ID L1KWB8_9ACTN Unreviewed; 345 AA.
AC L1KWB8;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 24-JAN-2024, entry version 35.
DE SubName: Full=2-oxo acid dehydrogenase acyltransferase (Catalytic domain) {ECO:0000313|EMBL:EKX64824.1};
DE Flags: Fragment;
GN ORFNames=STRIP9103_02410 {ECO:0000313|EMBL:EKX64824.1};
OS Streptomyces ipomoeae 91-03.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=698759 {ECO:0000313|EMBL:EKX64824.1, ECO:0000313|Proteomes:UP000010411};
RN [1] {ECO:0000313|EMBL:EKX64824.1, ECO:0000313|Proteomes:UP000010411}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=91-03 {ECO:0000313|EMBL:EKX64824.1,
RC ECO:0000313|Proteomes:UP000010411};
RA Huguet-Tapia J.C., Durkin A.S., Pettis G.S., Badger J.H.;
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=(R)-lipoate; Xref=ChEBI:CHEBI:83088;
CC Evidence={ECO:0000256|ARBA:ARBA00001938};
CC -!- SIMILARITY: Belongs to the 2-oxoacid dehydrogenase family.
CC {ECO:0000256|ARBA:ARBA00007317}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EKX64824.1}.
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DR EMBL; AEJC01000339; EKX64824.1; -; Genomic_DNA.
DR RefSeq; WP_009318428.1; NZ_AEJC01000339.1.
DR AlphaFoldDB; L1KWB8; -.
DR PATRIC; fig|698759.3.peg.4534; -.
DR OrthoDB; 9805770at2; -.
DR Proteomes; UP000010411; Unassembled WGS sequence.
DR GO; GO:0016746; F:acyltransferase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 1.
DR Gene3D; 4.10.320.10; E3-binding domain; 1.
DR InterPro; IPR001078; 2-oxoacid_DH_actylTfrase.
DR InterPro; IPR014276; 2-oxoglutarate_DH_E2.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR036625; E3-bd_dom_sf.
DR InterPro; IPR004167; PSBD.
DR NCBIfam; TIGR02927; SucB_Actino; 1.
DR PANTHER; PTHR43178; DIHYDROLIPOAMIDE ACETYLTRANSFERASE COMPONENT OF PYRUVATE DEHYDROGENASE COMPLEX; 1.
DR PANTHER; PTHR43178:SF5; LIPOAMIDE ACYLTRANSFERASE COMPONENT OF BRANCHED-CHAIN ALPHA-KETO ACID DEHYDROGENASE COMPLEX, MITOCHONDRIAL; 1.
DR Pfam; PF00198; 2-oxoacid_dh; 1.
DR Pfam; PF02817; E3_binding; 1.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 1.
DR SUPFAM; SSF47005; Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex; 1.
DR PROSITE; PS51826; PSBD; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000313|EMBL:EKX64824.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000010411};
KW Transferase {ECO:0000313|EMBL:EKX64824.1}.
FT DOMAIN 37..74
FT /note="Peripheral subunit-binding (PSBD)"
FT /evidence="ECO:0000259|PROSITE:PS51826"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EKX64824.1"
SQ SEQUENCE 345 AA; 35205 MW; 9E9B73859802F72B CRC64;
AAAPAAPAPA PAPVTPAPAA AAPVAPAAAQ ATDEGAYVTP LVRKLAAENG VDLATVKGTG
VGGRIRKQDV IAAAEAAKAA AAAPAPAAAA PAAAAAKKAP KLEVSPLRGQ TVKMPRIRKV
IGDNMVKALH EQAQLSSVVE VDITRLMKLR AQAKDSFAAR EGVKLSPMPF FVKAAAQALK
AHPVINARIN EADGTITYFD TENIGIAVDS EKGLMTPVIK GAGDLNIAGI AKATADLAGK
VRGNKITPDE LAGATFTISN TGSRGALFDT IIVPPNQVAI LGIGATVKRP AVIETEEGTV
IGVRDMTYLT LSYDHRLVDG ADAARYLTAV KAILEAGEFE VELGL
//
