ID L2FV75_COLFN Unreviewed; 1000 AA.
AC L2FV75;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 08-NOV-2023, entry version 51.
DE RecName: Full=Transcription elongation factor SPT5 {ECO:0000256|ARBA:ARBA00020181, ECO:0000256|PIRNR:PIRNR036945};
GN ORFNames=CGGC5_9953 {ECO:0000313|EMBL:ELA29633.1};
OS Colletotrichum fructicola (strain Nara gc5) (Anthracnose fungus)
OS (Colletotrichum gloeosporioides (strain Nara gc5)).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Glomerellales; Glomerellaceae; Colletotrichum;
OC Colletotrichum gloeosporioides species complex.
OX NCBI_TaxID=1213859 {ECO:0000313|EMBL:ELA29633.1};
RN [1] {ECO:0000313|EMBL:ELA29633.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Nara gc5 {ECO:0000313|EMBL:ELA29633.1};
RA Gan P.H.P., Ikeda K., Irieda H., Narusaka M., O'Connell R.J., Narusaka Y.,
RA Takano Y., Kubo Y., Shirasu K.;
RT "Genome analysis of Colletotrichum orbiculare and Colletotrichum
RT fructicola.";
RL Submitted (AUG-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: The SPT4-SPT5 complex mediates both activation and inhibition
CC of transcription elongation, and plays a role in pre-mRNA processing.
CC This complex seems to be important for the stability of the RNA
CC polymerase II elongation machinery on the chromatin template but not
CC for the inherent ability of this machinery to translocate down the
CC gene. {ECO:0000256|ARBA:ARBA00024691, ECO:0000256|PIRNR:PIRNR036945}.
CC -!- SUBUNIT: Component of the SPT4-SPT5 complex. Interacts with RNA
CC polymerase II. {ECO:0000256|ARBA:ARBA00025870}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PIRNR:PIRNR036945}.
CC -!- SIMILARITY: Belongs to the SPT5 family. {ECO:0000256|ARBA:ARBA00006956,
CC ECO:0000256|PIRNR:PIRNR036945}.
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DR EMBL; KB020844; ELA29633.1; -; Genomic_DNA.
DR RefSeq; XP_007281319.1; XM_007281257.1.
DR AlphaFoldDB; L2FV75; -.
DR STRING; 1213859.L2FV75; -.
DR EnsemblFungi; ELA29633; ELA29633; CGGC5_9953.
DR HOGENOM; CLU_003537_1_1_1; -.
DR OrthoDB; 24955at2759; -.
DR GO; GO:0032044; C:DSIF complex; IEA:EnsemblFungi.
DR GO; GO:0003711; F:transcription elongation factor activity; IEA:EnsemblFungi.
DR GO; GO:0032784; P:regulation of DNA-templated transcription elongation; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR GO; GO:0006368; P:transcription elongation by RNA polymerase II; IEA:EnsemblFungi.
DR CDD; cd06081; KOW_Spt5_1; 1.
DR CDD; cd06082; KOW_Spt5_2; 1.
DR CDD; cd06083; KOW_Spt5_3; 1.
DR CDD; cd06084; KOW_Spt5_4; 1.
DR CDD; cd06085; KOW_Spt5_5; 1.
DR CDD; cd09888; NGN_Euk; 1.
DR Gene3D; 2.30.30.30; -; 3.
DR Gene3D; 3.30.70.940; NusG, N-terminal domain; 1.
DR InterPro; IPR005824; KOW.
DR InterPro; IPR041973; KOW_Spt5_1.
DR InterPro; IPR041975; KOW_Spt5_2.
DR InterPro; IPR041976; KOW_Spt5_3.
DR InterPro; IPR041977; KOW_Spt5_4.
DR InterPro; IPR041978; KOW_Spt5_5.
DR InterPro; IPR005100; NGN-domain.
DR InterPro; IPR036735; NGN_dom_sf.
DR InterPro; IPR039385; NGN_Euk.
DR InterPro; IPR014722; Rib_uL2_dom2.
DR InterPro; IPR039659; SPT5.
DR InterPro; IPR024945; Spt5_C_dom.
