ID L1IQT7_GUITC Unreviewed; 1097 AA.
AC L1IQT7;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 24-JAN-2024, entry version 52.
DE RecName: Full=Exportin-T {ECO:0000256|ARBA:ARBA00018928, ECO:0000256|RuleBase:RU366037};
DE AltName: Full=Exportin(tRNA) {ECO:0000256|ARBA:ARBA00029784, ECO:0000256|RuleBase:RU366037};
DE AltName: Full=tRNA exportin {ECO:0000256|ARBA:ARBA00032199, ECO:0000256|RuleBase:RU366037};
GN ORFNames=GUITHDRAFT_115409 {ECO:0000313|EMBL:EKX38442.1};
OS Guillardia theta (strain CCMP2712) (Cryptophyte).
OC Eukaryota; Cryptophyceae; Pyrenomonadales; Geminigeraceae; Guillardia.
OX NCBI_TaxID=905079 {ECO:0000313|EMBL:EKX38442.1};
RN [1] {ECO:0000313|EMBL:EKX38442.1, ECO:0000313|Proteomes:UP000011087}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CCMP2712 {ECO:0000313|EMBL:EKX38442.1,
RC ECO:0000313|Proteomes:UP000011087};
RX PubMed=23201678; DOI=10.1038/nature11681;
RG DOE Joint Genome Institute;
RA Curtis B.A., Tanifuji G., Burki F., Gruber A., Irimia M., Maruyama S.,
RA Arias M.C., Ball S.G., Gile G.H., Hirakawa Y., Hopkins J.F., Kuo A.,
RA Rensing S.A., Schmutz J., Symeonidi A., Elias M., Eveleigh R.J.,
RA Herman E.K., Klute M.J., Nakayama T., Obornik M., Reyes-Prieto A.,
RA Armbrust E.V., Aves S.J., Beiko R.G., Coutinho P., Dacks J.B.,
RA Durnford D.G., Fast N.M., Green B.R., Grisdale C.J., Hempel F.,
RA Henrissat B., Hoppner M.P., Ishida K., Kim E., Koreny L., Kroth P.G.,
RA Liu Y., Malik S.B., Maier U.G., McRose D., Mock T., Neilson J.A.,
RA Onodera N.T., Poole A.M., Pritham E.J., Richards T.A., Rocap G., Roy S.W.,
RA Sarai C., Schaack S., Shirato S., Slamovits C.H., Spencer D.F., Suzuki S.,
RA Worden A.Z., Zauner S., Barry K., Bell C., Bharti A.K., Crow J.A.,
RA Grimwood J., Kramer R., Lindquist E., Lucas S., Salamov A., McFadden G.I.,
RA Lane C.E., Keeling P.J., Gray M.W., Grigoriev I.V., Archibald J.M.;
RT "Algal genomes reveal evolutionary mosaicism and the fate of
RT nucleomorphs.";
RL Nature 492:59-65(2012).
RN [2] {ECO:0000313|Proteomes:UP000011087}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CCMP2712 {ECO:0000313|Proteomes:UP000011087};
RA Kuo A., Curtis B.A., Tanifuji G., Burki F., Gruber A., Irimia M.,
RA Maruyama S., Arias M.C., Ball S.G., Gile G.H., Hirakawa Y., Hopkins J.F.,
RA Rensing S.A., Schmutz J., Symeonidi A., Elias M., Eveleigh R.J.,
RA Herman E.K., Klute M.J., Nakayama T., Obornik M., Reyes-Prieto A.,
RA Armbrust E.V., Aves S.J., Beiko R.G., Coutinho P., Dacks J.B.,
RA Durnford D.G., Fast N.M., Green B.R., Grisdale C., Hempe F., Henrissat B.,
RA Hoppner M.P., Ishida K.-I., Kim E., Koreny L., Kroth P.G., Liu Y.,
RA Malik S.-B., Maier U.G., McRose D., Mock T., Neilson J.A., Onodera N.T.,
RA Poole A.M., Pritham E.J., Richards T.A., Rocap G., Roy S.W., Sarai C.,
RA Schaack S., Shirato S., Slamovits C.H., Spencer D.F., Suzuki S.,
RA Worden A.Z., Zauner S., Barry K., Bell C., Bharti A.K., Crow J.A.,
RA Grimwood J., Kramer R., Lindquist E., Lucas S., Salamov A., McFadden G.I.,
RA Lane C.E., Keeling P.J., Gray M.W., Grigoriev I.V., Archibald J.M.;
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblProtists:EKX38442}
RP IDENTIFICATION.
RG EnsemblProtists;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- FUNCTION: tRNA nucleus export receptor which facilitates tRNA
CC translocation across the nuclear pore complex.
CC {ECO:0000256|RuleBase:RU366037}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC ECO:0000256|RuleBase:RU366037}. Nucleus
CC {ECO:0000256|RuleBase:RU366037}. Note=Shuttles between the nucleus and
CC the cytoplasm. {ECO:0000256|RuleBase:RU366037}.
