ID L1NHS0_9NEIS Unreviewed; 827 AA.
AC L1NHS0;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE SubName: Full=CRISPR-associated endonuclease Cas3-HD {ECO:0000313|EMBL:EKY02928.1};
GN ORFNames=HMPREF9120_02825 {ECO:0000313|EMBL:EKY02928.1};
OS Neisseria sp. oral taxon 020 str. F0370.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Neisseriales; Neisseriaceae;
OC Neisseria.
OX NCBI_TaxID=1127694 {ECO:0000313|EMBL:EKY02928.1, ECO:0000313|Proteomes:UP000010457};
RN [1] {ECO:0000313|EMBL:EKY02928.1, ECO:0000313|Proteomes:UP000010457}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=F0370 {ECO:0000313|EMBL:EKY02928.1,
RC ECO:0000313|Proteomes:UP000010457};
RA Weinstock G., Sodergren E., Lobos E.A., Fulton L., Fulton R., Courtney L.,
RA Fronick C., O'Laughlin M., Godfrey J., Wilson R.M., Miner T., Farmer C.,
RA Delehaunty K., Cordes M., Minx P., Tomlinson C., Chen J., Wollam A.,
RA Pepin K.H., Bhonagiri V., Zhang X., Suruliraj S., Warren W., Mitreva M.,
RA Mardis E.R., Wilson R.K.;
RL Submitted (MAY-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: In the N-terminal section; belongs to the CRISPR-associated
CC nuclease Cas3-HD family. {ECO:0000256|ARBA:ARBA00006847}.
CC -!- SIMILARITY: In the central section; belongs to the CRISPR-associated
CC helicase Cas3 family. {ECO:0000256|ARBA:ARBA00009046}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EKY02928.1}.
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DR EMBL; AMER01000216; EKY02928.1; -; Genomic_DNA.
DR RefSeq; WP_009427624.1; NZ_KB291165.1.
DR AlphaFoldDB; L1NHS0; -.
DR STRING; 1127694.HMPREF9120_02825; -.
DR PATRIC; fig|1127694.3.peg.2621; -.
DR HOGENOM; CLU_010123_0_0_4; -.
DR OrthoDB; 9810236at2; -.
DR Proteomes; UP000010457; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
DR CDD; cd09641; Cas3''_I; 1.
DR CDD; cd17930; DEXHc_cas3; 1.
DR Gene3D; 1.10.3210.30; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR006483; CRISPR-assoc_Cas3_HD.
DR InterPro; IPR038257; CRISPR-assoc_Cas3_HD_sf.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR006474; Helicase_Cas3_CRISPR-ass_core.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01587; cas3_core; 1.
DR NCBIfam; TIGR01596; cas3_HD; 1.
DR Pfam; PF18019; Cas3_HD; 1.
DR Pfam; PF00270; DEAD; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51643; HD_CAS3; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW Antiviral defense {ECO:0000256|ARBA:ARBA00023118};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Endonuclease {ECO:0000313|EMBL:EKY02928.1};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000010457}.
FT DOMAIN 13..235
FT /note="HD Cas3-type"
FT /evidence="ECO:0000259|PROSITE:PS51643"
FT DOMAIN 502..667
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
SQ SEQUENCE 827 AA; 92676 MW; 43B9934E160DB08F CRC64;
MSDNQFIAHV RKADGEQQLL ETHLAETAEI AGLLAAKLGL GMAGKLLGLM HDFGKYSEKF
QSYIRHATGL LDPDADEEEN TPTDSKVDHS TAGAQWVYGR LKVFWAQYGI GELFGQMLGL
CIASHHGAGL IDCLDPDNGE AVWRKRFNKD DALTHLAQCE QVADKSVLQQ AQSLAGEALL
KEMLTALDAI IRPMSESFNK ERKHGEIRTP HKIEEFYLGC FTRFLFSCLI DADRINSADF
EREAQKDVRR FAEMPDWQAA IDKLEAHLAQ FPVRYPIDKI RRDISDTCLR RSGDLQGIYT
LTVPTGGGKT LASLRYALHH AQKHRLDRII YIIPYTSIID QNARAVRDIL GADWVLEHHS
NLEPEQQSWQ DKLLSENWDK PIVFTTMVQF LDAWFGGGTR GVRHVHAMTR SVLVFDEIQT
LPVKCVRLFC NVLNWLAQYG CSSAGLCTAT QPLLGQVPNP ELGSLKLAKD AEIMGGGQDL
DILFAGLSRV EIIPKLKAGG WSVDEAGAFL LERFQTASSC LFVVNTKRWA QELYQYCRRQ
NVPSDALFHL STNQCAAHRR AIFDVIKQRL QDGKPVLCIS TQLIEAGVDI SMACVIRALG
GLDSIAQAAG RCNRNGENTD KGQVYVLNLQ EPDFSKVLPD ITAGQANADR VFREFDGQDI
LQPDAMNRYF EYYFHQRGSE MSYTLANSVS GCLLDWLSDN SRNPYMPKNN KRGKAIPLLM
QSFKSAGRAF AAIDAPTRAV IVPYGKGQEL IAELCGAWDA KEMRRTLAQA QRYSVNVFPN
VWERLQKAQA VRETLAGSGI YYLDERHYHE AYGLCVDEAG EMTFYDL
//
