ID L1JSD6_GUITC Unreviewed; 986 AA.
AC L1JSD6;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=Polycystin cation channel PKD1/PKD2 domain-containing protein {ECO:0000259|Pfam:PF08016};
GN ORFNames=GUITHDRAFT_103580 {ECO:0000313|EMBL:EKX50993.1};
OS Guillardia theta (strain CCMP2712) (Cryptophyte).
OC Eukaryota; Cryptophyceae; Pyrenomonadales; Geminigeraceae; Guillardia.
OX NCBI_TaxID=905079 {ECO:0000313|EMBL:EKX50993.1};
RN [1] {ECO:0000313|EMBL:EKX50993.1, ECO:0000313|Proteomes:UP000011087}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CCMP2712 {ECO:0000313|EMBL:EKX50993.1,
RC ECO:0000313|Proteomes:UP000011087};
RX PubMed=23201678; DOI=10.1038/nature11681;
RG DOE Joint Genome Institute;
RA Curtis B.A., Tanifuji G., Burki F., Gruber A., Irimia M., Maruyama S.,
RA Arias M.C., Ball S.G., Gile G.H., Hirakawa Y., Hopkins J.F., Kuo A.,
RA Rensing S.A., Schmutz J., Symeonidi A., Elias M., Eveleigh R.J.,
RA Herman E.K., Klute M.J., Nakayama T., Obornik M., Reyes-Prieto A.,
RA Armbrust E.V., Aves S.J., Beiko R.G., Coutinho P., Dacks J.B.,
RA Durnford D.G., Fast N.M., Green B.R., Grisdale C.J., Hempel F.,
RA Henrissat B., Hoppner M.P., Ishida K., Kim E., Koreny L., Kroth P.G.,
RA Liu Y., Malik S.B., Maier U.G., McRose D., Mock T., Neilson J.A.,
RA Onodera N.T., Poole A.M., Pritham E.J., Richards T.A., Rocap G., Roy S.W.,
RA Sarai C., Schaack S., Shirato S., Slamovits C.H., Spencer D.F., Suzuki S.,
RA Worden A.Z., Zauner S., Barry K., Bell C., Bharti A.K., Crow J.A.,
RA Grimwood J., Kramer R., Lindquist E., Lucas S., Salamov A., McFadden G.I.,
RA Lane C.E., Keeling P.J., Gray M.W., Grigoriev I.V., Archibald J.M.;
RT "Algal genomes reveal evolutionary mosaicism and the fate of
RT nucleomorphs.";
RL Nature 492:59-65(2012).
RN [2] {ECO:0000313|Proteomes:UP000011087}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CCMP2712 {ECO:0000313|Proteomes:UP000011087};
RA Kuo A., Curtis B.A., Tanifuji G., Burki F., Gruber A., Irimia M.,
RA Maruyama S., Arias M.C., Ball S.G., Gile G.H., Hirakawa Y., Hopkins J.F.,
RA Rensing S.A., Schmutz J., Symeonidi A., Elias M., Eveleigh R.J.,
RA Herman E.K., Klute M.J., Nakayama T., Obornik M., Reyes-Prieto A.,
RA Armbrust E.V., Aves S.J., Beiko R.G., Coutinho P., Dacks J.B.,
RA Durnford D.G., Fast N.M., Green B.R., Grisdale C., Hempe F., Henrissat B.,
RA Hoppner M.P., Ishida K.-I., Kim E., Koreny L., Kroth P.G., Liu Y.,
RA Malik S.-B., Maier U.G., McRose D., Mock T., Neilson J.A., Onodera N.T.,
RA Poole A.M., Pritham E.J., Richards T.A., Rocap G., Roy S.W., Sarai C.,
RA Schaack S., Shirato S., Slamovits C.H., Spencer D.F., Suzuki S.,
RA Worden A.Z., Zauner S., Barry K., Bell C., Bharti A.K., Crow J.A.,
RA Grimwood J., Kramer R., Lindquist E., Lucas S., Salamov A., McFadden G.I.,
RA Lane C.E., Keeling P.J., Gray M.W., Grigoriev I.V., Archibald J.M.;
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblProtists:EKX50993}
RP IDENTIFICATION.
