ID L1IAB4_GUITC Unreviewed; 1897 AA.
AC L1IAB4;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE RecName: Full=C2 domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=GUITHDRAFT_120654 {ECO:0000313|EMBL:EKX33173.1};
OS Guillardia theta (strain CCMP2712) (Cryptophyte).
OC Eukaryota; Cryptophyceae; Pyrenomonadales; Geminigeraceae; Guillardia.
OX NCBI_TaxID=905079 {ECO:0000313|EMBL:EKX33173.1};
RN [1] {ECO:0000313|EMBL:EKX33173.1, ECO:0000313|Proteomes:UP000011087}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CCMP2712 {ECO:0000313|EMBL:EKX33173.1,
RC ECO:0000313|Proteomes:UP000011087};
RX PubMed=23201678; DOI=10.1038/nature11681;
RG DOE Joint Genome Institute;
RA Curtis B.A., Tanifuji G., Burki F., Gruber A., Irimia M., Maruyama S.,
RA Arias M.C., Ball S.G., Gile G.H., Hirakawa Y., Hopkins J.F., Kuo A.,
RA Rensing S.A., Schmutz J., Symeonidi A., Elias M., Eveleigh R.J.,
RA Herman E.K., Klute M.J., Nakayama T., Obornik M., Reyes-Prieto A.,
RA Armbrust E.V., Aves S.J., Beiko R.G., Coutinho P., Dacks J.B.,
RA Durnford D.G., Fast N.M., Green B.R., Grisdale C.J., Hempel F.,
RA Henrissat B., Hoppner M.P., Ishida K., Kim E., Koreny L., Kroth P.G.,
RA Liu Y., Malik S.B., Maier U.G., McRose D., Mock T., Neilson J.A.,
RA Onodera N.T., Poole A.M., Pritham E.J., Richards T.A., Rocap G., Roy S.W.,
RA Sarai C., Schaack S., Shirato S., Slamovits C.H., Spencer D.F., Suzuki S.,
RA Worden A.Z., Zauner S., Barry K., Bell C., Bharti A.K., Crow J.A.,
RA Grimwood J., Kramer R., Lindquist E., Lucas S., Salamov A., McFadden G.I.,
RA Lane C.E., Keeling P.J., Gray M.W., Grigoriev I.V., Archibald J.M.;
RT "Algal genomes reveal evolutionary mosaicism and the fate of
RT nucleomorphs.";
RL Nature 492:59-65(2012).
RN [2] {ECO:0000313|Proteomes:UP000011087}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CCMP2712 {ECO:0000313|Proteomes:UP000011087};
RA Kuo A., Curtis B.A., Tanifuji G., Burki F., Gruber A., Irimia M.,
RA Maruyama S., Arias M.C., Ball S.G., Gile G.H., Hirakawa Y., Hopkins J.F.,
RA Rensing S.A., Schmutz J., Symeonidi A., Elias M., Eveleigh R.J.,
RA Herman E.K., Klute M.J., Nakayama T., Obornik M., Reyes-Prieto A.,
RA Armbrust E.V., Aves S.J., Beiko R.G., Coutinho P., Dacks J.B.,
RA Durnford D.G., Fast N.M., Green B.R., Grisdale C., Hempe F., Henrissat B.,
RA Hoppner M.P., Ishida K.-I., Kim E., Koreny L., Kroth P.G., Liu Y.,
RA Malik S.-B., Maier U.G., McRose D., Mock T., Neilson J.A., Onodera N.T.,
RA Poole A.M., Pritham E.J., Richards T.A., Rocap G., Roy S.W., Sarai C.,
RA Schaack S., Shirato S., Slamovits C.H., Spencer D.F., Suzuki S.,
RA Worden A.Z., Zauner S., Barry K., Bell C., Bharti A.K., Crow J.A.,
RA Grimwood J., Kramer R., Lindquist E., Lucas S., Salamov A., McFadden G.I.,
RA Lane C.E., Keeling P.J., Gray M.W., Grigoriev I.V., Archibald J.M.;
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblProtists:EKX33173}
RP IDENTIFICATION.
RG EnsemblProtists;
RL Submitted (MAR-2016) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; JH993153; EKX33173.1; -; Genomic_DNA.
DR RefSeq; XP_005820153.1; XM_005820096.1.
DR PaxDb; 55529-EKX33173; -.
DR EnsemblProtists; EKX33173; EKX33173; GUITHDRAFT_120654.
DR GeneID; 17289900; -.
DR KEGG; gtt:GUITHDRAFT_120654; -.
DR eggNOG; KOG3599; Eukaryota.
DR HOGENOM; CLU_246200_0_0_1; -.
DR OMA; ASWNLCP; -.
DR OrthoDB; 2968969at2759; -.
DR Proteomes; UP000011087; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR CDD; cd00030; C2; 1.
DR CDD; cd00041; CUB; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR013122; PKD1_2_channel.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR PANTHER; PTHR10877:SF183; AT14535P-RELATED; 1.
DR PANTHER; PTHR10877; POLYCYSTIN FAMILY MEMBER; 1.
DR Pfam; PF00168; C2; 1.
DR Pfam; PF00431; CUB; 1.