CC -!- SIMILARITY: Belongs to the exportin family.
CC {ECO:0000256|RuleBase:RU366037}.
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DR EMBL; JH993048; EKX38442.1; -; Genomic_DNA.
DR RefSeq; XP_005825422.1; XM_005825365.1.
DR AlphaFoldDB; L1IQT7; -.
DR STRING; 905079.L1IQT7; -.
DR PaxDb; 55529-EKX38442; -.
DR EnsemblProtists; EKX38442; EKX38442; GUITHDRAFT_115409.
DR GeneID; 17295206; -.
DR KEGG; gtt:GUITHDRAFT_115409; -.
DR eggNOG; KOG2021; Eukaryota.
DR HOGENOM; CLU_283788_0_0_1; -.
DR OMA; HEMFLFG; -.
DR OrthoDB; 2546268at2759; -.
DR Proteomes; UP000011087; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0000049; F:tRNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0071528; P:tRNA re-export from nucleus; IEA:UniProtKB-UniRule.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR013598; Exportin-1/Importin-b-like.
DR InterPro; IPR045546; Exportin-T_C.
DR InterPro; IPR040017; XPOT.
DR PANTHER; PTHR15952:SF11; EXPORTIN-T; 1.
DR PANTHER; PTHR15952; EXPORTIN-T/LOS1; 1.
DR Pfam; PF19282; Exportin-T; 2.
DR Pfam; PF08389; Xpo1; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|RuleBase:RU366037};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU366037};
KW Reference proteome {ECO:0000313|Proteomes:UP000011087};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|RuleBase:RU366037};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|RuleBase:RU366037};
KW tRNA-binding {ECO:0000256|ARBA:ARBA00022555,
KW ECO:0000256|RuleBase:RU366037}.
FT TRANSMEM 749..774
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 103..252
FT /note="Exportin-1/Importin-beta-like"
FT /evidence="ECO:0000259|Pfam:PF08389"
FT DOMAIN 327..642
FT /note="Exportin-T C-terminal"
FT /evidence="ECO:0000259|Pfam:PF19282"
FT DOMAIN 837..1092
FT /note="Exportin-T C-terminal"
FT /evidence="ECO:0000259|Pfam:PF19282"
SQ SEQUENCE 1097 AA; 122931 MW; ED6786D1792F9E2B CRC64;
MTNQYEDAEK AVLCIYDQSS DAALRKQAQD YCDGLKNSDG ALHLACGLMM RSSAQQVKFW
CLQVLEEVLQ HRYATLSDQD RGEVKKFLVS WILETCPAGP PQPPFLLNKV AQIYAILVRN
DYPEQWPEAL TSLLAALNSG VAVIDMFLRV QDAVDAEIIN SEFHRSPADA AVSMRVKDAL
RVQCLNEMAS AWYIILREFY QSEPGLVKSC LSSISRYIHW IDIGLIMNDK FVPAFYALLE
NDVFIEEAAM CLTEMVLKKM EPVPKIHHIN SLINKPLIEN ALAVRARGAS KSSAALVRLA
HLTGSICKEL LVCADKISAA SPAEALQAQA QLQELMPLAL GCAMNENDDV SSASMEFVTI
FVNSLKKLDP LPEFHLKQLS GVLAVLLRKL RYSSDFDFQN PGESEEFWLE YRKEVLIIFK
NISRIAPDLT VSFVQDCMNG LIAETTNGTP NNWPEIEAVL TMLYELGEVS RVEDACKSTD
QGMGKLLSIV LSSNIALHPH PCVQKVYLEI ANRYSQFLHK HSHLLPQVLM GFVQAVTNSR
SSVKSRACYL FLRVLKSLKP RLGPHADALM SSVVPVLLDQ QQSVALDHMD RLYLFEATGN
VLGSDSLPLE QAVMYLHQIV TPILQRMSEV AMEFLRTSEQ SVMVANSVTS DDVWLRVGVP
LECLGWLSKG CTRLCSNENA LFRQALEVSV GVIARVPYNM GRLQSSTLLF LHRMVDCLGE
RLRLKGMMMF QFVKRALQKL VCIILQNKII IIAIIIVDVI IVLIILSIFV FVFFSNFYIV
PIIITTTTTT TTKHHIQHSY HSCLFRCCRV MSIISNASHH VDTIVISTTM VLVIIECGTG
MLSFLPSSIG SMLKNIEVKG MTEVTTLINQ VMSRFKEDCN GHIDVVLESL SDRILSSFQS
LPNLCVSNPS QEAREFRDLY KIWLQLLQTA GLSNLIDIFL RIRSGQLVEP VVRSVVDGLT
RIDEPSTNKV CIGILYRMVQ RWGANGEGAA QEQLTGFSDF FLPVVARALF SSAAPAASNA
NDAQCHAFLS EIASFQRNLR MAYGVRWEET LRREGLVGCC GMEEEAAKLY VWNMQQLSDR
DFREFFIQQV QNLIVRG
//
