ID L2FTX0_COLFN Unreviewed; 831 AA.
AC L2FTX0;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE RecName: Full=ribonuclease Z {ECO:0000256|ARBA:ARBA00012477};
DE EC=3.1.26.11 {ECO:0000256|ARBA:ARBA00012477};
GN Name=trz1 {ECO:0000313|EMBL:KAF4484730.1};
GN ORFNames=CGGC5_10335 {ECO:0000313|EMBL:ELA29178.1}, CGGC5_v007420
GN {ECO:0000313|EMBL:KAF4484730.1};
OS Colletotrichum fructicola (strain Nara gc5) (Anthracnose fungus)
OS (Colletotrichum gloeosporioides (strain Nara gc5)).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Glomerellales; Glomerellaceae; Colletotrichum;
OC Colletotrichum gloeosporioides species complex.
OX NCBI_TaxID=1213859 {ECO:0000313|EMBL:ELA29178.1};
RN [1] {ECO:0000313|EMBL:ELA29178.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Nara gc5 {ECO:0000313|EMBL:ELA29178.1};
RA Gan P.H.P., Ikeda K., Irieda H., Narusaka M., O'Connell R.J., Narusaka Y.,
RA Takano Y., Kubo Y., Shirasu K.;
RT "Genome analysis of Colletotrichum orbiculare and Colletotrichum
RT fructicola.";
RL Submitted (AUG-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:KAF4484730.1, ECO:0000313|Proteomes:UP000011096}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nara gc5 {ECO:0000313|EMBL:KAF4484730.1,
RC ECO:0000313|Proteomes:UP000011096};
RA Gan P.H.P., Ikeda K., Irieda H., Narusaka M., O'Connell R.J., Narusaka Y.,
RA Takano Y., Kubo Y., Shirasu K.;
RL Submitted (AUG-2012) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:KAF4484730.1, ECO:0000313|Proteomes:UP000011096}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nara gc5 {ECO:0000313|EMBL:KAF4484730.1,
RC ECO:0000313|Proteomes:UP000011096};
RA Gan P., Shirasu K.;
RT "Genome sequencing and assembly of multiple isolates from the
RT Colletotrichum gloeosporioides species complex.";
RL Submitted (APR-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Endonucleolytic cleavage of RNA, removing extra 3' nucleotides
CC from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy
CC group is left at the tRNA terminus and a 5'-phosphoryl group is left
CC at the trailer molecule.; EC=3.1.26.11;
CC Evidence={ECO:0000256|ARBA:ARBA00000402};
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000256|ARBA:ARBA00004173}.
CC -!- SIMILARITY: Belongs to the RNase Z family.
CC {ECO:0000256|ARBA:ARBA00007823}.
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DR EMBL; KB020870; ELA29178.1; -; Genomic_DNA.
DR EMBL; ANPB02000004; KAF4484730.1; -; Genomic_DNA.
DR RefSeq; XP_007281742.1; XM_007281680.1.
DR AlphaFoldDB; L2FTX0; -.
DR STRING; 1213859.L2FTX0; -.
DR EnsemblFungi; ELA29178; ELA29178; CGGC5_10335.
DR HOGENOM; CLU_006220_0_0_1; -.
DR InParanoid; L2FTX0; -.
DR OrthoDB; 296811at2759; -.
DR Proteomes; UP000011096; Unassembled WGS sequence.
DR GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR GO; GO:0042781; F:3'-tRNA processing endoribonuclease activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd07718; RNaseZ_ELAC1_ELAC2-C-term-like_MBL-fold; 1.
DR Gene3D; 3.60.15.10; Ribonuclease Z/Hydroxyacylglutathione hydrolase-like; 3.
DR InterPro; IPR001279; Metallo-B-lactamas.
DR InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR InterPro; IPR047151; RNZ2-like.
DR InterPro; IPR027794; tRNase_Z_dom.
DR PANTHER; PTHR12553; ZINC PHOSPHODIESTERASE ELAC PROTEIN 2; 1.
DR PANTHER; PTHR12553:SF49; ZINC PHOSPHODIESTERASE ELAC PROTEIN 2; 1.
DR Pfam; PF12706; Lactamase_B_2; 1.
DR Pfam; PF13691; Lactamase_B_4; 1.
DR SUPFAM; SSF56281; Metallo-hydrolase/oxidoreductase; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000011096};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 6..67
FT /note="tRNase Z endonuclease"
FT /evidence="ECO:0000259|Pfam:PF13691"
FT DOMAIN 567..774
FT /note="Metallo-beta-lactamase"
FT /evidence="ECO:0000259|Pfam:PF12706"
SQ SEQUENCE 831 AA; 92979 MW; 3FD436E1014EA21F CRC64;
MTNHVQITTT PTADTGGSLL LHFDHRRYLF GHLSEGTQRA LGQRKVALAK LENMFMSGQT
KWEYTGGMIG MMLTVADVLE GSRREIEAQN QARKQSQKAL LETKGPERIE IHGGRNLTHS
LATARYFVFR KGMPIHSVEC HDDPRIANPE ATTPDWEDDA IQVWKVPVVA GEPQARSRKR
SHEVMAAEDE QVAADHTAQP TLTPQEHERL NREGVAAVVE DMFNSDWSKD TLCETKLHKV
SLPATIFVRK NGQIERYKGP LPGDKGPVPD IDVLVRFPWP ATKVVRLPDP KLPSDMSVCY
IVKNRGRRGK FNPQLAKQYG IKPFEFKHLA AGKTVKGADG VDVTPDMVLG ERIKPCGFAL
VDIPNLSAVE SFLARPEWKN SSLMEDVPIF YWLLGPTVID DTRIQNFMRE RTDVNHIVLA
PQTSPNMVTI ESCAILLAKL RRIDPDRFPL LNFDNSVRDL SFIGPNVQAG RVGMKTMLSP
SFSMKDDEIL PFPTFEEAGA IPEEVLALAD EAKAAIKEPK FIAEVEQVEK DIPNRDAEII
PLGTGSALPS KYRNVSSTLI RVPQYGNYIL DAGENTMGQL RRAFLADELV QILRDLRCIF
ISHMHADHHL GTASLLRAWC DATEHLSPQP RLVIYCPVSM RLFLQEYGRI ENIQTVNGRR
IETRNVVWPK DDAKLPKDDS TRLASAVLVP VKHCQNSYAP VFSFPSGLKI AFSGDCRPSD
SLVKAGKGAT LLIHESTFDD NKKGDAIAKK HSTMSEALDV AYRMGARRVL LTHFSQRYAK
VPITEKRETA DGSDQAVLLA FDQMRVKLGE FRQAQKFLPA IRLYFELTGA D
//
