ID L1IYB2_GUITC Unreviewed; 664 AA.
AC L1IYB2;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE RecName: Full=DNA-directed DNA polymerase family A palm domain-containing protein {ECO:0000259|SMART:SM00482};
DE Flags: Fragment;
GN ORFNames=GUITHDRAFT_74910 {ECO:0000313|EMBL:EKX41231.1};
OS Guillardia theta (strain CCMP2712) (Cryptophyte).
OC Eukaryota; Cryptophyceae; Pyrenomonadales; Geminigeraceae; Guillardia.
OX NCBI_TaxID=905079 {ECO:0000313|EMBL:EKX41231.1};
RN [1] {ECO:0000313|EMBL:EKX41231.1, ECO:0000313|Proteomes:UP000011087}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CCMP2712 {ECO:0000313|EMBL:EKX41231.1,
RC ECO:0000313|Proteomes:UP000011087};
RX PubMed=23201678; DOI=10.1038/nature11681;
RG DOE Joint Genome Institute;
RA Curtis B.A., Tanifuji G., Burki F., Gruber A., Irimia M., Maruyama S.,
RA Arias M.C., Ball S.G., Gile G.H., Hirakawa Y., Hopkins J.F., Kuo A.,
RA Rensing S.A., Schmutz J., Symeonidi A., Elias M., Eveleigh R.J.,
RA Herman E.K., Klute M.J., Nakayama T., Obornik M., Reyes-Prieto A.,
RA Armbrust E.V., Aves S.J., Beiko R.G., Coutinho P., Dacks J.B.,
RA Durnford D.G., Fast N.M., Green B.R., Grisdale C.J., Hempel F.,
RA Henrissat B., Hoppner M.P., Ishida K., Kim E., Koreny L., Kroth P.G.,
RA Liu Y., Malik S.B., Maier U.G., McRose D., Mock T., Neilson J.A.,
RA Onodera N.T., Poole A.M., Pritham E.J., Richards T.A., Rocap G., Roy S.W.,
RA Sarai C., Schaack S., Shirato S., Slamovits C.H., Spencer D.F., Suzuki S.,
RA Worden A.Z., Zauner S., Barry K., Bell C., Bharti A.K., Crow J.A.,
RA Grimwood J., Kramer R., Lindquist E., Lucas S., Salamov A., McFadden G.I.,
RA Lane C.E., Keeling P.J., Gray M.W., Grigoriev I.V., Archibald J.M.;
RT "Algal genomes reveal evolutionary mosaicism and the fate of
RT nucleomorphs.";
RL Nature 492:59-65(2012).
RN [2] {ECO:0000313|Proteomes:UP000011087}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CCMP2712 {ECO:0000313|Proteomes:UP000011087};
RA Kuo A., Curtis B.A., Tanifuji G., Burki F., Gruber A., Irimia M.,
RA Maruyama S., Arias M.C., Ball S.G., Gile G.H., Hirakawa Y., Hopkins J.F.,
RA Rensing S.A., Schmutz J., Symeonidi A., Elias M., Eveleigh R.J.,
RA Herman E.K., Klute M.J., Nakayama T., Obornik M., Reyes-Prieto A.,
RA Armbrust E.V., Aves S.J., Beiko R.G., Coutinho P., Dacks J.B.,
RA Durnford D.G., Fast N.M., Green B.R., Grisdale C., Hempe F., Henrissat B.,
RA Hoppner M.P., Ishida K.-I., Kim E., Koreny L., Kroth P.G., Liu Y.,
RA Malik S.-B., Maier U.G., McRose D., Mock T., Neilson J.A., Onodera N.T.,
RA Poole A.M., Pritham E.J., Richards T.A., Rocap G., Roy S.W., Sarai C.,
RA Schaack S., Shirato S., Slamovits C.H., Spencer D.F., Suzuki S.,
RA Worden A.Z., Zauner S., Barry K., Bell C., Bharti A.K., Crow J.A.,
RA Grimwood J., Kramer R., Lindquist E., Lucas S., Salamov A., McFadden G.I.,
RA Lane C.E., Keeling P.J., Gray M.W., Grigoriev I.V., Archibald J.M.;
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblProtists:EKX41231}
RP IDENTIFICATION.
