ID   L1NIE2_9NEIS            Unreviewed;       247 AA.
AC   L1NIE2;
DT   06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT   06-MAR-2013, sequence version 1.
DT   03-MAY-2023, entry version 38.
DE   SubName: Full=Putative oxygen-insensitive NADPH nitroreductase {ECO:0000313|EMBL:EKY03035.1};
GN   ORFNames=HMPREF9120_02807 {ECO:0000313|EMBL:EKY03035.1};
OS   Neisseria sp. oral taxon 020 str. F0370.
OC   Bacteria; Pseudomonadota; Betaproteobacteria; Neisseriales; Neisseriaceae;
OC   Neisseria.
OX   NCBI_TaxID=1127694 {ECO:0000313|EMBL:EKY03035.1, ECO:0000313|Proteomes:UP000010457};
RN   [1] {ECO:0000313|EMBL:EKY03035.1, ECO:0000313|Proteomes:UP000010457}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=F0370 {ECO:0000313|EMBL:EKY03035.1,
RC   ECO:0000313|Proteomes:UP000010457};
RA   Weinstock G., Sodergren E., Lobos E.A., Fulton L., Fulton R., Courtney L.,
RA   Fronick C., O'Laughlin M., Godfrey J., Wilson R.M., Miner T., Farmer C.,
RA   Delehaunty K., Cordes M., Minx P., Tomlinson C., Chen J., Wollam A.,
RA   Pepin K.H., Bhonagiri V., Zhang X., Suruliraj S., Warren W., Mitreva M.,
RA   Mardis E.R., Wilson R.K.;
RL   Submitted (MAY-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the flavin oxidoreductase frp family.
CC       {ECO:0000256|ARBA:ARBA00008366, ECO:0000256|PIRNR:PIRNR005426}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EKY03035.1}.
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DR   EMBL; AMER01000215; EKY03035.1; -; Genomic_DNA.
DR   RefSeq; WP_009427606.1; NZ_KB291165.1.
DR   AlphaFoldDB; L1NIE2; -.
DR   STRING; 1127694.HMPREF9120_02807; -.
DR   PATRIC; fig|1127694.3.peg.2601; -.
DR   HOGENOM; CLU_070764_0_2_4; -.
DR   OrthoDB; 3181400at2; -.
DR   Proteomes; UP000010457; Unassembled WGS sequence.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-UniRule.
DR   CDD; cd02146; NfsA-like; 1.
DR   Gene3D; 3.40.109.10; NADH Oxidase; 1.
DR   InterPro; IPR016446; Flavin_OxRdtase_Frp.
DR   InterPro; IPR029479; Nitroreductase.
DR   InterPro; IPR000415; Nitroreductase-like.
DR   PANTHER; PTHR43425; OXYGEN-INSENSITIVE NADPH NITROREDUCTASE; 1.
DR   PANTHER; PTHR43425:SF2; OXYGEN-INSENSITIVE NADPH NITROREDUCTASE; 1.
DR   Pfam; PF00881; Nitroreductase; 2.
DR   PIRSF; PIRSF005426; Frp; 1.
DR   SUPFAM; SSF55469; FMN-dependent nitroreductase-like; 1.
PE   3: Inferred from homology;
KW   Flavoprotein {ECO:0000256|PIRNR:PIRNR005426};
KW   FMN {ECO:0000256|PIRNR:PIRNR005426}; NADP {ECO:0000256|PIRNR:PIRNR005426};
KW   Oxidoreductase {ECO:0000256|PIRNR:PIRNR005426};
KW   Reference proteome {ECO:0000313|Proteomes:UP000010457}.
FT   DOMAIN          14..70
FT                   /note="Nitroreductase"
FT                   /evidence="ECO:0000259|Pfam:PF00881"
FT   DOMAIN          113..168
FT                   /note="Nitroreductase"
FT                   /evidence="ECO:0000259|Pfam:PF00881"
SQ   SEQUENCE   247 AA;  27109 MW;  BF15ECEE8665647F CRC64;
     MTLNSLPALD TALSHRSIRR FTEEPVSAEM LAAVLEAGRA APTSSYQQNN SVIRVSDREI
     RKGLREICAS EGGMGHAYVE HCAEFLVFCI DAARHHTVDA QVQTDWTEVL LTGAIDAGIM
     AQNVVLAAES LGLGAVYIGS IRNDIARVGE LLGLLEHTVP LFGLCLGHPD QQPLQRPRLP
     LDTLVSENRY RPASAEVLAA YNEEVKTYYR ERSGRDLDWA GQIANTLARP VRPFVLGYLQ
     GQGFAKR
//