ID L1L7D0_9ACTN Unreviewed; 636 AA.
AC L1L7D0;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 24-JAN-2024, entry version 31.
DE SubName: Full=DNA-directed DNA polymerase {ECO:0000313|EMBL:EKX68709.1};
DE EC=2.7.7.7 {ECO:0000313|EMBL:EKX68709.1};
GN Name=polA_1 {ECO:0000313|EMBL:EKX68709.1};
GN ORFNames=STRIP9103_05615 {ECO:0000313|EMBL:EKX68709.1};
OS Streptomyces ipomoeae 91-03.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=698759 {ECO:0000313|EMBL:EKX68709.1, ECO:0000313|Proteomes:UP000010411};
RN [1] {ECO:0000313|EMBL:EKX68709.1, ECO:0000313|Proteomes:UP000010411}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=91-03 {ECO:0000313|EMBL:EKX68709.1,
RC ECO:0000313|Proteomes:UP000010411};
RA Huguet-Tapia J.C., Durkin A.S., Pettis G.S., Badger J.H.;
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EKX68709.1}.
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DR EMBL; AEJC01000061; EKX68709.1; -; Genomic_DNA.
DR AlphaFoldDB; L1L7D0; -.
DR PATRIC; fig|698759.3.peg.757; -.
DR Proteomes; UP000010411; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0006974; P:DNA damage response; IEA:UniProt.
DR GO; GO:0006261; P:DNA-templated DNA replication; IEA:InterPro.
DR CDD; cd06444; DNA_pol_A; 1.
DR Gene3D; 3.30.70.370; -; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR InterPro; IPR001098; DNA-dir_DNA_pol_A_palm_dom.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR002298; DNA_polymerase_A.
DR PANTHER; PTHR10133; DNA POLYMERASE I; 1.
DR PANTHER; PTHR10133:SF27; DNA POLYMERASE NU; 1.
DR Pfam; PF00476; DNA_pol_A; 1.
DR PRINTS; PR00868; DNAPOLI.
DR SMART; SM00482; POLAc; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
PE 4: Predicted;
KW DNA-directed DNA polymerase {ECO:0000313|EMBL:EKX68709.1};
KW Nucleotidyltransferase {ECO:0000313|EMBL:EKX68709.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000010411};
KW Transferase {ECO:0000313|EMBL:EKX68709.1}.
FT DOMAIN 378..595
FT /note="DNA-directed DNA polymerase family A palm"
FT /evidence="ECO:0000259|SMART:SM00482"
FT REGION 498..530
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 636 AA; 69229 MW; 25A59D566D22B066 CRC64;
MIKLGHREPT STRSSTQLFI RQVVCVSRSD RCRAHRERSG SAGGTAPVSY EAPWSGAVVR
PPWQTRPMTD RWALVSAEDG GVEVAPLGAA GLPAGPAEWE PDAAAAVRRR PGVGRWVWRA
TAEVYPALLA AGVRVERCYD IEVAETLLLG HEGRLGEPRS AAAALARLRH TPVPPDPPLR
TAGPAAQPSL FEPRPVHVPL TDLIEVHADQ QRRHDATVHP ERMRLLTAAE SAGMLVAAEM
NRAGLPWRAD VHREVLHELL GERYAGGGEP HRLAELADEV SNAFGRRVRP DLPADVVKAF
ARAGIRIRST RRWEIESIDH PAVKPLLEYK RLYRIWVAHG WSWLQDWVRE GRFRPEFLAG
GTVTGRWVTN GGGALQIPKV IRRACVADPG WRLVVADADQ MEPRVLAAIS RDPGLMEVAG
RDTDLYQSVS DRAFSGDRAQ AKLAVLGAVY GQTSGDGLKN LAALRRRFPK AVQYVDDAAR
AGEEGRLVRT WLGRTCPPAA GSSDDAATEE AGIPQADQDV PADREGGQGN EWVPGYASAN
SRARGRFARN FVVQGSAADW TLLLLAALRR ALAGMAAELV FFQHDEVIVH CPAEEADAVV
AAIREASDLS ARLTFGETPV RLPFTTAVVE CYADAK
//