ID L2FEN6_COLFN Unreviewed; 1294 AA.
AC L2FEN6;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 24-JAN-2024, entry version 52.
DE RecName: Full=DNA mismatch repair protein {ECO:0000256|PIRNR:PIRNR037677};
GN ORFNames=CGGC5_2008 {ECO:0000313|EMBL:ELA24817.1};
OS Colletotrichum fructicola (strain Nara gc5) (Anthracnose fungus)
OS (Colletotrichum gloeosporioides (strain Nara gc5)).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Glomerellales; Glomerellaceae; Colletotrichum;
OC Colletotrichum gloeosporioides species complex.
OX NCBI_TaxID=1213859 {ECO:0000313|EMBL:ELA24817.1};
RN [1] {ECO:0000313|EMBL:ELA24817.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Nara gc5 {ECO:0000313|EMBL:ELA24817.1};
RA Gan P.H.P., Ikeda K., Irieda H., Narusaka M., O'Connell R.J., Narusaka Y.,
RA Takano Y., Kubo Y., Shirasu K.;
RT "Genome analysis of Colletotrichum orbiculare and Colletotrichum
RT fructicola.";
RL Submitted (AUG-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the post-replicative DNA mismatch repair system
CC (MMR). {ECO:0000256|PIRNR:PIRNR037677, ECO:0000256|RuleBase:RU003756}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|PIRNR:PIRNR037677, ECO:0000256|RuleBase:RU003756}.
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DR EMBL; KB021236; ELA24817.1; -; Genomic_DNA.
DR RefSeq; XP_007286129.1; XM_007286067.1.
DR STRING; 1213859.L2FEN6; -.
DR EnsemblFungi; ELA24817; ELA24817; CGGC5_2008.
DR HOGENOM; CLU_002472_1_0_1; -.
DR OrthoDB; 168255at2759; -.
DR GO; GO:0032301; C:MutSalpha complex; IEA:EnsemblFungi.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:EnsemblFungi.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0000400; F:four-way junction DNA binding; IEA:EnsemblFungi.
DR GO; GO:0032137; F:guanine/thymine mispair binding; IEA:EnsemblFungi.
DR GO; GO:0032138; F:single base insertion or deletion binding; IEA:EnsemblFungi.
DR GO; GO:0036297; P:interstrand cross-link repair; IEA:EnsemblFungi.
DR GO; GO:0043570; P:maintenance of DNA repeat elements; IEA:EnsemblFungi.
DR GO; GO:0000710; P:meiotic mismatch repair; IEA:EnsemblFungi.
DR GO; GO:0043111; P:replication fork arrest; IEA:EnsemblFungi.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11361:SF148; DNA MISMATCH REPAIR PROTEIN MSH6; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PIRNR:PIRNR037677};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|PIRNR:PIRNR037677};
KW DNA repair {ECO:0000256|PIRNR:PIRNR037677, ECO:0000256|RuleBase:RU003756};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PIRNR:PIRNR037677};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|PIRNR:PIRNR037677}.
FT DOMAIN 1132..1148
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT REGION 17..37
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 68..375
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 868..895
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 939..966
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 76..118
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 134..148
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 159..213
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 229..251
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 252..277
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 325..347
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 357..371
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1294 AA; 144131 MW; 84E309CBB7C5F49B CRC64;
MLSECLLLAP AWNVRSSLPP GPSIKHSSEP DAARTRLRDS TIFPDAIPST AGAQHLLQSQ
KDYLRSTHNH TFTDPTRRHG AQIITSGSPA KTPSLKRQPS SSSGTQKTIV QFFSKSASKP
TPKPAAKGPD SSPCLRESTR TNELPKVKQP PSMTPVPSCD AMEPSSSQEN MDGTGLKVAQ
DSLPSPSTPA ETVTPQVSRS RPVLPSSSPT RKGRKAVNYA EPSDDEDDDP FDRIRAAGTR
RRTKTPAVPA DDGDDYEDAA SNDGPDEDEE MDDFVVSDES DAPSRSKKRK RPETTKKTQS
RKKTTVSSPI KEEETADEDE MMEELPSTST AQQWRYDPNS VASSAPRSAQ GPAVRRPAAS
KRKEKAHATE PEARYPWLAN IQDINKNSPG DPEYDPSSVY IPPGAWNKFS PFEKQYWEIK
QKLWDTVVFF KKGKFYELYE NDATIGHQLF DLKLTDRVNM RMVGVPESSL DMWVNQFVAK
GYKVARVDQM ESALGKEMRE RGDTSAKAKK ADKIIRRELA CVLTGGTLVD GSMLQDDLAT
FCACIKESVI DGSPAFGITF VDCATGQFFI SEFEDDADLT KFETFVAQTS PRELILEKSR
ISTKALRILK NNTSPMTIWN YLKPATEFLD ADMSRREISS GGYFANEDGE ETWPDALAQA
KDKDLLMSSL GGLIHYLKFL KIEGSLLSQG NFEWYTPIRR NGTLILDGQT LINLEIFANT
VNGGPEGTLF TLLNRCVTPF GKRLFRQWVC HPLCDIKRIN ERLDAVDMLN SDRSVREQFS
SQMTKMPDLE RLISRIHATL CKPEDFVRVL EGFEQIEYTM GLLGAFGGGN GLIDRLLASM
PNLNEPLSYW KTAFDRKKAR DEKLLIPERG IEEDFDNSQD RIEEIKEELQ SLLGRKKSEL
KCKTIKFTDI GKEIYQIEAP KAVKVPNNWR QMSATASVKR YYFEELTDLV RELQEAEETH
SQIVKEVATR FFQRFDADYD TWSQSIRIIS QLDCLVSLSK ASSSLGEPSC RPEFVDEDRS
VVEFEELRHP CMLNTVSDFI PNDVKLGGDS AKINLLTGAN AAGKSTVLRM SCVAVIMAQI
GCYVPAVSAR LTPVDRIMSR LGANDNIFAS QSTFFVELSE TKKILSEATP RSLVILDELG
RGTSSYDGVA VAQAVLHHVA THVGCVGFFA THYHSLATEF ENHPEIVPRR MQIHVDEEER
RVTFLYKLEE GVAEGSFGMH CAAMCGISNR VIERAEVAAK EWEHTSRLKE SLEKAKSGCY
IPLGVLSDVA SLLNGGDEVG KRGVEVLLRA VEAL
//
