ID   L0KZG6_METHD            Unreviewed;       838 AA.
AC   L0KZG6;
DT   06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT   06-MAR-2013, sequence version 1.
DT   27-MAR-2024, entry version 50.
DE   RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE            EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN   OrderedLocusNames=Metho_1265 {ECO:0000313|EMBL:AGB49493.1};
OS   Methanomethylovorans hollandica (strain DSM 15978 / NBRC 107637 / DMS1).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC   Methanosarcinales; Methanosarcinaceae; Methanomethylovorans.
OX   NCBI_TaxID=867904 {ECO:0000313|EMBL:AGB49493.1, ECO:0000313|Proteomes:UP000010866};
RN   [1] {ECO:0000313|Proteomes:UP000010866}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 15978 / NBRC 107637 / DMS1
RC   {ECO:0000313|Proteomes:UP000010866};
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA   Bruce D., Goodwin L., Pitluck S., Peters L., Mikhailova N., Held B.,
RA   Kyrpides N., Mavromatis K., Ivanova N., Brettin T., Detter J.C., Han C.,
RA   Larimer F., Land M., Hauser L., Markowitz V., Cheng J.-F., Hugenholtz P.,
RA   Woyke T., Wu D., Spring S., Schroeder M., Brambilla E., Klenk H.-P.,
RA   Eisen J.A.;
RT   "Complete sequence of chromosome of Methanomethylovorans hollandica DSM
RT   15978.";
RL   Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC         histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
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DR   EMBL; CP003362; AGB49493.1; -; Genomic_DNA.
DR   RefSeq; WP_015324659.1; NC_019977.1.
DR   AlphaFoldDB; L0KZG6; -.
DR   STRING; 867904.Metho_1265; -.
DR   GeneID; 14407074; -.
DR   KEGG; mhz:Metho_1265; -.
DR   HOGENOM; CLU_339705_0_0_2; -.
DR   OrthoDB; 8127at2157; -.
DR   Proteomes; UP000010866; Chromosome.
DR   GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   CDD; cd00075; HATPase; 1.
DR   CDD; cd00130; PAS; 2.
DR   Gene3D; 3.30.450.40; -; 2.
DR   Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR   Gene3D; 3.30.450.20; PAS domain; 2.
DR   InterPro; IPR003018; GAF.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR003594; HATPase_C.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR005467; His_kinase_dom.
DR   InterPro; IPR001610; PAC.
DR   InterPro; IPR000014; PAS.
DR   InterPro; IPR000700; PAS-assoc_C.
DR   InterPro; IPR035965; PAS-like_dom_sf.
DR   InterPro; IPR013655; PAS_fold_3.
DR   InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR   NCBIfam; TIGR00229; sensory_box; 2.
DR   PANTHER; PTHR43304:SF1; PAC DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR43304; PHYTOCHROME-LIKE PROTEIN CPH1; 1.
DR   Pfam; PF13185; GAF_2; 2.
DR   Pfam; PF02518; HATPase_c; 1.
DR   Pfam; PF08447; PAS_3; 1.
DR   Pfam; PF13426; PAS_9; 1.
DR   PRINTS; PR00344; BCTRLSENSOR.
DR   SMART; SM00065; GAF; 2.
DR   SMART; SM00387; HATPase_c; 1.
DR   SMART; SM00086; PAC; 2.
DR   SMART; SM00091; PAS; 2.
DR   SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR   SUPFAM; SSF55781; GAF domain-like; 2.
DR   SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 2.
DR   PROSITE; PS50109; HIS_KIN; 1.
DR   PROSITE; PS50113; PAC; 2.
DR   PROSITE; PS50112; PAS; 2.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000010866}.
FT   DOMAIN          42..79
FT                   /note="PAS"
FT                   /evidence="ECO:0000259|PROSITE:PS50112"
FT   DOMAIN          83..135
FT                   /note="PAC"
FT                   /evidence="ECO:0000259|PROSITE:PS50113"
FT   DOMAIN          302..372
FT                   /note="PAS"
FT                   /evidence="ECO:0000259|PROSITE:PS50112"
FT   DOMAIN          374..424
FT                   /note="PAC"
FT                   /evidence="ECO:0000259|PROSITE:PS50113"
FT   DOMAIN          643..834
FT                   /note="Histidine kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50109"
SQ   SEQUENCE   838 AA;  96003 MW;  A99E5EB2CB14E278 CRC64;
     MAQFDISAET LRLINESPMT IFVWRAEQGW PVEFVSENVR QFGYSPEDFL SGKIKYEDII
     HPDDIEEIHI RFATCIKEGD SNFSHEYRVL TKSGDIRWVY ERTIIRRDQN SNIQYYEGII
     LDISNRKLSE IIINCRNRVL ESLASGASLD EVLTHLVKMS ERAIPESIGF VMLLDKERKH
     LIRAISPLLP GFYKKAIESL PIEEGSSSCG TAAYTGKRII VENIMEHPYW KDMKEFASQV
     GIKSSCCEPI MSSNNEVLGT FEIYFREPHI PTKEEIEILK ANANLAAIAI NHKIATDALC
     ESEQKLKGIF NSINDQLYIS ELNGKLIYVN QVVVDTLGYS KEEILSTSPV DIVTSKYLQR
     MPELLKIIET KGRAIYETEA IIKDGTIIPL EINARFIVYN GKKMVLSVAR DITERKKAER
     KSQLEEKRLD ALVKLNGMVG SSLEEITDFA REEAVKLTES TLGYLAFMNA DETELIMHSW
     SESAMKECGI KDKRFIYPIK TTGLWGEAVR QRKPIITNDY PAPNTMKKGY PEDHVKLIRH
     MNVPIFDGDH IIAVVGVGNK EEEYNDSDLR QLILLMQGMW SLIQRKQMED ALKKYSEELT
     KANKGLRSIR RMKTEFVAER MDLFEAEQTE CSIMDDETIR VIDDQQAKSI DSVMLNSERL
     KRLVDSLLYM SLEQAGKIKY SFFPVHIDNL ISEALMNLIL LIDEKMIIVD TNIPKELSTV
     RADRDKLTET FINLIDNAVM FTPVGGRISI DLSEEKEHQH IRITDTGPGI QKDLIPHLFH
     KFYQMEDSMS RRYQGLESGL YISKNIILAH QGQIWIESEM GKGTTFHIKL PICKDNLC
//