ID L0MNN2_9GAMM Unreviewed; 549 AA.
AC L0MNN2;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=Na+ antiporter {ECO:0000313|EMBL:AGB84346.1};
GN ORFNames=D781_4160 {ECO:0000313|EMBL:AGB84346.1};
OS Serratia sp. FGI94.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Yersiniaceae; Serratia.
OX NCBI_TaxID=671990 {ECO:0000313|EMBL:AGB84346.1, ECO:0000313|Proteomes:UP000011001};
RN [1] {ECO:0000313|EMBL:AGB84346.1, ECO:0000313|Proteomes:UP000011001}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FGI94 {ECO:0000313|EMBL:AGB84346.1,
RC ECO:0000313|Proteomes:UP000011001};
RX PubMed=23516234;
RA Aylward F.O., Tremmel D.M., Starrett G.J., Bruce D.C., Chain P., Chen A.,
RA Davenport K.W., Detter C., Han C.S., Han J., Huntemann M., Ivanova N.N.,
RA Kyrpides N.C., Markowitz V., Mavrommatis K., Nolan M., Pagani I., Pati A.,
RA Pitluck S., Teshima H., Deshpande S., Goodwin L., Woyke T., Currie C.R.;
RT "Complete Genome of Serratia sp. Strain FGI 94, a Strain Associated with
RT Leaf-Cutter Ant Fungus Gardens.";
RL Genome Announc. 1:E0023912-E0023912(2013).
CC -!- FUNCTION: Na(+)/H(+) antiporter that extrudes sodium in exchange for
CC external protons. {ECO:0000256|RuleBase:RU366002}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|RuleBase:RU366002}; Multi-pass membrane protein
CC {ECO:0000256|RuleBase:RU366002}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 1 (CPA1)
CC transporter (TC 2.A.36) family. {ECO:0000256|RuleBase:RU366002}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU366002}.
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DR EMBL; CP003942; AGB84346.1; -; Genomic_DNA.
DR RefSeq; WP_015962058.1; NC_020064.1.
DR AlphaFoldDB; L0MNN2; -.
DR KEGG; smaf:D781_4160; -.
DR PATRIC; fig|1249634.3.peg.3989; -.
DR eggNOG; COG0025; Bacteria.
DR HOGENOM; CLU_005912_6_3_6; -.
DR OrthoDB; 9809206at2; -.
DR Proteomes; UP000011001; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015385; F:sodium:proton antiporter activity; IEA:InterPro.
DR Gene3D; 6.10.140.1330; -; 1.
DR InterPro; IPR006153; Cation/H_exchanger.
DR InterPro; IPR018422; Cation/H_exchanger_CPA1.
DR InterPro; IPR004705; Cation/H_exchanger_CPA1_bac.
DR NCBIfam; TIGR00831; a_cpa1; 1.
DR PANTHER; PTHR10110; SODIUM/HYDROGEN EXCHANGER; 1.
DR PANTHER; PTHR10110:SF86; SODIUM_HYDROGEN EXCHANGER 7; 1.
DR Pfam; PF00999; Na_H_Exchanger; 1.
PE 3: Inferred from homology;
KW Antiport {ECO:0000256|ARBA:ARBA00022449, ECO:0000256|RuleBase:RU366002};
KW Cell inner membrane {ECO:0000256|RuleBase:RU366002};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU366002};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU366002};
KW Sodium {ECO:0000256|ARBA:ARBA00023053, ECO:0000256|RuleBase:RU366002};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW ECO:0000256|RuleBase:RU366002};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU366002};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU366002};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU366002}.
FT TRANSMEM 85..105
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU366002"
FT TRANSMEM 111..136
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU366002"
FT TRANSMEM 157..179
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU366002"
FT TRANSMEM 241..260
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU366002"
FT TRANSMEM 272..294
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU366002"
FT TRANSMEM 314..338
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU366002"
FT TRANSMEM 359..385
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU366002"
FT TRANSMEM 397..420
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU366002"
FT DOMAIN 8..421
FT /note="Cation/H+ exchanger"
FT /evidence="ECO:0000259|Pfam:PF00999"
SQ SEQUENCE 549 AA; 59807 MW; 32CE1DA17604AFCC CRC64;
MEIFFTILIL ILVVSLSGVV TRMLPFQVPL PLMQIAIGAL LAWPHFGLHV DFDPELFLVL
FIPPLLFADG WKTPMREFIH HGREVLGLAL VLVLITVVGV GYLIYLMVPG IPLVAAFALA
AVLSPTDAVA LSGIVGKGRI PKPIMGVLEG EALMNDASGL VSLKFAIAVA MGTMVFTVGG
ATLEFLKVAI GGLLAGVAVT WTYSKSLRVM SRWSGDDPAT QIVFLLLLPF ASYLIAEHIG
VSGILAAVAA GMTISQSGVI RNAPLAMRLR ANSVWAMLEF VFNGMVFIML GLQLPGILET
SILQAELDPT IQTWYLFADV AIIYAALLLL RFTWLWLMKG ASKRLLKKRP LQFGNYTTRE
LWVASFAGVR GAITLAGVLS IPLLLSDGSA FPARYQLVFI AAGVILLSLI VGVIALPLLL
RGVQVADPSV SKGEERMAIA MAAEVAIESI NKMEERLTAD TEENIDPQVL KEVSSRVVGM
LRRRVASKDD IENALELENL ERRFRLTALR AERGELYHLR ATQKISNETL QKLLHDLDLL
EALLVEREG
//
