ID L0KYQ5_METHD Unreviewed; 254 AA.
AC L0KYQ5;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=Methyltransferase cognate corrinoid protein {ECO:0000313|EMBL:AGB49795.1};
GN OrderedLocusNames=Metho_1599 {ECO:0000313|EMBL:AGB49795.1};
OS Methanomethylovorans hollandica (strain DSM 15978 / NBRC 107637 / DMS1).
OC Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC Methanosarcinales; Methanosarcinaceae; Methanomethylovorans.
OX NCBI_TaxID=867904 {ECO:0000313|EMBL:AGB49795.1, ECO:0000313|Proteomes:UP000010866};
RN [1] {ECO:0000313|Proteomes:UP000010866}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 15978 / NBRC 107637 / DMS1
RC {ECO:0000313|Proteomes:UP000010866};
RA Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA Bruce D., Goodwin L., Pitluck S., Peters L., Mikhailova N., Held B.,
RA Kyrpides N., Mavromatis K., Ivanova N., Brettin T., Detter J.C., Han C.,
RA Larimer F., Land M., Hauser L., Markowitz V., Cheng J.-F., Hugenholtz P.,
RA Woyke T., Wu D., Spring S., Schroeder M., Brambilla E., Klenk H.-P.,
RA Eisen J.A.;
RT "Complete sequence of chromosome of Methanomethylovorans hollandica DSM
RT 15978.";
RL Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the methylamine corrinoid protein family.
CC {ECO:0000256|ARBA:ARBA00010854}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP003362; AGB49795.1; -; Genomic_DNA.
DR RefSeq; WP_015324960.1; NC_019977.1.
DR AlphaFoldDB; L0KYQ5; -.
DR STRING; 867904.Metho_1599; -.
DR GeneID; 14406112; -.
DR KEGG; mhz:Metho_1599; -.
DR HOGENOM; CLU_082102_0_0_2; -.
DR OrthoDB; 134276at2157; -.
DR Proteomes; UP000010866; Chromosome.
DR GO; GO:0031419; F:cobalamin binding; IEA:InterPro.
DR GO; GO:0050897; F:cobalt ion binding; IEA:InterPro.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0015948; P:methanogenesis; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.280; Cobalamin-binding domain; 1.
DR Gene3D; 1.10.1240.10; Methionine synthase domain; 1.
DR InterPro; IPR003759; Cbl-bd_cap.
DR InterPro; IPR006158; Cobalamin-bd.
DR InterPro; IPR036724; Cobalamin-bd_sf.
DR InterPro; IPR012741; Corrinoid_p.
DR InterPro; IPR036594; Meth_synthase_dom.
DR NCBIfam; NF040655; MtaC_Meth; 1.
DR NCBIfam; TIGR02370; pyl_corrinoid; 1.
DR PANTHER; PTHR45833; METHIONINE SYNTHASE; 1.
DR PANTHER; PTHR45833:SF1; METHIONINE SYNTHASE; 1.
DR Pfam; PF02310; B12-binding; 1.
DR Pfam; PF02607; B12-binding_2; 1.
DR SMART; SM01018; B12-binding_2; 1.
DR SUPFAM; SSF52242; Cobalamin (vitamin B12)-binding domain; 1.
DR SUPFAM; SSF47644; Methionine synthase domain; 1.
DR PROSITE; PS51332; B12_BINDING; 1.
DR PROSITE; PS51337; B12_BINDING_NTER; 1.
PE 3: Inferred from homology;
KW Cobalt {ECO:0000256|ARBA:ARBA00023285};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Methyltransferase {ECO:0000313|EMBL:AGB49795.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000010866};
KW Transferase {ECO:0000313|EMBL:AGB49795.1}.
FT DOMAIN 27..121
FT /note="B12-binding N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51337"
FT DOMAIN 120..249
FT /note="B12-binding"
FT /evidence="ECO:0000259|PROSITE:PS51332"
SQ SEQUENCE 254 AA; 27966 MW; 6943ADBAABF61F20 CRC64;
MINIDPSAIL VRYNVKAEKE ISPEEIARQL YTEDIVIRPI VEAVFEGDED DVIEALEAAI
RAGRDPLSLI DDALMQGMGI VSKLYDDGFL FLPDVIISAH AMTDGIEYCK HSSSATHEFK
GKVVSFVVEG DMHDIGKKIV TVLLRASGYE VIDLGSDVLV SEVISAVRRE KPVMLSGTAL
MTTTMYTFKE INNQLLENGI HIPFVCGGGA VKQDFVFGYE LGVYCEDAAD APKIADEILK
GAGVKELREK YHRH
//
