GenomeNet

Database: UniProt
Entry: L2F7R4_9GAMM
LinkDB: L2F7R4_9GAMM
Original site: L2F7R4_9GAMM 
ID   L2F7R4_9GAMM            Unreviewed;       242 AA.
AC   L2F7R4;
DT   06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT   06-MAR-2013, sequence version 1.
DT   24-JAN-2024, entry version 53.
DE   RecName: Full=Ubiquinone biosynthesis O-methyltransferase {ECO:0000256|HAMAP-Rule:MF_00472};
DE   AltName: Full=2-polyprenyl-6-hydroxyphenol methylase {ECO:0000256|HAMAP-Rule:MF_00472};
DE            EC=2.1.1.222 {ECO:0000256|HAMAP-Rule:MF_00472};
DE   AltName: Full=3-demethylubiquinone 3-O-methyltransferase {ECO:0000256|HAMAP-Rule:MF_00472};
DE            EC=2.1.1.64 {ECO:0000256|HAMAP-Rule:MF_00472};
GN   Name=ubiG {ECO:0000256|HAMAP-Rule:MF_00472};
GN   ORFNames=MOMA_01740 {ECO:0000313|EMBL:ELA09089.1};
OS   Moraxella macacae 0408225.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Moraxellales; Moraxellaceae;
OC   Moraxella.
OX   NCBI_TaxID=1230338 {ECO:0000313|EMBL:ELA09089.1, ECO:0000313|Proteomes:UP000023795};
RN   [1] {ECO:0000313|EMBL:ELA09089.1, ECO:0000313|Proteomes:UP000023795}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=0408225 {ECO:0000313|EMBL:ELA09089.1,
RC   ECO:0000313|Proteomes:UP000023795};
RX   PubMed=23409273;
RA   Ladner J.T., Whitehouse C.A., Koroleva G.I., Palacios G.F.;
RT   "Genome Sequence of Moraxella macacae 0408225, a Novel Bacterial Species
RT   Isolated from a Cynomolgus Macaque with Epistaxis.";
RL   Genome Announc. 1:E00188-12(2013).
CC   -!- FUNCTION: O-methyltransferase that catalyzes the 2 O-methylation steps
CC       in the ubiquinone biosynthetic pathway. {ECO:0000256|HAMAP-
CC       Rule:MF_00472}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 3-(all-trans-polyprenyl)benzene-1,2-diol + S-adenosyl-L-
CC         methionine = a 2-methoxy-6-(all-trans-polyprenyl)phenol + H(+) + S-
CC         adenosyl-L-homocysteine; Xref=Rhea:RHEA:31411, Rhea:RHEA-COMP:9550,
CC         Rhea:RHEA-COMP:9551, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856,
CC         ChEBI:CHEBI:59789, ChEBI:CHEBI:62729, ChEBI:CHEBI:62731;
CC         EC=2.1.1.222; Evidence={ECO:0000256|HAMAP-Rule:MF_00472};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 3-demethylubiquinol + S-adenosyl-L-methionine = a ubiquinol
CC         + H(+) + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:44380, Rhea:RHEA-
CC         COMP:9566, Rhea:RHEA-COMP:10914, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:17976, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC         ChEBI:CHEBI:84422; EC=2.1.1.64; Evidence={ECO:0000256|HAMAP-
CC         Rule:MF_00472};
CC   -!- PATHWAY: Cofactor biosynthesis; ubiquinone biosynthesis.
CC       {ECO:0000256|HAMAP-Rule:MF_00472}.
CC   -!- SIMILARITY: Belongs to the methyltransferase superfamily. UbiG/COQ3
CC       family. {ECO:0000256|HAMAP-Rule:MF_00472}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:ELA09089.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; ANIN01000001; ELA09089.1; -; Genomic_DNA.
DR   RefSeq; WP_009766909.1; NZ_ANIN01000001.1.
DR   AlphaFoldDB; L2F7R4; -.
DR   STRING; 1230338.MOMA_01740; -.
DR   PATRIC; fig|1230338.3.peg.384; -.
DR   eggNOG; COG2227; Bacteria.
DR   OrthoDB; 9801538at2; -.
DR   UniPathway; UPA00232; -.
DR   Proteomes; UP000023795; Unassembled WGS sequence.
DR   GO; GO:0102208; F:2-polyprenyl-6-hydroxyphenol methylase activity; IEA:RHEA.
DR   GO; GO:0008425; F:2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity; IEA:InterPro.
DR   GO; GO:0008689; F:3-demethylubiquinone-9 3-O-methyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   GO; GO:0006744; P:ubiquinone biosynthetic process; IEA:UniProtKB-UniRule.
DR   CDD; cd02440; AdoMet_MTases; 1.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR   HAMAP; MF_00472; UbiG; 1.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   InterPro; IPR010233; UbiG_MeTrfase.
DR   NCBIfam; TIGR01983; UbiG; 1.
DR   PANTHER; PTHR43464; METHYLTRANSFERASE; 1.
DR   PANTHER; PTHR43464:SF19; UBIQUINONE BIOSYNTHESIS O-METHYLTRANSFERASE, MITOCHONDRIAL; 1.
DR   Pfam; PF13489; Methyltransf_23; 1.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE   3: Inferred from homology;
KW   Methyltransferase {ECO:0000256|HAMAP-Rule:MF_00472,
KW   ECO:0000313|EMBL:ELA09089.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000023795};
KW   S-adenosyl-L-methionine {ECO:0000256|HAMAP-Rule:MF_00472};
KW   Transferase {ECO:0000256|HAMAP-Rule:MF_00472, ECO:0000313|EMBL:ELA09089.1};
KW   Ubiquinone {ECO:0000313|EMBL:ELA09089.1};
KW   Ubiquinone biosynthesis {ECO:0000256|ARBA:ARBA00022688, ECO:0000256|HAMAP-
KW   Rule:MF_00472}.
FT   BINDING         40
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_00472"
FT   BINDING         65
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_00472"
FT   BINDING         86
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_00472"
FT   BINDING         130
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_00472"
SQ   SEQUENCE   242 AA;  27348 MW;  78B62266D4C49C8A CRC64;
     MTQTHNNADF HEIGKFTALA NEWWDKNGAF ATLHDINPLR LNWVEEQTKL QHNSDLSAKK
     VLDVGCGGGI LSHAMAERGA QVMGIDLGEE NIQAARFHAK KTHQVIDFQC TAVEDLAKTH
     AAQFDVVTCM EMLEHVPNPK SIIDACFALL KPGGVLIMST INRNFKSYLF AIIGAEYVLR
     LLDKGTHDFN KFITPAELDR FAERSGFKRQ DLIGLHYNPL TKRYWLAQNV DVNYMMAVYK
     PK
//
DBGET integrated database retrieval system