DR Pfam; PF08016; PKD_channel; 1.
DR SMART; SM00239; C2; 1.
DR SMART; SM00042; CUB; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF49854; Spermadhesin, CUB domain; 1.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS01180; CUB; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000011087};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1229..1245
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1272..1290
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1370..1390
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1410..1432
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1444..1464
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1476..1498
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 493..611
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1693..1812
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT REGION 421..494
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 750..779
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1841..1879
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 464..480
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1841..1857
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1897 AA; 212866 MW; E89AF66E74A19B68 CRC64;
MQGAVVASVL KKRREKKARS VEEEEIEHLI KHPVDTLVDD IHEVEGVLRD TEIHKLFGLR
SRSDPIVRRE IQIDGLLTKV REKLLRSSSY TRLFGTSIFF IVYVSFLFLQ RDIESSYYVE
SSVIDLVGSS LPLLGNGGYM NSGLGSTGFL STSEDFYSWF RGIAQVVFSD PVCGDGKCDG
PDEFPGFGRF GCIKDCGKYK NVTSLTITLE DVVKRSSSEL GISLKDSELE QDTSRVRFFY
NIYSETMGDF LFESDTNATQ LTFEAPDGDL TLVLYQESSV EGLVENQAVT SLFAITPSSF
SRLQPRKTAI EYGNLREIIK NAVYGENALK TLCRSPSESQ VAYCDTFNPQ DVGYLFTSKY
GVSGRIDLKD SVTGVLETIV KVGYCSILPN VSGSPYAQAN KATIVESGSS CDEPLRLRRS
RVRQATPRSH LPQVVPPKGT AGQDALDKHP AGSQHPPASP SSHKGKSDIE EVEGPKAKSD
KNSLRTVSNC PSTGQTLTST TGYVASGFTT TYSSNTLCTW TIAPSGNGNL TLTFQSFDVE
YHSTCRYDWV KIYSCTSVNC LDSESTLLAT LCGTMDRINP QLTSPTGIMK VSFKSDSSVQ
KAGFCASWGE GAYCPVKPDT PVFNKVEHVL RPLHNSYLYG ISIAEIQVLS TSSVSYFRYT
YSTDAQPTPR CDCADWPDTT TCPNAIKNGS KIVLFYEGAT SRRYIRVNVI ACNKYPDVTV
SSRYYRYYYN YFLGPPVVSF SFLVNFLEPP ASSSTPSNST LNKLTSSANS SNSSNSSLDN
SSTALANSST VLHPLCGNFS VDQVWREIVQ QKINVTRALP QQMRFNVTRQ DPTVYVSSEV
FATSNVQVAA IVNVLLDHRQ LMQQALARAC PLLKIQQEMA ISTSWLFNKG ARGEECKSHY
DCDAGLFCTK PSSTSLEETS TCDICSFCKV DANDAIDARC PTLMCPTSGN FPACTNAQRL
TARATCPSDY QFSVWEYRNA SEGLPKIVPP FEPKNREITP YNRIVGAIVI SQRRMKPTSC
AQSVNKHVQG FMKSVEGVVS CPSSTLDDTP YGYDPSFMTF SAMYNPKLMP EKFYSPLERH
LIRSGGETQL SFPIGFFPHK YDSNFFDTNQ DGFISDEEAS VNVSSFKVAY KDSKYIMPSE
ADTFKLYFDE RLTQMLAQNM IQFAEDGSFI DSQTEEVRVQ FLTYNAPKNI FALHEFIFNW
QTTGRIPWDY KVNSFSVDFF AGPKAGMQIF LFAVLVTFLL INSYMEVHEL LGEIRKYNLT
GYLSHPFNWI DWTHFAFMWG TIITCLLHYF DCRQFYMKAN YPILFYGPEY STAGQQRKGI
TTVQTGSSFQ VPLLKSGNAM ARHFRTDNKA EMDLLILLEQ ARTISDSMNL YSFFAGVSVV
LFVLRMLKSL DFQERMGLVT RTIARASSDL WHFMLLFAVV FYGYSVVGHM LFGHQYEGMK
DMSTACLTLL IFLLSLDTTQ FYASMSHAAP DGAFHIFLWS YLFIAFFILL NVFLAILVDA
YAKVKEETEG TTGLVEDLLE TLWHGLRKTI KARHFVSNQK LEEALVKERE TLTSKESQRR
ILERDLDEER LILLPGGVSL DTHEVAALAR RALGRKTDKV HPDAGEEEQL ADLFFNEDEI
VASADLMNRY GTEPSVISER RKSELLELHD LEGIRRQIGT QIGQVKLLGS QQQVLDLLTS
IGKELAPAAI ALQKEQEQQV QTAPAPTSVK LLRVTLVRAT NLPRMDLFSG CDPYCVLFVN
ACSGLSTFAS EVKHKNVNPV WEQQFEWTTT SRTKVLSVTL WDKDDVTSDD LVGSVQLDLE
QLPEGEEQEL TLPLQNHKLF RKLRETRLVL RVHKLTETES LKQEKTVSEK GKGPQEEEQE
EEEQEEEQKQ EQEQVEHVTQ IEDLQELDEL LENEIGQ
//
