; WP_015317392.1; NC_019973.1.
DR   AlphaFoldDB; L0KPE5; -.
DR   STRING; 754035.Mesau_03612; -.
DR   KEGG; mam:Mesau_03612; -.
DR   eggNOG; COG0404; Bacteria.
DR   eggNOG; COG0665; Bacteria.
DR   HOGENOM; CLU_007884_11_0_5; -.
DR   OrthoDB; 9804379at2; -.
DR   Proteomes; UP000010998; Chromosome.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   Gene3D; 2.40.30.110; Aminomethyltransferase beta-barrel domains; 1.
DR   Gene3D; 3.30.70.1400; Aminomethyltransferase beta-barrel domains; 1.
DR   Gene3D; 3.30.9.10; D-Amino Acid Oxidase, subunit A, domain 2; 1.
DR   Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR   InterPro; IPR006076; FAD-dep_OxRdtase.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR032503; FAO_M.
DR   InterPro; IPR013977; GCV_T_C.
DR   InterPro; IPR006222; GCV_T_N.
DR   InterPro; IPR029043; GcvT/YgfZ_C.
DR   InterPro; IPR027266; TrmE/GcvT_dom1.
DR   PANTHER; PTHR13847:SF187; DIMETHYLGLYCINE DEHYDROGENASE, MITOCHONDRIAL; 1.
DR   PANTHER; PTHR13847; SARCOSINE DEHYDROGENASE-RELATED; 1.
DR   Pfam; PF01266; DAO; 1.
DR   Pfam; PF16350; FAO_M; 1.
DR   Pfam; PF01571; GCV_T; 1.
DR   Pfam; PF08669; GCV_T_C; 1.
DR   SUPFAM; SSF101790; Aminomethyltransferase beta-barrel domain; 1.
DR   SUPFAM; SSF54373; FAD-linked reductases, C-terminal domain; 1.
DR   SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR   SUPFAM; SSF103025; Folate-binding domain; 1.
PE   3: Inferred from homology;
KW   Methyltransferase {ECO:0000313|EMBL:AGB45973.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000010998};
KW   Transferase {ECO:0000313|EMBL:AGB45973.1}.
FT   DOMAIN          9..373
FT                   /note="FAD dependent oxidoreductase"
FT                   /evidence="ECO:0000259|Pfam:PF01266"
FT   DOMAIN          377..431
FT                   /note="FAD dependent oxidoreductase central"
FT                   /evidence="ECO:0000259|Pfam:PF16350"
FT   DOMAIN          434..703
FT                   /note="Aminomethyltransferase folate-binding"
FT                   /evidence="ECO:0000259|Pfam:PF01571"
FT   DOMAIN          728..809
FT                   /note="Glycine cleavage T-protein C-terminal barrel"
FT                   /evidence="ECO:0000259|Pfam:PF08669"
SQ   SEQUENCE   817 AA;  91454 MW;  ADB8261DCC9AE405 CRC64;
     MAGLPSTARV VIIGGGVVGT SSLYHLAKAG WTDCVLLEKN ELTSGSTWHA AGNVPTFSSS
     WSLMNMQRYS TELYRGLADA VDYPMNYHVT GSLRLAHTKE RIQEFQRAKG MGRYQGMDID
     VIGLDEIKRR YPFLETHELK GALYDPSDGD IDPAQLTQAL AKGARDMGAK IIRFCPVTGV
     RREKDEWVVE TPQGEIRCEI VVNAAGYRAA EVGRMFGREV PMMVMSHQYI LFEEIPELAA
     WSKEQGKKLP LLRDVDTSYY LRQEKAGMNL GPYERNCRAH WATHNDPMPD DFSFQLFPDD
     LDRLEHYLAD AVARVPILGT AGLSKVINGP IPYAPDGNPL IGPMPGVPNA FEACVFTFGI
     AQGGGAGKVL AEWVTQGQTE WDMWSCDPRR FTSFASAPDY CVAKGMEIYG NEYAIQFPRH
     AWPEGRDRKL SPIHDRIKAL GARFDAYNGW ERATWYARDG DDVSEEATLT FRRDGPWQQR
     VREECLAVRD AAGILDLPGF SRFNLEGPGA AEWLSRQVTG LVPKPGRIGL VYFSDDKGRI
     VTEMSVVRHG EESMTLITAA VAQWHDFEWL KSHMPGDAAF KLIDRTEEFS TQILAGPNSR
     KILADVCDAD LTLPWLTHQE TRIAGRWARL VRVSFAGELG WEIHTRVDDT AAIFDTICAA
     GQNHGLKPFG MYALDSLRLE KGYRTWKGDL STDYSILQGG LERFVKWEKP DFRGKAALQN
     EKQQGVKKRF VTLVVEDPGD CDAPYMSTLW HDGQIVGETT SGGWGHRVDK SIALGMLRAD
     LTEPGTSVEV EIFGDRFKAI VQQDEPLWDP RNERLRA
//