RG EnsemblProtists;
RL Submitted (MAR-2016) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; JH992977; EKX50993.1; -; Genomic_DNA.
DR RefSeq; XP_005837973.1; XM_005837916.1.
DR AlphaFoldDB; L1JSD6; -.
DR PaxDb; 55529-EKX50993; -.
DR EnsemblProtists; EKX50993; EKX50993; GUITHDRAFT_103580.
DR GeneID; 17307641; -.
DR KEGG; gtt:GUITHDRAFT_103580; -.
DR eggNOG; KOG3599; Eukaryota.
DR HOGENOM; CLU_295856_0_0_1; -.
DR Proteomes; UP000011087; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR Gene3D; 1.10.287.70; -; 1.
DR InterPro; IPR013122; PKD1_2_channel.
DR PANTHER; PTHR10877:SF183; AT14535P-RELATED; 1.
DR PANTHER; PTHR10877; POLYCYSTIN FAMILY MEMBER; 1.
DR Pfam; PF08016; PKD_channel; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000011087};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 55..74
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 356..374
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 400..424
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 436..462
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 488..510
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 554..579
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 599..617
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 399..580
FT /note="Polycystin cation channel PKD1/PKD2"
FT /evidence="ECO:0000259|Pfam:PF08016"
SQ SEQUENCE 986 AA; 114060 MW; 2B0E804C754852B2 CRC64;
MSAQASLAYS IPPFGINPPK PFATENKVVN EREQYIPLLQ FMNVLSSSTR FRHGVFRLCF
YLVYAATFIF IMVLEVTNGF GPPHCGGTGQ CLPYSVWDQH LYMQSIKDSL YETSWDPANL
VNNIYDMQTF DDLKSWITKV YVPTLWPSNG NATIPYYGRV PVDPIVVKFS VRQENLCSDN
QGFDFSNKRC LGHLRTQSFG PPEDSERWRQ SNQDAAQPGY YALLAWRDRF FTKAVKKVSA
DGYVSYHVPL YNPGFSPRFG NLSQVRVWNV STAEQALNFF AMAETDGLFT HKTSSLSMWT
TFYFPTTDIT TVVRSVFEIH DSGRASICED TWLCADYGAL IWTRDFRRMY SSGNGIARLV
LEIVFLTLTL IQLFRELRQF YYSPVIMGSR SAYVLGTGGF WNFLDLICFM FIAPIYFLKI
LMYVTSSEDP ESPQRFWAAS LPVVLWSFHS GLTGWLQLFL IFRFFKYLEF SNALGIVGDT
FQKAAKDLVI FLFVFFLVIV AYSYAGYYFY RGRMYEFSTV PKSVNTVFSI MFGQVDFQSF
GFNTDTSLGS FSIAFLWSIT ILVYLILINM FLAIILSAFD MIREDLKRYR LERLQGNKYV
PPGMTILEFF LPLLTIARSM RKIKRVYSHF RQYGFELGFL STEFFPEGMV MRMLLDAQIM
SARRPPLISR VLGYNSSRQE FLIEWKGDKT WWSTHPKLMS YQPVWLSKAE IMAIKESSHS
DRSEILEIDS DKLISWESRY ILTRRVLTRQ AKDDLKRLVN VPDIYDDTFW TRGNANLIAY
SVNMDPDYLE TKHYYLAGER TRTSQDERER LRMKLETGNK LTVNELEALF IKHLMPTAAR
QKIEEKLQED RDGLNQMLSN NFLHFRIKRL VEAISESGSE VNECGLTSEE ATELIDESKQ
WTRTIFNKFG TRRHISDFPN SLGALGIEEY ERNANDENYQ FAYSLGGDDD LTDISLKQVM
KGIKKLQQQM KELSSGPKLA ATQQSN
//