RG EnsemblProtists;
RL Submitted (JUN-2015) to UniProtKB.
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DR EMBL; JH993025; EKX41231.1; -; Genomic_DNA.
DR RefSeq; XP_005828211.1; XM_005828154.1.
DR AlphaFoldDB; L1IYB2; -.
DR STRING; 905079.L1IYB2; -.
DR PaxDb; 55529-EKX41231; -.
DR EnsemblProtists; EKX41231; EKX41231; GUITHDRAFT_74910.
DR GeneID; 17297834; -.
DR KEGG; gtt:GUITHDRAFT_74910; -.
DR eggNOG; KOG0950; Eukaryota.
DR HOGENOM; CLU_004638_2_1_1; -.
DR OMA; LASCKSM; -.
DR OrthoDB; 208079at2759; -.
DR Proteomes; UP000011087; Unassembled WGS sequence.
DR GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:InterPro.
DR GO; GO:0006261; P:DNA-templated DNA replication; IEA:InterPro.
DR CDD; cd08640; DNA_pol_A_plastid_like; 1.
DR Gene3D; 3.30.70.370; -; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR002562; 3'-5'_exonuclease_dom.
DR InterPro; IPR001098; DNA-dir_DNA_pol_A_palm_dom.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR002298; DNA_polymerase_A.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR PANTHER; PTHR10133; DNA POLYMERASE I; 1.
DR PANTHER; PTHR10133:SF27; DNA-DIRECTED DNA POLYMERASE; 1.
DR Pfam; PF00476; DNA_pol_A; 2.
DR Pfam; PF01612; DNA_pol_A_exo1; 1.
DR PRINTS; PR00868; DNAPOLI.
DR SMART; SM00482; POLAc; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000011087}.
FT DOMAIN 398..626
FT /note="DNA-directed DNA polymerase family A palm"
FT /evidence="ECO:0000259|SMART:SM00482"
FT REGION 228..266
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 232..249
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 250..264
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EKX41231.1"
SQ SEQUENCE 664 AA; 75849 MW; 651CF4A2FD509625 CRC64;
LQIFHNWSFD GHLLANHGIE ILGHRSGDTV HMARLWDTSR QGRGGYKLSS LMQDLLGWGK
TDMKEVFGRF KLKKDGTPGK VVYLPDSLTL QTDPNVTMFE KWIHYSTYDT ICTWYLYFSL
RKELENMSWS PDAIVYENEL LKMRADRTLF TFYDCFWRPF GQILTDMERK GMYIDKDYLY
QQAEKAQEDK EKRTESFMQW VRSLCPDGKY ININSNPQKR HLLFSSITEP DDAGSREPHM
RTFQVDNKVE EEEEREEEEG EEGEVLFLSP PRSKRSISLL GLALTPVAYT ATGQASTAGQ
VIQKLAGKPF ASPPSYGTAF KDLGGGEEGK AACEALASLL EGEAIEKLLS TFLLPLPEQT
DEASRIHTSL NINTETGRLS SQRPNLQNQP ALEKDVYRMR KAFSAPPGRK LIIVDYGQLE
LRIMAQMTGC RSMLDAFEQG GDFHSRTAID MYRYIAEAVE RKEVLLEWNS HDGAPPAPML
KDKFASERRK AKTLNFGIAY GMTKMKVARD WGVSLEEAEE TIQTWYSARK EVKQWQEEVI
ERARRTGYTE TFLGRRRYLP EINGRDGVGR GHAERAAINT PIQGGAADIV MMAMLKLRGE
ERIRRLGWRM VMQIHDEIIL EGPEETAEEV FPLVRACMEQ PFDSPLSVEL PVDGSIADNW
YEGK
//
