ID L0M7J0_ENTBF Unreviewed; 781 AA.
AC L0M7J0;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN OrderedLocusNames=D782_3935 {ECO:0000313|EMBL:AGB79838.1};
OS Enterobacteriaceae bacterium (strain FGI 57).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae.
OX NCBI_TaxID=693444 {ECO:0000313|EMBL:AGB79838.1, ECO:0000313|Proteomes:UP000011002};
RN [1] {ECO:0000313|EMBL:AGB79838.1, ECO:0000313|Proteomes:UP000011002}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FGI 57 {ECO:0000313|EMBL:AGB79838.1,
RC ECO:0000313|Proteomes:UP000011002};
RX PubMed=23469353; DOI=10.1128/genomeA.00238-12;
RA Aylward F.O., Tremmel D.M., Bruce D.C., Chain P., Chen A.,
RA Walston Davenport K., Detter C., Han C.S., Han J., Huntemann M.,
RA Ivanova N.N., Kyrpides N.C., Markowitz V., Mavrommatis K., Nolan M.,
RA Pagani I., Pati A., Pitluck S., Deshpande S., Goodwin L., Woyke T.,
RA Currie C.R.;
RT "Complete genome of Enterobacteriaceae bacterium strain FGI 57, a strain
RT associated with leaf-cutter ant fungus gardens.";
RL Genome Announc. 1:E00238-12(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
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DR EMBL; CP003938; AGB79838.1; -; Genomic_DNA.
DR AlphaFoldDB; L0M7J0; -.
DR STRING; 693444.D782_3935; -.
DR REBASE; 58853; M.Eba57ORF3935P.
DR KEGG; ebf:D782_3935; -.
DR PATRIC; fig|693444.3.peg.3757; -.
DR eggNOG; COG0286; Bacteria.
DR HOGENOM; CLU_012122_1_1_6; -.
DR OrthoDB; 9784823at2; -.
DR Proteomes; UP000011002; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR GO; GO:0009307; P:DNA restriction-modification system; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1260.30; -; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR022749; D12N6_MeTrfase_N.
DR InterPro; IPR003356; DNA_methylase_A-5.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR038333; T1MK-like_N_sf.
DR PANTHER; PTHR42933; SLR6095 PROTEIN; 1.
DR PANTHER; PTHR42933:SF3; TYPE I RESTRICTION ENZYME MJAVIII METHYLASE SUBUNIT; 1.
DR Pfam; PF12161; HsdM_N; 1.
DR Pfam; PF02384; N6_Mtase; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:AGB79838.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000011002};
KW Restriction system {ECO:0000256|ARBA:ARBA00022747};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:AGB79838.1}.
FT DOMAIN 9..143
FT /note="N6 adenine-specific DNA methyltransferase N-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF12161"
FT DOMAIN 155..455
FT /note="DNA methylase adenine-specific"
FT /evidence="ECO:0000259|Pfam:PF02384"
SQ SEQUENCE 781 AA; 87049 MW; 45920F618A3F5B54 CRC64;
MSSTNFSQIA AFLWSVADLL RGDFKQSQYG RIILPFTLLR RLECVLETTK DAVIAEAHKV
KAMKLPEEAQ EKMILRATKG LTFFNASAMD LSKMGQNGIQ DNLENYIQSF SSDAREIFEH
FKFSEFVGQL ADANLLFKVV QIFAKADLYP EHVTNHDMGL VFEELIRRFA ESSNETAGEH
FTPRDIVNLT TSLVFFDDDD ALNKDGIIRT IYDPTAGTGG FLSSGMEYVH KQNPNAVMRA
FGQELNPESY AICKADMLIK GQDVSLIKLG NTLSNDQLPA EKFDYMLSNP PFGVDWKKIE
GDINDEHKLK GADGRFGPGL PRVSDGSLLF LLHLISKMRD AKSGGGRIGI ILNGSPLFTG
GAGSGESEIR RYILEADLLE GIIALPTDMF YNTGIATYVW VLSNKKAPER KGKVQLIDGS
NLCGKMRKSL GSKRNILGEE DIRLITRTFG DFEPVATTTL AALGMEKAPE QKSSRGRQPT
TTKTEAAKTF ASKVFYSTDF GYRRITVERP LRLSAQMTDD AIATLRFAPK PFNAPMAQLY
DAFAFHWQDG NYGDLTAVES EARAILKADF SELKEKQIKD LLDSKLWLAQ RTLMEKAQRV
QAAMGMLAGG KETVSNDFNQ FQLTLKEAFK TAGVKLDAKE NKQFIDAITR KNPDAEPVIS
KVLKEAAQPL YGAFEYHGKV VEFEPDGDLR DNENVPLNPS VSTSELIEGY FKAEVLPHVA
DAWINADKRD AKDGDIGTVG YEIPFNRHFY VYQPPRPLEE IDADLDAVSA EIMQMLREVY
S
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