ID   L1L551_9ACTN            Unreviewed;       687 AA.
AC   L1L551;
DT   06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT   06-MAR-2013, sequence version 1.
DT   27-MAR-2024, entry version 30.
DE   SubName: Full=MMPL family protein {ECO:0000313|EMBL:EKX67919.1};
GN   ORFNames=STRIP9103_03000 {ECO:0000313|EMBL:EKX67919.1};
OS   Streptomyces ipomoeae 91-03.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=698759 {ECO:0000313|EMBL:EKX67919.1, ECO:0000313|Proteomes:UP000010411};
RN   [1] {ECO:0000313|EMBL:EKX67919.1, ECO:0000313|Proteomes:UP000010411}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=91-03 {ECO:0000313|EMBL:EKX67919.1,
RC   ECO:0000313|Proteomes:UP000010411};
RA   Huguet-Tapia J.C., Durkin A.S., Pettis G.S., Badger J.H.;
RL   Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC       (TC 2.A.6) family. MmpL subfamily. {ECO:0000256|ARBA:ARBA00010157}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EKX67919.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AEJC01000113; EKX67919.1; -; Genomic_DNA.
DR   AlphaFoldDB; L1L551; -.
DR   PATRIC; fig|698759.3.peg.1560; -.
DR   Proteomes; UP000010411; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR   InterPro; IPR004869; MMPL_dom.
DR   InterPro; IPR000731; SSD.
DR   PANTHER; PTHR33406; MEMBRANE PROTEIN MJ1562-RELATED; 1.
DR   PANTHER; PTHR33406:SF6; MEMBRANE PROTEIN SCO0839-RELATED; 1.
DR   Pfam; PF03176; MMPL; 2.
DR   SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR   PROSITE; PS50156; SSD; 1.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000010411};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        160..180
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        187..207
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        219..239
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        259..284
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        296..318
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        353..371
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        493..511
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        518..539
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        551..570
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        599..619
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        625..644
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          198..317
FT                   /note="SSD"
FT                   /evidence="ECO:0000259|PROSITE:PS50156"
FT   REGION          74..98
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          664..687
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   687 AA;  71827 MW;  86F883FAECCBCD14 CRC64;
     MCRGWCWGCG WCCWAWWGRS PPSCRRCSTT GRWIICRPVP IRRGWRRSRS SCPGARRPSW
     CLCITGTVGS VPPIGRPPPL RSPRSGSGIG WSPSRGGVPA EDGATLMYPV ASNGPGTDEK
     LRDAFVERVR EVARSRGGLT VEVGGPGALA ADAGKVYESL GGPLLYTTVG VVAVLLILIY
     RSPVLWLVPL VVAGVADFLS MGVAYGLNQA FGTSVSGQSS AMMTILVFGA GTDYALLLVS
     RYREELRRVE RPYEAMKVAL RGCGPAVLAS SGTVAAGLLC LLAADLNSSR GMGPLGMVGV
     LCALLAMLTL LPATLVLLGR RVFWPLVPAY GSEPKARRSL FSAMGSSAGR RPLTVLAGGA
     VLLGALALGT LDLPGSLKQE DSFVDRPESV AAMRTLAEAF PGQGTQPISV ITPAGRTEAT
     IAGIQGHEGV AAVERGRTGD GWTELSVIAK GAPQSAAETA TIESLRDRLP ESYIGGPSAE
     QLDLKDTNAR DRLVVVPIVL LSVLLILVAL LRSLVAPLLL VVAVVAVWAA SLGIGGLVFG
     PVFGFEGTDP GLGLLSFVFL VALGVDYGIF LMHRMREESL AGAEPAAAAL TALRTTGGVI
     ASAGLVLAAT FAVLLNMGLV QLVELGFVIA VGVLLDTFLV RTYLVTSASV ALGRKVWWPG
     RLSREPAGPV EQPPGETPPS RERVAVG
//