ID L2FUH4_COLFN Unreviewed; 1237 AA.
AC L2FUH4;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 28-JUN-2023, entry version 41.
DE RecName: Full=MMS19 nucleotide excision repair protein {ECO:0000256|RuleBase:RU367072};
GN ORFNames=CGGC5_10237 {ECO:0000313|EMBL:ELA29348.1}, CGGC5_v013648
GN {ECO:0000313|EMBL:KAF4477285.1};
OS Colletotrichum fructicola (strain Nara gc5) (Anthracnose fungus)
OS (Colletotrichum gloeosporioides (strain Nara gc5)).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Glomerellales; Glomerellaceae; Colletotrichum;
OC Colletotrichum gloeosporioides species complex.
OX NCBI_TaxID=1213859 {ECO:0000313|EMBL:ELA29348.1};
RN [1] {ECO:0000313|EMBL:ELA29348.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Nara gc5 {ECO:0000313|EMBL:ELA29348.1};
RA Gan P.H.P., Ikeda K., Irieda H., Narusaka M., O'Connell R.J., Narusaka Y.,
RA Takano Y., Kubo Y., Shirasu K.;
RT "Genome analysis of Colletotrichum orbiculare and Colletotrichum
RT fructicola.";
RL Submitted (AUG-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:KAF4477285.1, ECO:0000313|Proteomes:UP000011096}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nara gc5 {ECO:0000313|EMBL:KAF4477285.1,
RC ECO:0000313|Proteomes:UP000011096};
RA Gan P.H.P., Ikeda K., Irieda H., Narusaka M., O'Connell R.J., Narusaka Y.,
RA Takano Y., Kubo Y., Shirasu K.;
RL Submitted (AUG-2012) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:KAF4477285.1, ECO:0000313|Proteomes:UP000011096}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nara gc5 {ECO:0000313|EMBL:KAF4477285.1,
RC ECO:0000313|Proteomes:UP000011096};
RA Gan P., Shirasu K.;
RT "Genome sequencing and assembly of multiple isolates from the
RT Colletotrichum gloeosporioides species complex.";
RL Submitted (APR-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Key component of the cytosolic iron-sulfur protein assembly
CC (CIA) complex, a multiprotein complex that mediates the incorporation
CC of iron-sulfur cluster into apoproteins specifically involved in DNA
CC metabolism and genomic integrity. In the CIA complex, MMS19 acts as an
CC adapter between early-acting CIA components and a subset of cellular
CC target iron-sulfur proteins. {ECO:0000256|RuleBase:RU367072}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU367072}.
CC -!- SIMILARITY: Belongs to the MET18/MMS19 family.
CC {ECO:0000256|RuleBase:RU367072}.
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DR EMBL; KB020864; ELA29348.1; -; Genomic_DNA.
DR EMBL; ANPB02000008; KAF4477285.1; -; Genomic_DNA.
DR RefSeq; XP_007281617.1; XM_007281555.1.
DR AlphaFoldDB; L2FUH4; -.
DR STRING; 1213859.L2FUH4; -.
DR EnsemblFungi; ELA29348; ELA29348; CGGC5_10237.
DR HOGENOM; CLU_007956_0_0_1; -.
DR InParanoid; L2FUH4; -.
DR OrthoDB; 38995at2759; -.
DR Proteomes; UP000011096; Unassembled WGS sequence.
DR GO; GO:0097361; C:CIA complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR GO; GO:0016226; P:iron-sulfur cluster assembly; IEA:UniProtKB-UniRule.
DR GO; GO:0097428; P:protein maturation by iron-sulfur cluster transfer; IEA:UniProtKB-UniRule.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR039920; MET18/MMS19.
DR InterPro; IPR024687; MMS19_C.
DR InterPro; IPR029240; MMS19_N.
DR PANTHER; PTHR12891; DNA REPAIR/TRANSCRIPTION PROTEIN MET18/MMS19; 1.
DR PANTHER; PTHR12891:SF0; MMS19 NUCLEOTIDE EXCISION REPAIR PROTEIN HOMOLOG; 1.
DR Pfam; PF12460; MMS19_C; 1.
DR Pfam; PF14500; MMS19_N; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|RuleBase:RU367072};
KW DNA repair {ECO:0000256|RuleBase:RU367072};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU367072};
KW Reference proteome {ECO:0000313|Proteomes:UP000011096};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 70..327
FT /note="MMS19 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF14500"
FT DOMAIN 730..1153
FT /note="MMS19 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF12460"
SQ SEQUENCE 1237 AA; 136922 MW; 987ADC6F57F99F1C CRC64;
MADFRKLALE YVLSDDLERH ASITKEASSA IQSAPRPSNP VARWVESIRP WMPNANADQM
EDSEDGESSG DIIARSKALG FLAGTLEHLD PGFLKADQVN LLVAFFGSMF KVDHKAGIMP
AAKALDRTIS MKAFQPSKGN DIIQSICSLG DDFKNQVAET RATVYELLDH LVTNPDVASE
LQYQHGATTG FITDLLQLCR NERDPKCLMI WFKILKTFLA DYSPAQELVD EIFGIFSAYF
PISLRASQHP SGITADDLKS ALRECFSAHH RVASKAIPYL IGRLDQGDSV TVDILKTLTA
CLVKYEHVQQ GITPFVEKIW GSLKYEVRNG EIEDTINATL EVIRTIAKRL SGDELRDFAL
TVQRDCLEDL ANPIYTAASG KLLISVHSAK PSAFALMIAP SITHVKDNLR HTKSPEHTKN
LLILLNSLLE LRQALIGGGA ELSVDDAAAF KATEPMLAPL YKQAYLPPFQ QAIQDGAQKE
ETAIGQQAIK GMGLMVCQRA AQTGLSTQPM LPEATLSEIC DDLASVILKA PERYATDELQ
ANIADEAVLA LQKATTAYPP ALEKLVEDSF RVCEPYIAFP ETSVTGLIGT LEQIIPKLAF
ISCSQVPSQE NKFGNYILLL GVLLKNLQSM LDIKAPPQVW SVFASGIQMT MRYYRDAIHA
LVPRSSALNF KDKRFHPETW VNYVAARYPQ LPRVDGESSD SAAAVDAMDV DSKEQPLENA
SDELHGDFTL ISLFVVRQLY RRATRIVSYA DDTELSLELS TDFVNKDPDA RNFEDCYLHY
ISTMASFVIR EMNELEQTAL LLNEEVITLF RGDDEYLHSD SNHAHPWANA QLRDAMLRTV
SPAKSYSMRD PPKFPISGFS QGRAVVLSLG IVQPLHPTAI QRLVERGTAH QILIAGLLSR
DHSASPRSRH IVAHILTILA NKCPVEKLSE IVAMIEKQMK FVVGDGSLSE ESENETGFLE
HEAKRIPGET PAQARANLAR PVYAITAGVL RRYTGNAFKQ VLSAIQLGPA NKETGHILAR
NFEIIFSPYG CLAKEYYGLA KPLWLQRAYF ELVKPMLAKA WPAGSNSSED MLVAANYSIA
VLAAVKHLPF NIYEDDTEDL VRLVLCAVRY LPSGGDVQAG LKVLEEIAQR SPERIKPFLK
SIIEACISIY TRGGSQSEDS AWMPAGYMPF DHSDISQAQC RYLVVRLLGL LPPQFEDRHL
LDSAAHVRRV LSQSSGDRVR EVRKAALVAR AAWAEVK
//
