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Database: UniProt
Entry: L0PCC5_PNEJ8
LinkDB: L0PCC5_PNEJ8
Original site: L0PCC5_PNEJ8 
ID   L0PCC5_PNEJ8            Unreviewed;       515 AA.
AC   L0PCC5;
DT   06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT   06-MAR-2013, sequence version 1.
DT   16-JAN-2019, entry version 34.
DE   RecName: Full=Serine/threonine-protein phosphatase {ECO:0000256|RuleBase:RU004273};
DE            EC=3.1.3.16 {ECO:0000256|RuleBase:RU004273};
GN   ORFNames=PNEJI1_001511 {ECO:0000313|EMBL:CCJ30013.1};
OS   Pneumocystis jirovecii (strain SE8) (Human pneumocystis pneumonia
OS   agent).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Pneumocystidomycetes; Pneumocystidaceae; Pneumocystis.
OX   NCBI_TaxID=1209962 {ECO:0000313|Proteomes:UP000010422};
RN   [1] {ECO:0000313|EMBL:CCJ30013.1, ECO:0000313|Proteomes:UP000010422}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SE8 {ECO:0000313|EMBL:CCJ30013.1,
RC   ECO:0000313|Proteomes:UP000010422};
RX   PubMed=23269827; DOI=10.1128/mBio.00428-12;
RA   Cisse O.H., Pagni M., Hauser P.M.;
RT   "De novo assembly of the Pneumocystis jirovecii genome from a single
RT   bronchoalveolar lavage fluid specimen from a patient.";
RL   MBio 3:E428-E428(2012).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] +
CC         phosphate; Xref=Rhea:RHEA:20629, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC         COMP:11604, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:83421; EC=3.1.3.16;
CC         Evidence={ECO:0000256|SAAS:SAAS01116782};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-
CC         [protein] + phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-
CC         COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:30013, ChEBI:CHEBI:43474, ChEBI:CHEBI:61977;
CC         EC=3.1.3.16; Evidence={ECO:0000256|RuleBase:RU004273,
CC         ECO:0000256|SAAS:SAAS01116780};
CC   -!- SIMILARITY: Belongs to the PPP phosphatase family.
CC       {ECO:0000256|RuleBase:RU004273, ECO:0000256|SAAS:SAAS01017257}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:CCJ30013.1}.
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DR   EMBL; CAKM01000229; CCJ30013.1; -; Genomic_DNA.
DR   InParanoid; L0PCC5; -.
DR   Proteomes; UP000010422; Unassembled WGS sequence.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004721; F:phosphoprotein phosphatase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.60.21.10; -; 1.
DR   InterPro; IPR004843; Calcineurin-like_PHP_ApaH.
DR   InterPro; IPR029052; Metallo-depent_PP-like.
DR   InterPro; IPR006186; Ser/Thr-sp_prot-phosphatase.
DR   InterPro; IPR031675; STPPase_N.
DR   Pfam; PF00149; Metallophos; 1.
DR   Pfam; PF16891; STPPase_N; 1.
DR   PRINTS; PR00114; STPHPHTASE.
DR   SMART; SM00156; PP2Ac; 1.
DR   PROSITE; PS00125; SER_THR_PHOSPHATASE; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000010422};
KW   Hydrolase {ECO:0000256|RuleBase:RU004273,
KW   ECO:0000256|SAAS:SAAS01017252};
KW   Manganese {ECO:0000256|SAAS:SAAS01017251};
KW   Metal-binding {ECO:0000256|SAAS:SAAS01017255};
KW   Protein phosphatase {ECO:0000256|SAAS:SAAS01017274};
KW   Reference proteome {ECO:0000313|Proteomes:UP000010422}.
FT   DOMAIN      305    310       SER_THR_PHOSPHATASE.
FT                                {ECO:0000259|PROSITE:PS00125}.
SQ   SEQUENCE   515 AA;  57998 MW;  B6D6A8924D188433 CRC64;
     MGQIQSRKDD EKADAFAFFD RYDVQGSSGL FKGSLGSYRS QKNASFRGYD KEKKERLKGL
     EGMCKEVPGR TVEGLALERA SMTDRVSDKM SELELSERAA TIGASAADVF SFKNFGYNRG
     TIPSFSSLED SQQRKGAIQS KESEIDSGRY PSNASITQSS LSILQPKDTI HTKREVDTIS
     DTAASFSSLN ANGEPSNFMF FPSYLALKNL DVDDMIQRLL DAGYSGKVTK AICLKNAEVF
     AICRAAREVF LSQPSLLELT PPVKIVGDVH GQYADLIRLF EMCGFPPSAN YLFLGDYYPD
     NFFLLRGNHE CANVTRVYGF YDECKRRCNI KIWKTFVDVF NTLPIASIVA SKIFCVHGGL
     SPSLSYMDEI RQLERPTDVP DYGLLNDLLW SDPTETTNGW EDNERGVSYC FGKNVIQQFL
     QRHDFDLICR AHMVVEDGYE FFNERTLVTI FSAPNYCGEF DNFGAVMSVS EELLCSFELL
     KPLDSQQLKQ KMKRSRRNGA HIHLSPPAHQ YPQSF
//
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