ID L0KVR7_MESAW Unreviewed; 440 AA.
AC L0KVR7;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE SubName: Full=Beta-hydroxyacid dehydrogenase, 3-hydroxyisobutyrate dehydrogenase {ECO:0000313|EMBL:AGB48074.1};
GN OrderedLocusNames=Mesau_05816 {ECO:0000313|EMBL:AGB48074.1};
OS Mesorhizobium australicum (strain HAMBI 3006 / LMG 24608 / WSM2073).
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales;
OC Phyllobacteriaceae; Mesorhizobium.
OX NCBI_TaxID=754035 {ECO:0000313|EMBL:AGB48074.1, ECO:0000313|Proteomes:UP000010998};
RN [1] {ECO:0000313|Proteomes:UP000010998}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LMG 24608 / HAMBI 3006 / WSM2073
RC {ECO:0000313|Proteomes:UP000010998};
RA Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA Peters L., Gu W., Detter J.C., Han C., Tapia R., Land M., Hauser L.,
RA Kyrpides N., Ivanova N., Pagani I., Reeve W.G., Howieson J.G., Tiwari R.P.,
RA O'Hara G.W., Atkins C.A., Ronson C.W., Nandasena K.G., Woyke T.;
RT "Complete sequence of Mesorhizobium australicum WSM2073.";
RL Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; CP003358; AGB48074.1; -; Genomic_DNA.
DR RefSeq; WP_013533465.1; NC_019973.1.
DR AlphaFoldDB; L0KVR7; -.
DR STRING; 754035.Mesau_05816; -.
DR KEGG; mam:Mesau_05816; -.
DR eggNOG; COG2084; Bacteria.
DR HOGENOM; CLU_035117_1_1_5; -.
DR OrthoDB; 9812907at2; -.
DR Proteomes; UP000010998; Chromosome.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:UniProt.
DR GO; GO:0016054; P:organic acid catabolic process; IEA:UniProt.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR006115; 6PGDH_NADP-bd.
DR InterPro; IPR029154; HIBADH-like_NADP-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR22981:SF7; 3-HYDROXYISOBUTYRATE DEHYDROGENASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR22981; 3-HYDROXYISOBUTYRATE DEHYDROGENASE-RELATED; 1.
DR Pfam; PF14833; NAD_binding_11; 1.
DR Pfam; PF03446; NAD_binding_2; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000010998}.
FT DOMAIN 17..177
FT /note="6-phosphogluconate dehydrogenase NADP-binding"
FT /evidence="ECO:0000259|Pfam:PF03446"
FT DOMAIN 180..299
FT /note="3-hydroxyisobutyrate dehydrogenase-like NAD-binding"
FT /evidence="ECO:0000259|Pfam:PF14833"
SQ SEQUENCE 440 AA; 47392 MW; 9AC04E7349FBDFA5 CRC64;
MSTVEAAPAA LFGNAERIGF VGTGSMGRPM IAKLLEAGYL VNVYDIDPAA AKDVVEKGAR
WHDAPCDAAR DCEIVITCLP MPRDVFDNMT GEQGAMAGMP PGGVWIDAST TDYHNTIEIA
RRAAAIGVYS LEAPVSNLSH MGVDFGNVSF FVGGPLEAYV RCEAALQAMG AVSFHVGNIG
QGQSVKLLTN LLFYAAAVAS GDALCRSVRD GVPAQQAWRK FVGSSANSVA VEQFVPFLLD
GSYDRSCTLE ITMKDMDLTV QLADELGVGL PIGRTIEERY SLAGRKFDRH DSHLSVVELA
QAAYGAGLQV PGYRAPSKYG ADPAHPPDQE FLTDPVGRIK PKREHMFPLE DVPLSDVQIR
LLESLSVELT NLNRLILDEA FDLGRGMGLS DALIHDVITW SVGASAWSDS HAQQYGNRQP
IAPPLTNVPH LIYPYTEELS
//
