ID L1QP82_9CLOT Unreviewed; 1205 AA.
AC L1QP82;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE SubName: Full=Peptidase, S8/S53 family {ECO:0000313|EMBL:EKY29794.1};
GN ORFNames=HMPREF0216_00038 {ECO:0000313|EMBL:EKY29794.1};
OS Clostridium celatum DSM 1785.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=545697 {ECO:0000313|EMBL:EKY29794.1, ECO:0000313|Proteomes:UP000010420};
RN [1] {ECO:0000313|EMBL:EKY29794.1, ECO:0000313|Proteomes:UP000010420}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 1785 {ECO:0000313|EMBL:EKY29794.1,
RC ECO:0000313|Proteomes:UP000010420};
RA Weinstock G., Sodergren E., Lobos E.A., Fulton L., Fulton R., Courtney L.,
RA Fronick C., O'Laughlin M., Godfrey J., Wilson R.M., Miner T., Farmer C.,
RA Delehaunty K., Cordes M., Minx P., Tomlinson C., Chen J., Wollam A.,
RA Pepin K.H., Bhonagiri V., Zhang X., Suruliraj S., Warren W., Mitreva M.,
RA Mardis E.R., Wilson R.K.;
RL Submitted (MAY-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the peptidase S8 family. {ECO:0000256|PROSITE-
CC ProRule:PRU01240, ECO:0000256|RuleBase:RU003355}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EKY29794.1}.
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DR EMBL; AMEZ01000002; EKY29794.1; -; Genomic_DNA.
DR AlphaFoldDB; L1QP82; -.
DR STRING; 545697.HMPREF0216_00038; -.
DR PATRIC; fig|545697.3.peg.39; -.
DR eggNOG; COG1404; Bacteria.
DR HOGENOM; CLU_280707_0_0_9; -.
DR Proteomes; UP000010420; Unassembled WGS sequence.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd07478; Peptidases_S8_CspA-like; 2.
DR Gene3D; 2.60.120.1290; -; 2.
DR Gene3D; 3.30.70.2980; -; 1.
DR Gene3D; 3.40.50.200; Peptidase S8/S53 domain; 2.
DR InterPro; IPR041365; CspB_prodomain.
DR InterPro; IPR034045; Pep_S8_CspA-like.
DR InterPro; IPR000209; Peptidase_S8/S53_dom.
DR InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR InterPro; IPR023827; Peptidase_S8_Asp-AS.
DR InterPro; IPR022398; Peptidase_S8_His-AS.
DR InterPro; IPR023828; Peptidase_S8_Ser-AS.
DR InterPro; IPR015500; Peptidase_S8_subtilisin-rel.
DR PANTHER; PTHR43399; SUBTILISIN-RELATED; 1.
DR PANTHER; PTHR43399:SF4; TK-SUBTILISIN; 1.
DR Pfam; PF18425; CspB_prodomain; 1.
DR Pfam; PF00082; Peptidase_S8; 4.
DR PRINTS; PR00723; SUBTILISIN.
DR SUPFAM; SSF52743; Subtilisin-like; 2.
DR PROSITE; PS51892; SUBTILASE; 2.
DR PROSITE; PS00136; SUBTILASE_ASP; 2.
DR PROSITE; PS00137; SUBTILASE_HIS; 1.
DR PROSITE; PS00138; SUBTILASE_SER; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU01240};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Reference proteome {ECO:0000313|Proteomes:UP000010420};
KW Serine protease {ECO:0000256|ARBA:ARBA00022825, ECO:0000256|PROSITE-
KW ProRule:PRU01240}.
FT DOMAIN 29..116
FT /note="Csp protease B prodomain"
FT /evidence="ECO:0000259|Pfam:PF18425"
FT DOMAIN 141..339
FT /note="Peptidase S8/S53"
FT /evidence="ECO:0000259|Pfam:PF00082"
FT DOMAIN 450..555
FT /note="Peptidase S8/S53"
FT /evidence="ECO:0000259|Pfam:PF00082"
FT DOMAIN 708..905
FT /note="Peptidase S8/S53"
FT /evidence="ECO:0000259|Pfam:PF00082"
FT DOMAIN 1047..1167
FT /note="Peptidase S8/S53"
FT /evidence="ECO:0000259|Pfam:PF00082"
FT ACT_SITE 150
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 208
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 516
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 717
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 789
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 1112
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
SQ SEQUENCE 1205 AA; 131672 MW; 54BF9900FC15D032 CRC64;
MISSNIKSYT YIDNRNYHEV INIENNKVGL GLLKNIPKSI LAKFSISNNF LASNSDTEIE
VSIISGSSPI EISQLVDSLG GKYTDLGYGY GIVLIPVENI VNLATSPQIQ YIELPKSLYT
NDYESNRASC ITQINSGELK GKGVLVGFID TGIDYTHPAF RNADGTTRIE YIYDLDEGGK
VYNKSQINEA LKSSNPYSIV DSTDVTGHGT HVAGIACAGG NIDSKYYGVA PESSIAMVKV
ARSRFALSTQ IMKGIKFLID KGKELNMPLA INMSLSTNDG AHNGSSLLEQ YISTVSATER
VSIVIAAGNE GEAAHHVGGT LEGINEVYFN ISSDESIVVI NLYKSILPEV SIELLCPCGF
STGEIILQQG FNEGTIGNTR YSIYLTGPKP FDVSGEIGIV LTGVNEFVSS GQWKITLKKL
NEYDGNFDMW LPISEGLNIN TKFLNPVVYN TIGIPATVRN IISVGSYNYL VNIISPFSGR
GEIYNGQYIK PDIVAPGEGI YSTIPNRGFD KKTGTSMAAP QVTGASALMM QWGIVKGNDP
YLYGERLKYF LIIGAKKGRR DIQYPDPAWG YGELCLRNSI NLVSQTLGLG FRNFYIKDRQ
ESKNVSEVSG IGVDYTTDSK DKIFILVEVP GEEALENILK IPGVAGVMIS TNFAIIIAPA
NIINEITKFV VRVVNIEVST ILTLNELSPV EASGAPTFNN NPYLRLNGKD VLVAVIDTGI
DYLNKEFQKE DDTTRILRIW DQTIQGDKEV NGLKYGIEYT EEQINQAINL QTSGGDPYSI
VQSKDDIGHG TKLSGIIGGR GINPELKGAA PDCQFIIVKL ARATKVELDL ALIDKTDVPS
YSPWSVLLGL RYAISTARML KKPVVVFIPL GSSMGSHTGN GIIESSIENF SSQAGTVIIV
PVGNEGNTDT HTEGKIEKVG DIEEIEIRVG EKQKNLPIEI WIGKPDRVKL SIISPAGEVI
DNLESKNTNN ERIKFLYEGT EMIVNFTSPE LTTGDSLIFI RAYKLRAGIW KFRLTGQYIV
EGKYSAWIPQ RELLDDETKF LNPVEYTTLT LPSTSRGAIS VAYYNQDNNA VVSESGRGYT
RNGEIKPDIA AGGVKALVTN PGGNTSLMSG SSVAGAVVAG CCALILQWAV SDGNYPDIYS
SQIKSYIISG AKGRPGDVYP NRDWGYGMFD LQGIFDRIRE TYSPRSDEYE EYKVNNLFIR
KPKDL
//
