ID L0RUQ0_MYCC1 Unreviewed; 549 AA.
AC L0RUQ0;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN Name=MCYN0531 {ECO:0000313|EMBL:CCP24263.1};
GN OrderedLocusNames=MCYN_0531 {ECO:0000313|EMBL:CCP24263.1};
OS Mycoplasmopsis cynos (strain C142) (Mycoplasma cynos).
OC Bacteria; Mycoplasmatota; Mycoplasmoidales; Metamycoplasmataceae;
OC Mycoplasmopsis.
OX NCBI_TaxID=1246955 {ECO:0000313|EMBL:CCP24263.1, ECO:0000313|Proteomes:UP000010466};
RN [1] {ECO:0000313|Proteomes:UP000010466}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C142 {ECO:0000313|Proteomes:UP000010466};
RX PubMed=23409256; DOI=10.1128/genomeA.00196-12;
RA Walker C.A., Mannering S.A., Shields S., Blake D.P., Brownlie J.;
RT "Complete genome sequence of Mycoplasma cynos strain C142.";
RL Genome Announc. 1:E00196-E00196(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
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DR EMBL; HF559394; CCP24263.1; -; Genomic_DNA.
DR AlphaFoldDB; L0RUQ0; -.
DR STRING; 1246955.MCYN_0531; -.
DR KEGG; mcy:MCYN_0531; -.
DR PATRIC; fig|1246955.3.peg.481; -.
DR eggNOG; COG0286; Bacteria.
DR eggNOG; COG0732; Bacteria.
DR HOGENOM; CLU_021520_0_0_14; -.
DR Proteomes; UP000010466; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0006306; P:DNA methylation; IEA:InterPro.
DR GO; GO:0009307; P:DNA restriction-modification system; IEA:UniProtKB-KW.
DR Gene3D; 3.90.220.20; DNA methylase specificity domains; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR003356; DNA_methylase_A-5.
DR InterPro; IPR044946; Restrct_endonuc_typeI_TRD_sf.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR42933:SF1; SITE-SPECIFIC DNA-METHYLTRANSFERASE (ADENINE-SPECIFIC); 1.
DR PANTHER; PTHR42933; SLR6095 PROTEIN; 1.
DR Pfam; PF02384; N6_Mtase; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Reference proteome {ECO:0000313|Proteomes:UP000010466};
KW Restriction system {ECO:0000256|ARBA:ARBA00022747};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 143..426
FT /note="DNA methylase adenine-specific"
FT /evidence="ECO:0000259|Pfam:PF02384"
SQ SEQUENCE 549 AA; 62877 MW; 957A15B9193DF859 CRC64;
MQKRISGETI SDEELIRVIK DLNKKFNLNN RVRSTDRSLF FSGLIIALTN NNFRQTFEAI
EAPSEEEVAK IDATILEAYN LNEAILTAIE KQISIKINNL SKEYVWKDKF SFIRNIDYSL
KEYKEIIKTI RDKVYIPFKN EEKQDILGKA YKLFLARGGK AEDKNIILTP DHIKELMVKL
ARLTVDDVVL DTCMGSGGFL MEAMEVITHM LKDDVQKINN VYDKQLIGFE IDSVLFALAC
SNMYLHGDGR SNLLYRSSLL HSDSNGTIVN NKDQVLYKYI KDLKPTKCII NPPYELDSPI
KFTEQALKYI EDNGKLIIIM PTPTLNKHKS DLTKNILEMA KLDFVIKMPY NLFNEQGRTV
NTSIFGFTKT PHQPDDEVLF VNLKEDGFES IQHKGRVDVN NKWNDIENKI LDIINNSKEE
NGLSTKKKIY RKKKDTVDEL ELYPTGIPTK KTGKDLVKLG DLFDFDKEEL FADETSKLQS
SKNDESGKYD FITAADDWKK HTEYSHDVEA LVYAVSAGGS LGKSQYVNGK FICSNLCTIL
TKKRVLIVR
//