DR InterPro; IPR022581; Spt5_N.
DR InterPro; IPR017071; TF_Spt5_eukaryote.
DR InterPro; IPR008991; Translation_prot_SH3-like_sf.
DR PANTHER; PTHR11125; SUPPRESSOR OF TY 5; 1.
DR PANTHER; PTHR11125:SF7; TRANSCRIPTION ELONGATION FACTOR SPT5; 1.
DR Pfam; PF03439; Spt5-NGN; 1.
DR Pfam; PF11942; Spt5_N; 1.
DR PIRSF; PIRSF036945; Spt5; 1.
DR SMART; SM01104; CTD; 1.
DR SMART; SM00739; KOW; 4.
DR SUPFAM; SSF50104; Translation proteins SH3-like domain; 1.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR036945};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|PIRNR:PIRNR036945}.
FT DOMAIN 309..337
FT /note="KOW"
FT /evidence="ECO:0000259|SMART:SM00739"
FT DOMAIN 469..496
FT /note="KOW"
FT /evidence="ECO:0000259|SMART:SM00739"
FT DOMAIN 522..550
FT /note="KOW"
FT /evidence="ECO:0000259|SMART:SM00739"
FT DOMAIN 733..760
FT /note="KOW"
FT /evidence="ECO:0000259|SMART:SM00739"
FT DOMAIN 816..951
FT /note="Spt5 C-terminal"
FT /evidence="ECO:0000259|SMART:SM01104"
FT REGION 1..175
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 703..731
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 777..1000
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 30..66
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 67..94
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 116..140
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 141..175
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 843..858
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 879..893
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1000 AA; 108531 MW; C819D828B8970447 CRC64;
MASNDHNRYD DSDDEDDFNP APADLSDDEP SHNSGQRHAG SDARESSPAA DDDDAAAAPK
SRRVDDDEDD EQDDEEGGQN DDDEEDDEDE EDEDDVQQGH RRKRRRDRRA VFFDIEAEVE
DEEDGEDEEK DGEEIEDFID NAHPDDIAES GGLDDDRRHR ELDRRREMES SMDAEKQAEI
LRQRYGNRRP NKGFGDSTVV PKRLLMPSVE DPTIWAVRCK EGKEREVVYS IMKRIDERMG
TKDELAIISA FERGGPTSVM KGYIYVEANR STDIMVALDG MFNVYPRSKM ILVDIKDMPD
LLRVTKTPTL EPGAWVRLRK PAKHAGDLAQ VIDVTENGLE ARVRFIPRLD YGMRDDALAA
LTSDGKRKRP VGVPGPRPPQ RLFNETEARK RHPRHIQGNP TTKVWTYMGD EFENGFQVKD
IKIQQLVVTD VNPTLEEVTR FASGAEDGTE NLDLKALAAS LKDSNINVTY LPGDVIEVYD
GEQKGVVGKA TNVQGDIVTM QVTEGDLVGQ VIEVPTKGLR KRFKIGDHVK VTSGSRFRDE
VGMVVKISED RVTFLTDQTN TEVTVFSKDL REASDIGGQG ALGQYELFDL VQLDPTTVGC
IVKVDRESVV VLDQNGDTRQ VMPSQIANKL PKRNADRNGS EIRLDDVVRE YGAQQRQGKI
IHIHRAYVFL HSNNNNENAG VFVTKASNVT TIAAKGGRVL SAGPNLDQMN PAMKRNPGGA
ESKMAPPKTF GRDRSINQTV IIRKGGYKGL LGIVKDATET HARVELHTKS KTITVPKDHL
SFKDKNTGAK IDINGRGPRP GQGGAPGGGR GGDWQGGRTP VASSGAERTP AWGSRTPAPT
GGRTPAWKSS SQDYGSGSRT PAWADGSRTA YGDGSAPTPG ASGSDSWGYT PGNSGYDAPT
PGGNLLGAPT PGALNAPTPG AYSAPTPAAA SAPTPGGGWQ GGWAADSAPT PAAGAPTPAA
SGFASSSAPP PLLPMARPRH RRPAGLDTPT ITDQTASQDV
//
